Agenus (AGEN) Operating Margin (2010 - 2026)
Agenus (AGEN) recorded Operating Margin of 32.72% in Q2 2026, up 97.76 percentage points from -65.05% a year earlier but down 11.91 percentage points from the prior quarter.
Powered by 
Analysis
Agenus (AGEN) Operating Margin (2010 - 2026) Analysis & Trends
On a TTM basis, Agenus' Operating Margin came in at 27.28% as of Jun 30, 2026, up 113.24 percentage points year-over-year; for FY2025, it was -17.66%, up 98.78 percentage points from FY2024.
- Annual Operating Margin has a five-year change of +115.30 percentage points (FY2020 to FY2025).
- Across earlier years, Operating Margin came in at -116.44% in FY2024 (-14.37 pp), -102.07% in FY2023 (+80.97 pp), -183.04% in FY2022 (-191.75 pp) and 8.71% in FY2021 (+141.67 pp).
- Quarterly Operating Margin has ranged from -266.66% in Q4 2021 to 74.14% in Q3 2021 over the past five years.
- On a year-over-year basis, Operating Margin has increased for six consecutive quarters, with an average year-over-year change of +68.23 percentage points over the last eight quarters.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 405.81 percentage points in Q2 2022, against a drop of 257.02 percentage points in Q3 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at 44.62% (Q1 2026), 42.09% (Q4 2025) and -15.03% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 37.40% |
| 10 | Agenus | 423.17 Mn | 416.40 Mn | 34.52 Mn | 32.72% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 32.72% |
| Mar 31, 2026 | 44.62% |
| Dec 31, 2025 | 42.09% |
| Sep 30, 2025 | -15.03% |
| Jun 30, 2025 | -65.05% |
| Mar 31, 2025 | -55.31% |
| Dec 31, 2024 | -96.49% |
| Sep 30, 2024 | -125.45% |
| Jun 30, 2024 | -128.43% |
| Mar 31, 2024 | -117.41% |
| Dec 31, 2023 | -5.01% |
| Sep 30, 2023 | -190.59% |
| Jun 30, 2023 | -216.11% |
| Mar 31, 2023 | -237.28% |
| Dec 31, 2022 | -203.47% |
| Sep 30, 2022 | -182.88% |
| Jun 30, 2022 | -212.96% |
| Mar 31, 2022 | -136.70% |
| Dec 31, 2021 | -266.66% |
| Sep 30, 2021 | 74.14% |
API Access
Agenus Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=AGEN&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "AGEN", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=AGEN&period=max&api_key=YOUR_API_KEY");
const data = await res.json();