Spruce Biosciences SPRB Institutional Ownership

NASDAQ SPRB

$41.23 +0.83 (+2.05%)

At close: Oct 20, 2026 · 4:00 PM EDT

Institutions by Trading Activity

64 Institutions

Increased 53 82.8%

Unchanged 8 12.5%

Reduced 3 4.7%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

72.87%

▲+46.87 pp QoQ

Shares Held by Institutions

2.01Mn

of 2.75Mn outstanding

▲+180.37% QoQ

Shares Outstanding

2.75Mn

746.86K held outside 13F filers

Institutional Investors

filed 13F for Jun 2026

▲+35 vs prior quarter

Net Shares Added (QoQ)

+1.29Mn

accumulated since last quarter

Value of Holdings

$83.19Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 10, 2026

Spruce Biosciences, Inc. (NASDAQ:SPRB) counted 64 institutional investors among its 13F-reported shareholders for the quarter ended June 30, 2026.

Together they owned 72.87% of the outstanding stock in Q2 2026, up from 26.00% a quarter earlier.
Total holdings of SPRB shares rose 180.37% from Q1 2026.
Looking at the 64 holders of SPRB individually, 53 added to their positions, 3 reduced their stakes and 8 left their positions unchanged.
Altogether, institutional holders owned 2.01Mn SPRB shares at the end of Q2 2026, up 1.29Mn from the prior quarter and up 1.98Mn from a year earlier.
AIGH Capital Management LLC led 13F holders of SPRB with 250K shares as of June 30, 2026, or 9.08% of shares outstanding.
Among existing holders, the largest additions to Spruce Biosciences in Q2 2026 came from BlackRock, Inc. (+170.9K shares), Geode Capital Management, LLC (+57.66K shares), Millennium Management LLC (+49.09K shares), State Street Corp (+45.05K shares) and Stempoint Capital LP (+35.03K shares).
Among holders that kept a stake in Spruce Biosciences, the biggest sellers in Q2 2026 were Balyasny Asset Management L.P. (-27.86K shares), Citadel Advisors LLC (-18.09K shares) and Jones Financial Companies LLLP (-163 shares).
Per Business Quant, the top 10 investors in SPRB for the quarter ended June 30, 2026 were AIGH Capital Management LLC (250K shares), OrbiMed Advisors LLC (200K shares), BlackRock, Inc. (187.84K shares), Millennium Management LLC (160.98K shares), Ikarian Capital, LLC (121.36K shares), Vanguard Capital Management LLC (119.33K shares), Alyeska Investment Group, L.P. (81.67K shares), Geode Capital Management, LLC (70.55K shares), ADAR1 Capital Management, LLC (67.72K shares) and Cable Car Capital, LP (60K shares).

Form 13F Holdings

64 Institutional Holders

Report period 30 Jun, 2026

Total shares held 2.01Mn

Of outstanding 72.87%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	AIGH Capital Management LLC	0001835943	250,000	9.08%	▲250,000	0.00%	$13.50Mn
2	ORBIMED ADVISORS LLC	0001055951	200,000	7.27%	▲200,000	0.00%	$10.80Mn
3	BlackRock, Inc.	0002012383	187,836	6.82%	▲170,898	+1,008.96%	$10.14Mn
4	MILLENNIUM MANAGEMENT LLC	0001273087	160,981	5.85%	▲49,093	+43.88%	$8.69Mn
5	Ikarian Capital, LLC	0001778253	121,356	4.41%	0	0.00%	$6.55Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	119,331	4.33%	▲119,331	0.00%	$6.44Mn
7	Alyeska Investment Group, L.P.	0001453072	81,671	2.97%	▲30,000	+58.06%	$4.41Mn
8	GEODE CAPITAL MANAGEMENT, LLC	0001214717	70,548	2.56%	▲57,659	+447.35%	$3.81Mn
9	ADAR1 Capital Management, LLC	0001940272	67,717	2.46%	▲9,117	+15.56%	$3.66Mn
10	Cable Car Capital, LP	0001699575	60,000	2.18%	▲60,000	0.00%	$3.24Mn
11	CITADEL ADVISORS LLC	0001423053	51,905	1.89%	▼18,094	-25.85%	$2.80Mn
12	State Street Corp	0000093751	50,450	1.83%	▲45,050	+834.26%	$2.72Mn
13	BOOTHBAY FUND MANAGEMENT, LLC	0001549230	42,080	1.53%	0	0.00%	$2.27Mn
14	STEMPOINT CAPITAL LP	0001952142	41,388	1.50%	▲35,028	+550.75%	$2.23Mn
15	Eversept Partners, LP	0001697013	40,000	1.45%	▲40,000	0.00%	$2.16Mn
16	Carlyle Group Inc.	0001527166	38,620	1.40%	0	0.00%	$2.09Mn
17	Goldman Sachs Group Inc	0000886982	32,348	1.18%	▲26,842	+487.50%	$1.75Mn
18	DIADEMA PARTNERS LP	0002026172	30,000	1.09%	▲20,000	+200.00%	$1.62Mn
18	Affinity Asset Advisors, LLC	0001773195	30,000	1.09%	▲30,000	0.00%	$1.62Mn
19	Stonepine Capital Management, LLC	0001440771	28,795	1.05%	▲28,795	0.00%	$1.55Mn

Showing 1 to 20 of 64 holders