Prelude Therapeutics PRLD Institutional Ownership

NASDAQ PRLD

$3.63 +0.10 (+2.83%)

As of: Oct 21, 2026 · 11:11 AM EDT

Institutions by Trading Activity

76 Institutions

Increased 60 78.9%

Unchanged 8 10.5%

Reduced 8 10.5%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

50.41%

▲+13.12 pp QoQ

Shares Held by Institutions

49.60Mn

of 98.39Mn outstanding

▲+61.18% QoQ

Shares Outstanding

98.39Mn

48.79Mn held outside 13F filers

Institutional Investors

filed 13F for Jun 2026

▲+21 vs prior quarter

Net Shares Added (QoQ)

+18.83Mn

accumulated since last quarter

Value of Holdings

$164.67Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Updated Oct 10, 2026

Prelude Therapeutics Inc (NASDAQ:PRLD) was reported as a holding by 76 institutional investors in 13F filings for the quarter ended June 30, 2026.

Together they owned 50.41% of the outstanding stock in Q2 2026, up from 37.29% a quarter earlier.
Total shares held in Prelude Therapeutics rose 61.18% from Q1 2026, while the number of holders rose 61.70% from Q2 2025.
Looking at the 76 holders of PRLD individually, 60 added to their positions, 8 reduced their stakes and 8 left their positions unchanged.
The aggregate institutional position in Prelude Therapeutics was 49.6Mn shares at the end of Q2 2026, up 18.83Mn from the prior quarter and up 22.73Mn from a year earlier.
As of June 30, 2026, OrbiMed Advisors LLC held the largest stake in Prelude Therapeutics with 13.72Mn shares, or 13.95% of shares outstanding.
Among existing holders, the largest additions to Prelude Therapeutics in Q2 2026 came from OrbiMed Advisors LLC (+2.82Mn shares), BlackRock, Inc. (+1.48Mn shares), Kynam Capital Management, LP (+822.54K shares), Vanguard Capital Management LLC (+779.04K shares) and ADAR1 Capital Management, LLC (+748.08K shares).
The biggest cuts to PRLD positions during Q2 2026 came from Marshall Wace, LLP (-168.21K shares), Goldman Sachs Group Inc (-115.64K shares), Citadel Advisors LLC (-101.82K shares), Bank of America Corp (-32.65K shares) and Qube Research & Technologies Ltd (-3.31K shares).
Per Business Quant data, the 10 largest holders of Prelude Therapeutics at the end of Q2 2026 were OrbiMed Advisors LLC (13.72Mn shares), Baker Bros. Advisors LP (10.12Mn shares), Ra Capital Management, L.P. (6.48Mn shares), Soleus Capital Management, L.P. (3.38Mn shares), Kynam Capital Management, LP (2.42Mn shares), Vanguard Capital Management LLC (2.01Mn shares), BlackRock, Inc. (1.8Mn shares), Sphera Funds Management LTD. (1.02Mn shares), Two Sigma Investments, LP (993.37K shares) and ADAR1 Capital Management, LLC (900.9K shares).

Form 13F Holdings

76 Institutional Holders

Report period 30 Jun, 2026

Total shares held 49.60Mn

Of outstanding 50.41%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	ORBIMED ADVISORS LLC	0001055951	13,724,571	13.95%	▲2,815,315	+25.81%	$73.15Mn
2	BAKER BROS. ADVISORS LP	0001263508	10,123,824	10.29%	0	0.00%	$53.96Mn
3	RA CAPITAL MANAGEMENT, L.P.	0001346824	6,475,882	6.58%	▲6,475,882	0.00%	$34.52Mn
4	Soleus Capital Management, L.P.	0001802630	3,378,378	3.43%	▲3,378,378	0.00%	$18.01Mn
5	Kynam Capital Management, LP	0001907884	2,415,087	2.45%	▲822,536	+51.65%	$12.87Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	2,009,445	2.04%	▲779,039	+63.32%	$10.71Mn
7	BlackRock, Inc.	0002012383	1,797,501	1.83%	▲1,475,615	+458.43%	$9.58Mn
8	SPHERA FUNDS MANAGEMENT LTD.	0001496201	1,019,832	1.04%	▲461,493	+82.65%	$5.44Mn
9	TWO SIGMA INVESTMENTS, LP	0001179392	993,369	1.01%	▲69,743	+7.55%	$5.29Mn
10	ADAR1 Capital Management, LLC	0001940272	900,900	0.92%	▲748,075	+489.50%	$4.80Mn
11	MILLENNIUM MANAGEMENT LLC	0001273087	844,993	0.86%	▲462,256	+120.78%	$4.50Mn
12	GEODE CAPITAL MANAGEMENT, LLC	0001214717	841,862	0.86%	▲539,404	+178.34%	$4.49Mn
13	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	766,095	0.78%	▲766,095	0.00%	$4.08Mn
14	ACADIAN ASSET MANAGEMENT LLC	0000916542	611,359	0.62%	▲99,840	+19.52%	$3.25K
15	Morgan Stanley	0000895421	503,860	0.51%	▲181,699	+56.40%	$2.69Mn
16	State Street Corp	0000093751	428,787	0.44%	▲290,556	+210.20%	$2.29Mn
17	UBS Group AG	0001610520	318,797	0.32%	▲254,292	+394.22%	$1.70Mn
18	VANGUARD FIDUCIARY TRUST CO	0000933478	284,886	0.29%	▲127,506	+81.02%	$1.52Mn
19	RENAISSANCE TECHNOLOGIES LLC	0001037389	281,200	0.29%	▲6,000	+2.18%	$1.50Mn
20	Northern Trust Corp	0000073124	240,599	0.24%	▲190,479	+380.05%	$1.28Mn

Showing 1 to 20 of 76 holders