Upstream Bio (UPB) Share-based Compensation (2023 - 2026)

Upstream Bio (UPB) posted quarterly Share-based Compensation of $43.4 million for Q1 2026, up 1547.06% year-over-year from $2.6 million in Q1 2025, and up 654.56% quarter-over-quarter from -$7.8 million in Q4 2025.

Upstream Bio (UPB) Share-based Compensation (2023 - 2026) Analysis & Trends

Upstream Bio's Share-based Compensation history runs 4 years deep, the most recent figure standing at $43.4 million for Q1 2026.

  • In Q1 2026, Share-based Compensation rose 1547.06% year-over-year to $43.4 million; the TTM figure through Mar 2026 stood at $43.4 million (up 442.77% YoY), while the FY2025 annual figure was $21.4 million, up 37.18% from the prior year.
  • Share-based Compensation for Q1 2026 stood at $43.4 million, up from -$7.8 million in the prior quarter.
  • The five-year high for Share-based Compensation was $43.4 million in Q1 2026, with the low at -$7.8 million in Q4 2025.
  • The 4-year median for Share-based Compensation is $1.9 million (2024), against an average of $8.5 million.
  • Peak annual rise in Share-based Compensation reached 1628.05% in 2025, while the deepest fall reached 475.17% in 2025.
  • Upstream Bio's Share-based Compensation stood at $711000.0 in 2023, then soared by 193.39% to $2.1 million in 2024, then plunged by 475.17% to -$7.8 million in 2025, then soared by 654.56% to $43.4 million in 2026.
  • Business Quant data shows UPB's Share-based Compensation at $43.4 million in Q1 2026, -$7.8 million in Q4 2025, and $23.0 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Share-based Compensation (Qtr)
1 Vertex Pharmaceuticals 128.13 Bn 120.28 Bn 2.84 Bn 108.10 Mn
2 Regeneron Pharmaceuticals 112.33 Bn 104.33 Bn 3.93 Bn 243.00 Mn
3 Argenx Se 53.24 Bn 48.05 Bn 1.41 Bn -
4 Revolution Medicines 43.64 Bn 43.64 Bn - 277.20 Mn
5 BeOne Medicines 39.27 Bn 34.17 Bn 1.53 Bn 137.41 Mn
6 MindWalk Holdings 35.32 Bn 35.31 Bn 1.82 Bn 590,899.88
7 Royalty Pharma 33.72 Bn 35.84 Bn - -
8 Alnylam Pharmaceuticals 30.58 Bn 27.27 Bn 992.69 Mn 86.63 Mn
9 Insmed 27.01 Bn 25.85 Bn 358.27 Mn 41.25 Mn
10 Upstream Bio 387.23 Mn 387.23 Mn -3.29 Mn 39.70 Mn

Historic Data

Download Data
DateValue
Jun 30, 2026 39.70 Mn
Jun 30, 2026 39.70 Mn
Mar 31, 2026 43.40 Mn
Mar 31, 2026 43.40 Mn
Dec 31, 2025 -7.83 Mn
Dec 31, 2025 -7.83 Mn
Sep 30, 2025 23.00 Mn
Sep 30, 2025 23.00 Mn
Jun 30, 2025 24.40 Mn
Jun 30, 2025 24.40 Mn
Mar 31, 2025 2.64 Mn
Mar 31, 2025 2.64 Mn
Dec 31, 2024 2.09 Mn
Dec 31, 2024 2.09 Mn
Sep 30, 2024 1.86 Mn
Sep 30, 2024 1.86 Mn
Jun 30, 2024 1.41 Mn
Jun 30, 2024 1.41 Mn
Mar 31, 2024 643,000.00
Mar 31, 2024 643,000.00