Syndax Pharmaceuticals (SNDX) Operating Margin (2015 - 2026)
Syndax Pharmaceuticals (SNDX) posted Operating Margin of -54.95% for Q2 2026, up 127.76 percentage points from -182.71% a year earlier but down 2.22 percentage points from the prior quarter.
Syndax Pharmaceuticals (SNDX) Operating Margin (2015 - 2026) Analysis & Trends
For the trailing twelve months through Jun 30, 2026, Operating Margin at Syndax Pharmaceuticals was -76.98%, up 356.71 percentage points year-over-year; for FY2025, it was -158.45%, up 1275.98 percentage points from FY2024.
- Annual Operating Margin shows a five-year change of +4549.73 percentage points (FY2020 to FY2025).
- In prior years, Syndax Pharmaceuticals' Operating Margin was -1434.43% in FY2024 and 18.77% in FY2021 (+4726.94 pp).
- Quarterly Operating Margin has run from a low of -2120.46% in Q2 2024 to a high of 75.65% in Q4 2021 over five years.
- On a year-over-year basis, Operating Margin has increased in each of the last five quarters, with an average year-over-year change of +837.17 percentage points over the last five quarters.
- According to Business Quant data, Operating Margin for the three prior quarters was -52.73% (Q1 2026), -91.01% (Q4 2025) and -125.19% (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 37.40% |
| 10 | Syndax Pharmaceuticals | 1.68 Bn | -53.94 Mn | 69.58 Mn | -54.95% |
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -54.95% |
| Mar 31, 2026 | -52.73% |
| Dec 31, 2025 | -91.01% |
| Sep 30, 2025 | -125.19% |
| Jun 30, 2025 | -182.71% |
| Mar 31, 2025 | -417.91% |
| Dec 31, 2024 | -1,254.75% |
| Sep 30, 2024 | -716.62% |
| Jun 30, 2024 | -2,120.46% |
| Dec 31, 2021 | 75.65% |
| Sep 30, 2021 | -161.87% |
| Jun 30, 2021 | -5,892.88% |
| Mar 31, 2021 | -7,167.02% |
| Dec 31, 2020 | -5,226.32% |
| Sep 30, 2020 | -5,238.26% |
| Jun 30, 2020 | -4,382.59% |
| Mar 31, 2020 | -3,984.17% |
| Dec 31, 2019 | -3,738.16% |
| Sep 30, 2019 | -3,469.39% |
| Jun 30, 2019 | -4,056.46% |
Syndax Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=SNDX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "SNDX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=SNDX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();