Septerna (SEPN) Operating Expenses (2023 - 2026)

Septerna (SEPN) recorded quarterly Operating Expenses of $6.2 million in Q1 2026, down 84.66% quarter-over-quarter from $40.1 million in Q4 2025, and up 25.35% on a YoY basis from $4.9 million in Q1 2025.

Septerna (SEPN) Operating Expenses (2023 - 2026) Analysis & Trends

Septerna's Operating Expenses history runs 4 years deep, the most recent figure standing at $6.2 million for Q1 2026.

  • In Q1 2026, Operating Expenses rose 25.35% year-over-year to $6.2 million; the TTM figure through Mar 2026 stood at $94.3 million (down 18.68% YoY), while the FY2025 annual figure was $114.2 million, up 39.5% from the prior year.
  • Operating Expenses was $6.2 million for Q1 2026 at Septerna, down from $40.1 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $69.9 million in Q4 2024 to a low of -$34.2 million in Q4 2023.
  • Historically, Operating Expenses has averaged $18.5 million across 4 years, with a median of $18.4 million in 2024.
  • The sharpest annual moves came in 2024 and 2025: Operating Expenses jumped 304.29% in 2024, then sank 68.93% in 2025.
  • A 4-year view of Operating Expenses shows it stood at -$34.2 million in 2023, then surged by 304.29% to $69.9 million in 2024, then sank by 42.55% to $40.1 million in 2025, then plunged by 84.66% to $6.2 million in 2026.
  • The last three Operating Expenses figures came in at $6.2 million (Q1 2026), $40.1 million (Q4 2025), and $18.9 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 Septerna 1.62 Bn 1.62 Bn - 6.16 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 6.16 Mn
Dec 31, 2025 40.14 Mn
Sep 30, 2025 18.88 Mn
Jun 30, 2025 29.10 Mn
Mar 31, 2025 4.91 Mn
Dec 31, 2024 69.87 Mn
Sep 30, 2024 22.73 Mn
Jun 30, 2024 18.44 Mn
Mar 31, 2024 15.81 Mn
Dec 31, 2023 -34.20 Mn
Sep 30, 2023 12.07 Mn