Septerna (SEPN) Operating Expenses (2023 - 2026)

Septerna's quarterly Operating Expenses came in at $6.2 million in Q1 2026, up 25.35% year-on-year from $4.9 million in Q1 2025, and down 84.66% quarter-over-quarter from $40.1 million in Q4 2025.

Septerna has reported Operating Expenses for 4 years, with the latest figure at $6.2 million in Q1 2026.

  • For the quarter ending Q1 2026, Operating Expenses rose 25.35% year-over-year to $6.2 million; the trailing twelve-month figure through Mar 2026 stood at $94.3 million (down 18.68% YoY), and the FY2025 full-year result was $114.2 million, up 39.5% from the prior year.
  • Operating Expenses for Q1 2026 stood at $6.2 million, down from $40.1 million in the prior quarter.
  • The five-year high for Operating Expenses was $69.9 million in Q4 2024, with the low at -$34.2 million in Q4 2023.
  • Average Operating Expenses over 4 years is $18.5 million, with a median of $18.4 million recorded in 2024.
  • Year-over-year, Operating Expenses soared 304.29% in 2024 and sank 68.93% in 2025.
  • Tracing SEPN's Operating Expenses over 4 years: stood at -$34.2 million in 2023, then soared by 304.29% to $69.9 million in 2024, then plunged by 42.55% to $40.1 million in 2025, then tumbled by 84.66% to $6.2 million in 2026.
  • The last three Operating Expenses figures came in at $6.2 million (Q1 2026), $40.1 million (Q4 2025), and $18.9 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.97 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - 4.33 Mn
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -138.30 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 15.76 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.85 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 2.96 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 898.54 Mn
10 Septerna 1.34 Bn 1.34 Bn - 6.16 Mn

Historic Data

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DateValue
Mar 31, 2026 6.16 Mn
Dec 31, 2025 40.14 Mn
Sep 30, 2025 18.88 Mn
Jun 30, 2025 29.10 Mn
Mar 31, 2025 4.91 Mn
Dec 31, 2024 69.87 Mn
Sep 30, 2024 22.73 Mn
Jun 30, 2024 18.44 Mn
Mar 31, 2024 15.81 Mn
Dec 31, 2023 -34.20 Mn
Sep 30, 2023 12.07 Mn