Prime Medicine (PRME) Operating Expenses (2021 - 2026)
Prime Medicine (PRME) posted Operating Expenses of $51.5 million for Q1 2026, up 4.17% on a QoQ basis from $49.4 million in Q4 2025, and down 4.34% year-over-year from $53.8 million in Q1 2025.
Prime Medicine (PRME) Operating Expenses (2021 - 2026) Analysis & Trends
Prime Medicine's Operating Expenses history runs 6 years deep, the most recent figure standing at $51.5 million for Q1 2026.
- Quarterly Operating Expenses fell 4.34% year-over-year to $51.5 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $210.6 million (changed 0.13% YoY) and the FY2025 annual result came in at $213.0 million, up 3.67% from the prior year.
- Operating Expenses was $51.5 million for Q1 2026 at Prime Medicine, up from $49.4 million in the prior quarter.
- Across five years, Operating Expenses topped out at $68.0 million in Q4 2023 and bottomed at $19.9 million in Q1 2022.
- A 5-year average of $46.5 million and a median of $49.4 million in 2025 frame the typical range for Operating Expenses.
- Peak annual rise in Operating Expenses reached 203.59% in 2022, while the deepest fall reached 35.6% in 2022.
- Prime Medicine's Operating Expenses stood at $38.7 million in 2022, then jumped by 75.89% to $68.0 million in 2023, then plunged by 31.8% to $46.4 million in 2024, then climbed by 6.55% to $49.4 million in 2025, then increased by 4.17% to $51.5 million in 2026.
- Business Quant data shows PRME's Operating Expenses at $51.5 million in Q1 2026, $49.4 million in Q4 2025, and $55.2 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -28.01 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | 15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 1.10 Bn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.85 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 2.96 Bn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | 32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | -919.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | 445.22 Mn |
| 10 | Prime Medicine | 524.20 Mn | 524.20 Mn | - | 51.51 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 51.51 Mn |
| Dec 31, 2025 | 49.45 Mn |
| Sep 30, 2025 | 55.20 Mn |
| Jun 30, 2025 | 54.49 Mn |
| Mar 31, 2025 | 53.85 Mn |
| Dec 31, 2024 | 46.41 Mn |
| Sep 30, 2024 | 54.44 Mn |
| Jun 30, 2024 | 55.67 Mn |
| Mar 31, 2024 | 48.93 Mn |
| Dec 31, 2023 | 68.04 Mn |
| Sep 30, 2023 | 51.46 Mn |
| Jun 30, 2023 | 45.26 Mn |
| Mar 31, 2023 | 40.03 Mn |
| Dec 31, 2022 | 38.69 Mn |
| Sep 30, 2022 | 31.66 Mn |
| Jun 30, 2022 | 26.31 Mn |
| Mar 31, 2022 | 19.90 Mn |
| Dec 31, 2021 | 60.08 Mn |
| Sep 30, 2021 | 10.43 Mn |