Prime Medicine (PRME) Operating Expenses (2021 - 2026)

Prime Medicine (PRME) reported Operating Expenses of $51.5 million for Q1 2026, down 4.34% on a YoY basis from $53.8 million in Q1 2025, and up 4.17% quarter-over-quarter from $49.4 million in Q4 2025.

Prime Medicine (PRME) Operating Expenses (2021 - 2026) Analysis & Trends

Prime Medicine has reported Operating Expenses for 6 years, with the latest figure at $51.5 million in Q1 2026.

  • For the quarter ending Q1 2026, Operating Expenses fell 4.34% year-over-year to $51.5 million; the trailing twelve-month figure through Mar 2026 stood at $210.6 million (changed 0.13% YoY), and the FY2025 full-year result was $213.0 million, up 3.67% from the prior year.
  • Operating Expenses for Q1 2026 stood at $51.5 million, up from $49.4 million in the prior quarter.
  • The five-year high for Operating Expenses was $68.0 million in Q4 2023, with the low at $19.9 million in Q1 2022.
  • Historically, Operating Expenses has averaged $46.5 million across 5 years, with a median of $49.4 million in 2025.
  • The largest YoY upside for Operating Expenses was 203.59% in 2022 against a maximum downside of 35.6% in 2022.
  • Prime Medicine's Operating Expenses stood at $38.7 million in 2022, then surged by 75.89% to $68.0 million in 2023, then slumped by 31.8% to $46.4 million in 2024, then gained by 6.55% to $49.4 million in 2025, then climbed by 4.17% to $51.5 million in 2026.
  • The last three Operating Expenses figures came in at $51.5 million (Q1 2026), $49.4 million (Q4 2025), and $55.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 Prime Medicine 572.02 Mn 572.02 Mn - 51.51 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 51.51 Mn
Dec 31, 2025 49.45 Mn
Sep 30, 2025 55.20 Mn
Jun 30, 2025 54.49 Mn
Mar 31, 2025 53.85 Mn
Dec 31, 2024 46.41 Mn
Sep 30, 2024 54.44 Mn
Jun 30, 2024 55.67 Mn
Mar 31, 2024 48.93 Mn
Dec 31, 2023 68.04 Mn
Sep 30, 2023 51.46 Mn
Jun 30, 2023 45.26 Mn
Mar 31, 2023 40.03 Mn
Dec 31, 2022 38.69 Mn
Sep 30, 2022 31.66 Mn
Jun 30, 2022 26.31 Mn
Mar 31, 2022 19.90 Mn
Dec 31, 2021 60.08 Mn
Sep 30, 2021 10.43 Mn