Prime Medicine (PRME) Operating Expenses (2021 - 2026)

Prime Medicine (PRME) posted Operating Expenses of $51.5 million for Q1 2026, up 4.17% on a QoQ basis from $49.4 million in Q4 2025, and down 4.34% year-over-year from $53.8 million in Q1 2025.

Prime Medicine (PRME) Operating Expenses (2021 - 2026) Analysis & Trends

Prime Medicine's Operating Expenses history runs 6 years deep, the most recent figure standing at $51.5 million for Q1 2026.

  • Quarterly Operating Expenses fell 4.34% year-over-year to $51.5 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was $210.6 million (changed 0.13% YoY) and the FY2025 annual result came in at $213.0 million, up 3.67% from the prior year.
  • Operating Expenses was $51.5 million for Q1 2026 at Prime Medicine, up from $49.4 million in the prior quarter.
  • Across five years, Operating Expenses topped out at $68.0 million in Q4 2023 and bottomed at $19.9 million in Q1 2022.
  • A 5-year average of $46.5 million and a median of $49.4 million in 2025 frame the typical range for Operating Expenses.
  • Peak annual rise in Operating Expenses reached 203.59% in 2022, while the deepest fall reached 35.6% in 2022.
  • Prime Medicine's Operating Expenses stood at $38.7 million in 2022, then jumped by 75.89% to $68.0 million in 2023, then plunged by 31.8% to $46.4 million in 2024, then climbed by 6.55% to $49.4 million in 2025, then increased by 4.17% to $51.5 million in 2026.
  • Business Quant data shows PRME's Operating Expenses at $51.5 million in Q1 2026, $49.4 million in Q4 2025, and $55.2 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -28.01 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - 15.76 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 1.10 Bn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.85 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 2.96 Bn
7 Belite Bio 61.40 Bn 61.40 Bn - 32.68 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -919.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - 445.22 Mn
10 Prime Medicine 524.20 Mn 524.20 Mn - 51.51 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 51.51 Mn
Dec 31, 2025 49.45 Mn
Sep 30, 2025 55.20 Mn
Jun 30, 2025 54.49 Mn
Mar 31, 2025 53.85 Mn
Dec 31, 2024 46.41 Mn
Sep 30, 2024 54.44 Mn
Jun 30, 2024 55.67 Mn
Mar 31, 2024 48.93 Mn
Dec 31, 2023 68.04 Mn
Sep 30, 2023 51.46 Mn
Jun 30, 2023 45.26 Mn
Mar 31, 2023 40.03 Mn
Dec 31, 2022 38.69 Mn
Sep 30, 2022 31.66 Mn
Jun 30, 2022 26.31 Mn
Mar 31, 2022 19.90 Mn
Dec 31, 2021 60.08 Mn
Sep 30, 2021 10.43 Mn