Prelude Therapeutics (PRLD) Operating Expenses (2019 - 2026)

Prelude Therapeutics' (PRLD) quarterly Operating Expenses came in at $18.8 million in Q1 2026, down 45.8% year-on-year from $34.6 million in Q1 2025, and down 18.41% quarter-over-quarter from $23.0 million in Q4 2025.

Prelude Therapeutics (PRLD) Operating Expenses (2019 - 2026) Analysis & Trends

Prelude Therapeutics has disclosed Operating Expenses across 8 years of filings, most recently posting $18.8 million for Q1 2026.

  • Operating Expenses for Q1 2026 came in at $18.8 million, down 45.8% year-over-year; the trailing twelve-month figure through Mar 2026 was $100.9 million (down 31.38% YoY), and the FY2025 annual result was $116.7 million, down 20.45% from the prior year.
  • Operating Expenses came in at $18.8 million for Q1 2026 at Prelude Therapeutics, down from $23.0 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $37.8 million in Q4 2024 to a low of $18.8 million in Q1 2026.
  • The 5-year median for Operating Expenses is $32.4 million (2023), against an average of $31.6 million.
  • Across the five-year window, Operating Expenses soared 37.88% in 2022 and plunged 45.8% in 2026, its largest moves.
  • Prelude Therapeutics' Operating Expenses stood at $33.4 million in 2022, then rose by 11.96% to $37.4 million in 2023, then climbed by 1.21% to $37.8 million in 2024, then tumbled by 39.24% to $23.0 million in 2025, then fell by 18.41% to $18.8 million in 2026.
  • The last three Operating Expenses figures came in at $18.8 million (Q1 2026), $23.0 million (Q4 2025), and $26.9 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - 4.33 Mn
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - 32.68 Mn
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - 2.97 Mn
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn -138.30 Mn
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - 15.76 Mn
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -3.82 Mn
7 Psyence Biomedical 241.78 Bn 241.78 Bn - 574,669.00
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 1.85 Bn
9 Abivax 94.26 Bn 94.26 Bn - -67.40 Mn
10 Prelude Therapeutics 314.40 Mn 169.80 Mn - 18.76 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 18.76 Mn
Dec 31, 2025 22.99 Mn
Sep 30, 2025 26.92 Mn
Jun 30, 2025 32.19 Mn
Mar 31, 2025 34.61 Mn
Dec 31, 2024 37.83 Mn
Sep 30, 2024 37.38 Mn
Jun 30, 2024 37.16 Mn
Mar 31, 2024 34.34 Mn
Dec 31, 2023 37.38 Mn
Sep 30, 2023 33.39 Mn
Jun 30, 2023 32.40 Mn
Mar 31, 2023 29.12 Mn
Dec 31, 2022 33.39 Mn
Sep 30, 2022 30.41 Mn
Jun 30, 2022 29.46 Mn
Mar 31, 2022 30.29 Mn
Dec 31, 2021 33.01 Mn
Sep 30, 2021 30.84 Mn
Jun 30, 2021 27.92 Mn