Madrigal Pharmaceuticals (MDGL) Operating Margin (2010 - 2026)
Madrigal Pharmaceuticals' Operating Margin was -15.46% in Q2 2026, up 6.72 percentage points from -22.18% a year earlier and up 14.32 percentage points from the prior quarter.
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Analysis
Madrigal Pharmaceuticals (MDGL) Operating Margin (2010 - 2026) Analysis & Trends
On a trailing twelve-month basis, Madrigal Pharmaceuticals' Operating Margin was -25.13% through Jun 30, 2026, up 34.97 percentage points year-over-year; for FY2025, it was -31.31%, up 245.08 percentage points from FY2024.
- In earlier years, Operating Margin was -276.39% in FY2024.
- The Q2 2026 figure marks the highest quarterly Operating Margin in data going back to Q2 2010.
- Compared with a year earlier, Operating Margin has increased for five straight quarters, with an average year-over-year change of +263.32 percentage points over the last five quarters.
- Per Business Quant data, MDGL's Operating Margin in the three quarters before Q2 2026 was -29.78% (Q1 2026), -18.56% (Q4 2025) and -39.68% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Madrigal Pharmaceuticals | 15.07 Bn | 11.32 Bn | - | -15.46% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -15.46% |
| Mar 31, 2026 | -29.78% |
| Dec 31, 2025 | -18.56% |
| Sep 30, 2025 | -39.68% |
| Jun 30, 2025 | -22.18% |
| Mar 31, 2025 | -57.79% |
| Dec 31, 2024 | -64.84% |
| Sep 30, 2024 | -187.06% |
| Jun 30, 2024 | -1,110.38% |
| Mar 31, 2012 | -9,908.16% |
| Dec 31, 2011 | -299.12% |
| Sep 30, 2011 | -734.25% |
| Jun 30, 2011 | -886.93% |
| Mar 31, 2011 | -959.41% |
| Dec 31, 2010 | -207.21% |
| Sep 30, 2010 | -302.42% |
| Jun 30, 2010 | -269.17% |
API Access
Madrigal Pharmaceuticals Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=MDGL&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "MDGL", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=MDGL&period=max&api_key=YOUR_API_KEY");
const data = await res.json();