International Stem Cell (ISCO) EV to FCF (2010 - 2025)
International Stem Cell's (ISCO) quarterly EV to FCF came in at 4.4 in Q4 2025, down 44.03% year-over-year from 7.86 in Q4 2024, and up 171.45% quarter-over-quarter from 1.62 in Q3 2025.
Analysis
International Stem Cell (ISCO) EV to FCF (2010 - 2025) Analysis & Trends
International Stem Cell (ISCO) has reported EV to FCF for 16 consecutive years, with 4.4 the latest figure, recorded in Q4 2025.
- On a quarterly basis, EV to FCF fell 44.03% year-over-year to 4.4 in Q4 2025; TTM through Dec 2025 was 3.65, a 194.61% decrease from a year earlier, with the FY2025 full-year figure at 3.65, down 194.61% from the prior year.
- EV to FCF was 4.4 for Q4 2025 at International Stem Cell, up from 1.62 in the prior quarter.
- Over five years, EV to FCF peaked at 27.33 in Q3 2022 and troughed at 149.74 in Q1 2022.
- A 5-year average of 7.4 and a median of 0.93 in 2023 frame the typical range for EV to FCF.
- Across the five-year window, EV to FCF slumped 1245.0% in 2022 and jumped 1173.34% in 2024, its largest moves.
- Over 5 years, EV to FCF stood at 11.02 in 2021, then soared by 180.3% to 8.85 in 2022, then sank by 177.78% to 6.88 in 2023, then jumped by 214.27% to 7.86 in 2024, then tumbled by 44.03% to 4.4 in 2025.
- The last three EV to FCF figures came in at 4.4 (Q4 2025), 1.62 (Q3 2025), and 1.09 (Q2 2025), per Business Quant data.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) |
|---|---|---|---|---|
| 1 | Krystal Biotech | 10.27 Bn | 9.43 Bn | 112.79 Mn |
| 2 | CRISPR Therapeutics AG | 5.17 Bn | 5.17 Bn | - |
| 3 | Iovance Biotherapeutics | 3.79 Bn | 3.49 Bn | 55.72 Mn |
| 4 | Legend Biotech | 3.68 Bn | 2.71 Bn | 251.50 Mn |
| 5 | uniQure | 3.05 Bn | 3.05 Bn | 5.49 Mn |
| 6 | Beam Therapeutics | 2.65 Bn | 2.65 Bn | - |
| 7 | Precigen | 2.44 Bn | 2.44 Bn | 52.17 Mn |
| 8 | Sarepta Therapeutics | 2.33 Bn | 1.53 Bn | 251.87 Mn |
| 9 | Vericel | 1.99 Bn | 1.83 Bn | 56.40 Mn |
| 10 | International Stem Cell | 2.84 Mn | 1.75 Mn | 1.46 Mn |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | 4.40 |
| Sep 30, 2025 | 1.62 |
| Jun 30, 2025 | -1.09 |
| Mar 31, 2025 | -2.21 |
| Dec 31, 2024 | 7.86 |
| Sep 30, 2024 | -3.76 |
| Jun 30, 2024 | 8.35 |
| Mar 31, 2024 | 2.91 |
| Dec 31, 2023 | -6.88 |
| Sep 30, 2023 | -9.78 |
| Jun 30, 2023 | -0.78 |
| Mar 31, 2023 | 2.48 |
| Dec 31, 2022 | 8.85 |
| Sep 30, 2022 | 27.33 |
| Jun 30, 2022 | 14.04 |
| Mar 31, 2022 | -149.74 |
| Dec 31, 2021 | -11.02 |
| Sep 30, 2021 | -16.68 |
| Jun 30, 2021 | -12.71 |
| Mar 31, 2021 | -11.13 |