Denali Therapeutics (DNLI) Operating Margin (2018 - 2026)
Denali Therapeutics (DNLI) recorded Operating Margin of -3622.11% in Q2 2026.
Powered by 
Analysis
Denali Therapeutics (DNLI) Operating Margin (2018 - 2026) Analysis & Trends
On a TTM basis, Denali Therapeutics' Operating Margin came in at -15058.19% as of Jun 30, 2026; for FY2023, it was -59.51%, up 254.65 percentage points from FY2022.
- Annual Operating Margin has a five-year change of -23.61 percentage points (FY2018 to FY2023).
- Across earlier years, Operating Margin came in at -314.16% in FY2022 (+293.62 pp), -607.78% in FY2021 (-626.46 pp), 18.69% in FY2020 (+817.79 pp) and -799.10% in FY2019 (-763.20 pp).
- The Q2 2026 figure is the highest quarterly Operating Margin since Q2 2023.
- Peak year-over-year performance for Operating Margin in the last five years was a gain of 741.10 percentage points in Q1 2022, against a drop of 5961.33 percentage points in Q3 2023 at the low end.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Denali Therapeutics | 3.35 Bn | 3.35 Bn | 3.51 Mn | -3,622.11% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -3,622.11% |
| Sep 30, 2023 | -8,981.45% |
| Jun 30, 2023 | 57.96% |
| Mar 31, 2023 | -343.80% |
| Dec 31, 2022 | -1,024.45% |
| Sep 30, 2022 | -3,020.12% |
| Jun 30, 2022 | -117.03% |
| Mar 31, 2022 | -157.80% |
| Dec 31, 2021 | -616.28% |
| Sep 30, 2021 | -1,619.55% |
| Jun 30, 2021 | -269.48% |
| Mar 31, 2021 | -898.90% |
| Dec 31, 2020 | 77.04% |
| Sep 30, 2020 | -640.01% |
| Jun 30, 2020 | -1,048.01% |
| Mar 31, 2020 | -1,663.90% |
| Dec 31, 2019 | -1,236.26% |
| Sep 30, 2019 | -368.68% |
| Jun 30, 2019 | -1,495.43% |
| Mar 31, 2019 | -1,010.89% |
API Access
Denali Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=DNLI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "DNLI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=DNLI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();