Denali Therapeutics Inc. (DNLI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

171,489,189Shares Outstanding

6,082,010Shares held by institutions

$117,261,153Value of institutional holdings

81.78%Institutional ownership %

10.17%Shares Changed QoQ

240No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Denali Therapeutics Inc. (NASDAQ:DNLI) currently has 240 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

Denali Therapeutics saw its institutional ownership percentage rose to 81.8% in December 2025 from 79.1% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 10.17%, with a year-over-year an increase of 7.14% in the count of filers.
Of these 240 institutional investors, 132 increased their holdings in Denali Therapeutics, while 68 of them reduced positions, and 40 investors maintained their exposure.
Collectively, institutional investors increased their stake in Denali Therapeutics to 140.24Mn shares as of December 2025, a change that is up by 12.95Mn shares quarter on quarter and up 12.57Mn shares year over year.
As of December 31, 2025, VANGUARD GROUP INC held Denali Therapeutics's largest shareholding position with over 13.06Mn shares, representing 7.61% of total outstanding shares.
Among the most significant buyers of Denali Therapeutics during December 2025 were NORGES BANK (5.12Mn), GOLDMAN SACHS GROUP INC (1.67Mn), Temasek Holdings (Private) Ltd (1.66Mn), Lynx1 Capital Management LP (1.48Mn), VANGUARD GROUP INC (1.06Mn).
Leading sellers of Denali Therapeutics stock in December 2025 included T. Rowe Price Investment Management, Inc. (4.39Mn), STEMPOINT CAPITAL LP (1.32Mn), Capital Research Global Investors (1.03Mn), MILLENNIUM MANAGEMENT LLC (937.40K), Point72 Asset Management, L.P. (819.53K).
The top 10 institutional holders of Denali Therapeutics for the quarter ending December 2025 included VANGUARD GROUP INC (13.06Mn), BlackRock, Inc. (12.71Mn), BAILLIE GIFFORD & CO (12.31Mn), Temasek Holdings (Private) Ltd (7.01Mn), STATE STREET CORP (6.26Mn), FMR LLC (6.10Mn), NORGES BANK (5.12Mn), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (4.98Mn), GOLDMAN SACHS GROUP INC (3.84Mn), BAKER BROS. ADVISORS LP (3.73Mn).

240 Institutional Holders

6,082,010 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
VANGUARD GROUP INC	31 Dec, 2025	13,057,890	1,064,972	8.88%	$215,585,764.00
BlackRock, Inc.	31 Dec, 2025	12,714,882	425,575	3.46%	$209,922,701.00
BAILLIE GIFFORD & CO	31 Dec, 2025	12,310,889	719,304	6.21%	$203,252,777.00
Temasek Holdings (Private) Ltd	31 Dec, 2025	7,012,974	1,657,142	30.94%	$115,784,201.00
STATE STREET CORP	31 Dec, 2025	6,263,371	799,110	14.62%	$103,408,255.00
FMR LLC	31 Dec, 2025	6,097,211	-243,105	-3.83%	$100,664,952.00
NORGES BANK	31 Dec, 2025	5,119,622	5,119,622	0.00%	$84,524,959.00
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	31 Dec, 2025	4,983,726	-481,311	-8.81%	$82,281,317.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	3,835,803	1,672,098	77.28%	$63,329,108.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	3,731,695	0	0.00%	$61,610,284.00
Capital Research Global Investors	31 Dec, 2025	3,729,244	-1,031,614	-21.67%	$61,569,818.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	3,557,935	37,521	1.07%	$58,741,507.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	3,458,131	-7,926	-0.23%	$57,104,172.00
Holocene Advisors, LP	31 Dec, 2025	3,152,734	17,022	0.54%	$52,051,638.00
Crestline Management, LP	31 Dec, 2025	2,810,732	-600,000	-17.59%	$46,405,185.00
Fisher Asset Management, LLC	31 Dec, 2025	2,589,403	957,907	58.71%	$42,751,042.00
UBS Group AG	31 Dec, 2025	2,404,704	392,351	19.50%	$39,701,663.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	2,374,303	17,089	0.72%	$39,198,394.00
Aberdeen Group plc	31 Dec, 2025	2,032,967	919,381	82.56%	$33,564,285.00
Casdin Capital, LLC	31 Dec, 2025	1,840,000	950,000	106.74%	$30,378,400.00

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