Denali Therapeutics Inc. (DNLI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

172,421,492Shares Outstanding

151,856,531Shares held by institutions

$3,143,430,192Value of institutional holdings

88.07%Institutional ownership %

16.93%Shares Changed QoQ

246No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Denali Therapeutics Inc. (NASDAQ:DNLI) has 246 institutional investors that have filed 13F reports for the period ending December 2025.

Their combined ownership stood at 85.8% of outstanding shares in December 2025, up from 79.6% in September 2025.
They increased total shares held in DNLI by 14.59% quarter over quarter, and investors in Denali Therapeutics increased 9.82% from a year ago.
Activity in DNLI broke down as 135 buyers, 69 sellers, and 42 unchanged among 246 total holders.
The aggregate institutional position in Denali Therapeutics amounted to 148.02Mn shares as of December 2025, up by 18.84Mn shares quarter on quarter, and up 17.76Mn shares year over year.
VANGUARD GROUP INC leads ownership in DNLI with 13.06Mn shares as of December 31, 2025, equal to 7.57% of outstanding shares.
The largest buyers of Denali Therapeutics for the quarter ending December 2025 were Goldman Sachs Group Inc (5.51Mn), NORGES BANK (5.12Mn), T. Rowe Price Investment Management, Inc. (2.86Mn), Temasek Holdings (Private) Ltd (1.66Mn), Lynx1 Capital Management LP (1.48Mn).
Leading sellers of Denali Therapeutics shares for the quarter ending December 2025 were STEMPOINT CAPITAL LP (1.32Mn), Capital Research Global Investors (1.03Mn), Bank Of America Corp /De/ (990.13K), MILLENNIUM MANAGEMENT LLC (937.4K), Point72 Asset Management, L.P. (819.54K).
Denali Therapeutics's 10 largest shareholders as of December 2025 include VANGUARD GROUP INC (13.06Mn), BlackRock, Inc. (12.71Mn), BAILLIE GIFFORD & CO (12.31Mn), T. Rowe Price Investment Management, Inc. (8.5Mn), Goldman Sachs Group Inc (7.67Mn), Temasek Holdings (Private) Ltd (7.01Mn), State Street Corp (6.26Mn), FMR LLC (6.1Mn), NORGES BANK (5.12Mn), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (4.98Mn) per Business Quant data.

246 Institutional Holders

151,856,531 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
VANGUARD GROUP INC	31 Dec, 2025	13,057,890	1,064,972	8.88%	$215,585,764.00
BlackRock, Inc.	31 Dec, 2025	12,714,882	425,575	3.46%	$209,922,701.00
BAILLIE GIFFORD & CO	31 Dec, 2025	12,310,889	719,304	6.21%	$203,252,777.00
T. Rowe Price Investment Management, Inc.	31 Dec, 2025	8,500,126	2,861,559	50.75%	$140,338.00
Goldman Sachs Group Inc	31 Dec, 2025	7,671,606	5,507,901	254.56%	$126,658,216.00
Temasek Holdings (Private) Ltd	31 Dec, 2025	7,012,974	1,657,142	30.94%	$115,784,201.00
State Street Corp	31 Dec, 2025	6,263,371	799,110	14.62%	$103,408,255.00
FMR LLC	31 Dec, 2025	6,097,211	-243,105	-3.83%	$100,664,952.00
NORGES BANK	31 Dec, 2025	5,119,622	5,119,622	0.00%	$84,524,959.00
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	31 Dec, 2025	4,983,726	-481,311	-8.81%	$82,281,317.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	3,731,695	0	0.00%	$61,610,284.00
Capital Research Global Investors	31 Dec, 2025	3,729,244	-1,031,614	-21.67%	$61,569,818.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	3,557,935	37,521	1.07%	$58,741,507.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	3,458,131	-7,926	-0.23%	$57,104,172.00
Holocene Advisors, LP	31 Dec, 2025	3,152,734	17,022	0.54%	$52,051,638.00
Crestline Management, LP	31 Dec, 2025	2,810,732	-600,000	-17.59%	$46,405,185.00
Fisher Asset Management, LLC	31 Dec, 2025	2,589,403	957,907	58.71%	$42,751,042.00
UBS Group AG	31 Dec, 2025	2,404,704	392,351	19.50%	$39,701,663.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	2,374,303	17,089	0.72%	$39,198,394.00
Aberdeen Group plc	31 Dec, 2025	2,032,967	919,381	82.56%	$33,564,285.00

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