Denali Therapeutics Inc. (DNLI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

11,140,145Shares held by institutions

$201,525,223Value of institutional holdings

79.66%Institutional ownership %

1.46%Shares Changed QoQ

230No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Denali Therapeutics Inc. (NASDAQ:DNLI) showed up in the 13F filings of 246 institutional investors as of December 2025.

These investors collectively held 85.8% of Denali Therapeutics's outstanding shares in December 2025, up from 79.6% in September 2025.
They increased total shares held in Denali Therapeutics by 14.59% from last quarter, and the number of investors in DNLI increased 9.82% annually.
During the quarter, 135 of these 246 funds increased positions in DNLI, 69 reduced exposure, and 42 held steady.
Altogether, these fund groups held 148.02Mn shares in DNLI by December 2025, up by 18.84Mn shares quarter on quarter, and up 17.76Mn shares year over year.
As of December 31, 2025, the biggest holder of Denali Therapeutics is VANGUARD GROUP INC at 13.06Mn shares, representing 7.57% of shares outstanding.
Leading buyers of Denali Therapeutics shares for the quarter ending December 2025 were NORGES BANK (5.12Mn), T. Rowe Price Investment Management, Inc. (2.86Mn), Goldman Sachs Group Inc (1.67Mn), Temasek Holdings (Private) Ltd (1.66Mn), Lynx1 Capital Management LP (1.48Mn).
The biggest sellers of Denali Therapeutics for the quarter ending December 2025 included STEMPOINT CAPITAL LP (1.32Mn), Capital Research Global Investors (1.03Mn), Bank Of America Corp /De/ (990.13K), MILLENNIUM MANAGEMENT LLC (937.4K), Point72 Asset Management, L.P. (819.54K).
Per Business Quant, the top 10 investors in DNLI for the quarter ending December 2025 include VANGUARD GROUP INC (13.06Mn), BlackRock, Inc. (12.71Mn), BAILLIE GIFFORD & CO (12.31Mn), T. Rowe Price Investment Management, Inc. (8.5Mn), Temasek Holdings (Private) Ltd (7.01Mn), State Street Corp (6.26Mn), FMR LLC (6.1Mn), NORGES BANK (5.12Mn), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (4.98Mn), Goldman Sachs Group Inc (3.84Mn).

246 Institutional Holders

11,140,145 Total Shares Held

Rows:

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Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	425,575	3.46%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	1,064,972	8.88%	$0.00
T. Rowe Price Investment Management, Inc.	31 Dec, 2025	2,861,559	50.75%	$0.00
Barclays Plc	31 Dec, 2025	-285,525	-41.21%	$0.00
BAILLIE GIFFORD & CO	31 Dec, 2025	719,304	6.21%	$0.00
Holocene Advisors, LP	31 Dec, 2025	17,022	0.54%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	1,447	133.61%	$0.00
Temasek Holdings (Private) Ltd	31 Dec, 2025	1,657,142	30.94%	$0.00
UBS Group AG	31 Dec, 2025	392,351	19.50%	$0.00
State Street Corp	31 Dec, 2025	799,110	14.62%	$0.00
Aberdeen Group plc	31 Dec, 2025	919,381	82.56%	$0.00
FMR LLC	31 Dec, 2025	-243,105	-3.83%	$0.00
Lynx1 Capital Management LP	31 Dec, 2025	1,477,063	564.44%	$0.00
NORGES BANK	31 Dec, 2025	5,119,622	0.00%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	-819,535	-32.53%	$0.00
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	31 Dec, 2025	-481,311	-8.81%	$0.00
Siren, L.L.C.	31 Dec, 2025	575,000	69.99%	$0.00
Goldman Sachs Group Inc	31 Dec, 2025	1,672,098	77.28%	$0.00
Pictet Asset Management Holding SA	31 Dec, 2025	829,946	166.27%	$0.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	0	0.00%	$0.00

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