Denali Therapeutics's three largest insider shareholders as of March 23, 2026 are Robert Nelsen (Director, 9.67Mn shares), Bros. Advisors Lp Baker (Director, 3.42Mn shares), Ryan J. Watts (President And Ceo, 2.15Mn shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Robert Nelsen | 0 | 9,668,749 | 03 Jun, 2021 | |
| Bros. Advisors Lp Baker | 0 | 3,415,958 | 05 Jun, 2025 | |
| Ryan J. Watts | President And Ceo | 0 | 2,152,604 | 05 Sep, 2025 |
| Marc Tessier-Lavigne | 1,886,576 | 0 | 05 Jun, 2025 | |
| Alexander O. Schuth | Cofo And Secretary | 0 | 539,307 | 09 Jan, 2024 |
| Jay T Flatley | 0 | 340,529 | 05 Jun, 2023 | |
| Ryan J. Watts | President And Ceo | 296,833 | 0 | 08 Jan, 2026 |
| Alexander O. Schuth | Cofo And Secretary | 282,828 | 0 | 08 Jan, 2026 |
| Carole Ho | Chief Medical Officer | 216,585 | 0 | 14 Aug, 2025 |
| Carole Ho | Chief Medical Officer | 0 | 198,777 | 09 Jan, 2024 |
| Vicki L Sato | 107,976 | 0 | 03 Jan, 2025 | |
| Marc Tessier-Lavigne | 0 | 78,848 | 30 Dec, 2021 | |
| Steve E. Krognes | 31,794 | 0 | 05 Jun, 2025 | |
| Peter S Klein | 27,533 | 0 | 05 Jun, 2025 | |
| Jennifer E. Cook | 26,075 | 0 | 05 Jun, 2025 | |
| Nancy Thornberry | 24,717 | 0 | 05 Jun, 2025 | |
| Erik Harris | 17,052 | 0 | 04 Jun, 2024 | |
| Jay T Flatley | 16,220 | 0 | 05 Jun, 2025 | |
| David P Schenkein | 15,257 | 0 | 05 Jun, 2025 | |
| Robert Nelsen | 12,432 | 0 | 04 Jun, 2021 | |
| Hauwermeiren Timothy Van | 10,632 | 0 | 06 Nov, 2025 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 06 Jan, 2026 | Alexander O. Schuth | Common Stock | D | 17,218 | $16.50 | 282,828 | D | S |
| 06 Jan, 2026 | Ryan J. Watts | Common Stock | D | 35,198 | $16.50 | 296,833 | D | S |
| 03 Jan, 2026 | Ryan J. Watts | Common Stock | A | 78,960 | $0.00 | 332,031 | D | A |
| 03 Jan, 2026 | Alexander O. Schuth | Common Stock | A | 57,700 | $0.00 | 300,046 | D | A |
| 03 Jan, 2026 | Ryan J. Watts | Stock Option (right to buy) | A | 236,880 | $0.00 | 236,880 | D | A |
| 03 Jan, 2026 | Alexander O. Schuth | Stock Option (right to buy) | A | 173,100 | $0.00 | 173,100 | D | A |
| 11 Dec, 2025 | Bros. Advisors Lp Baker | $0.01 Prefunded Warrants | A | 190,523 | $17.49 | 2,335,469 | I | P |
| 11 Dec, 2025 | Bros. Advisors Lp Baker | $0.01 Prefunded Warrants | A | 2,095,191 | $17.49 | 25,996,310 | I | P |
| 04 Nov, 2025 | Hauwermeiren Timothy Van | Common Stock | A | 10,632 | $0.00 | 10,632 | D | A |
| 04 Nov, 2025 | Hauwermeiren Timothy Van | Stock Option (right to buy) | A | 31,897 | $0.00 | 31,897 | D | A |
| 03 Sep, 2025 | Ryan J. Watts | Common Stock | D | 50,000 | $0.00 | 2,152,604 | I | G |
| 12 Aug, 2025 | Carole Ho | Common Stock | D | 2,937 | $13.58 | 217,391 | D | S |
| 12 Aug, 2025 | Alexander O. Schuth | Common Stock | D | 2,937 | $13.58 | 242,346 | D | S |
| 13 Aug, 2025 | Carole Ho | Common Stock | D | 806 | $14.64 | 216,585 | D | S |
| 05 Aug, 2025 | Carole Ho | Common Stock | A | 44,655 | $0.68 | 220,328 | D | M |
| 05 Aug, 2025 | Carole Ho | Stock Option (right to buy) | D | 44,655 | $0.00 | 62,500 | D | M |
| 09 Jul, 2025 | Ryan J. Watts | Common Stock | A | 455,282 | $0.68 | 708,353 | D | M |
| 09 Jul, 2025 | Ryan J. Watts | Common Stock | A | 40,000 | $5.28 | 748,353 | D | M |
| 09 Jul, 2025 | Ryan J. Watts | Common Stock | D | 495,282 | $15.00 | 253,071 | D | S |
| 09 Jul, 2025 | Ryan J. Watts | Stock Option (right to buy) | D | 455,282 | $0.00 | 622,809 | D | M |