CytomX Therapeutics (CTMX) Operating Margin (2014 - 2026)
CytomX Therapeutics (CTMX) reported Operating Margin of -1677.08% for Q2 2026, down 1670.19 percentage points from -6.89% a year earlier and down 1485.31 percentage points from the prior quarter.
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Analysis
CytomX Therapeutics (CTMX) Operating Margin (2014 - 2026) Analysis & Trends
Over the twelve months ended Jun 30, 2026, CytomX Therapeutics' Operating Margin came in at -476.19%, down 506.76 percentage points year-over-year; for FY2025, it was -29.35%, down 47.45 percentage points from FY2024.
- Operating Margin has a five-year change of +88.35 percentage points (FY2020 to FY2025).
- By year, Operating Margin came in at 18.10% in FY2024 (+24.51 pp), -6.41% in FY2023 (+184.21 pp), -190.61% in FY2022 (+120.39 pp) and -311.00% in FY2021 (-193.30 pp).
- Five-year quarterly Operating Margin spans a low of -4212.97% in Q4 2025 and a high of 46.41% in Q4 2024.
- Year over year, Operating Margin has now declined in each of the last four quarters, with an average year-over-year change of -793.78 percentage points over the last eight quarters.
- The high point for year-over-year Operating Margin in five years was Q1 2023 (a gain of 330.61 percentage points); the low point was Q4 2025 (a drop of 4259.38 percentage points).
- Per Business Quant data, the three quarters before Q2 2026 came in at -191.77% (Q1 2026), -4212.97% (Q4 2025) and -264.43% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 645.01 Bn | 563.54 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 465.23 Bn | 438.39 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 368.40 Bn | 322.83 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 278.02 Bn | 233.89 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 254.57 Bn | 228.13 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 229.02 Bn | 184.42 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 187.74 Bn | 161.85 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.45 Bn | 105.45 Bn | 2.84 Bn | 37.40% |
| 10 | CytomX Therapeutics | 599.22 Mn | -358.44 Mn | - | -1,677.08% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -1,677.08% |
| Mar 31, 2026 | -191.77% |
| Dec 31, 2025 | -4,212.97% |
| Sep 30, 2025 | -264.43% |
| Jun 30, 2025 | -6.89% |
| Mar 31, 2025 | 44.43% |
| Dec 31, 2024 | 46.41% |
| Sep 30, 2024 | 12.30% |
| Jun 30, 2024 | -33.65% |
| Mar 31, 2024 | 28.11% |
| Dec 31, 2023 | -2.28% |
| Sep 30, 2023 | 11.84% |
| Jun 30, 2023 | -13.54% |
| Mar 31, 2023 | -24.06% |
| Dec 31, 2022 | -47.25% |
| Sep 30, 2022 | -266.53% |
| Jun 30, 2022 | -233.83% |
| Mar 31, 2022 | -354.67% |
| Dec 31, 2021 | -313.54% |
| Sep 30, 2021 | -337.78% |
API Access
CytomX Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=CTMX&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "CTMX", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=CTMX&period=max&api_key=YOUR_API_KEY");
const data = await res.json();