Growth Metrics

Apellis Pharmaceuticals (APLS) Operating Margin (2020 - 2025)

Apellis Pharmaceuticals (APLS) has 6 years of Operating Margin data on record, last reported at 25.58% in Q4 2025.

  • For Q4 2025, Operating Margin fell 7146.0% year-over-year to 25.58%; the TTM value through Dec 2025 reached 5.52%, up 1081.0%, while the annual FY2025 figure was 5.52%, 1081.0% up from the prior year.
  • Operating Margin reached 25.58% in Q4 2025 per APLS's latest filing, down from 48.67% in the prior quarter.
  • Across five years, Operating Margin topped out at 481.36% in Q4 2021 and bottomed at 31185.71% in Q2 2021.
  • Average Operating Margin over 5 years is 1945.69%, with a median of 57.74% recorded in 2023.
  • The widest YoY moves for Operating Margin: up 3027514bps in 2022, down -120524bps in 2022.
  • A 5-year view of Operating Margin shows it stood at 481.36% in 2021, then tumbled by -250bps to 723.88% in 2022, then surged by 92bps to 57.74% in 2023, then soared by 179bps to 45.88% in 2024, then crashed by -156bps to 25.58% in 2025.
  • Per Business Quant database, its latest 3 readings for Operating Margin were 25.58% in Q4 2025, 48.67% in Q3 2025, and 18.65% in Q2 2025.