As of May 14, 2026, the three largest insider holders of APLS are Venture Investments Ltd Morningside (TenPercentOwner, 12.81Mn shares), Venture Investments Ltd Morningside (TenPercentOwner, 12.81Mn shares), Venture Investments Ltd Morningside (TenPercentOwner, 12.81Mn shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Venture Investments Ltd Morningside | - | 12,806,342 | 0 | 18 Nov, 2021 |
| Venture Investments Ltd Morningside | - | 12,806,342 | 0 | 18 Nov, 2021 |
| Venture Investments Ltd Morningside | - | 12,806,342 | 0 | 18 Nov, 2021 |
| Pascal Deschatelets | Chief Scientific Officer | 1,177,222 | 0 | 30 Jan, 2026 |
| Pascal Deschatelets | Chief Scientific Officer | 1,177,222 | 0 | 30 Jan, 2026 |
| Pascal Deschatelets | Chief Scientific Officer | 1,177,222 | 0 | 30 Jan, 2026 |
| Cedric Francois | Chief Executive Officer | 425,968 | 372,815 | 13 Mar, 2026 |
| Cedric Francois | Chief Executive Officer | 425,968 | 372,815 | 13 Mar, 2026 |
| Cedric Francois | Chief Executive Officer | 425,968 | 372,815 | 13 Mar, 2026 |
| Cedric Francois | Chief Executive Officer | 0 | 472,065 | 01 Nov, 2024 |
| Cedric Francois | Chief Executive Officer | 0 | 472,065 | 01 Nov, 2024 |
| Cedric Francois | Chief Executive Officer | 0 | 472,065 | 01 Nov, 2024 |
| Alec Machiels | - | 384,989 | 0 | 05 Jan, 2026 |
| Alec Machiels | - | 384,989 | 0 | 05 Jan, 2026 |
| Alec Machiels | - | 384,989 | 0 | 05 Jan, 2026 |
| Timothy Eugene Sullivan | Chief Financial Officer | 140,945 | 71,492 | 20 Apr, 2026 |
| A. Sinclair Dunlop | - | 161,567 | 0 | 05 Jan, 2026 |
| A. Sinclair Dunlop | - | 161,567 | 0 | 05 Jan, 2026 |
| A. Sinclair Dunlop | - | 161,567 | 0 | 05 Jan, 2026 |
| David O. Watson | General Counsel | 144,517 | 0 | 30 Jan, 2026 |
| David O. Watson | General Counsel | 144,517 | 0 | 30 Jan, 2026 |
| David O. Watson | General Counsel | 144,517 | 0 | 30 Jan, 2026 |
| Kelley Boucher | Chief People Officer | 127,804 | 0 | 30 Jan, 2026 |
| Kelley Boucher | Chief People Officer | 127,804 | 0 | 30 Jan, 2026 |
| Kelley Boucher | Chief People Officer | 127,804 | 0 | 30 Jan, 2026 |
| Nur Nicholson | Chief Technical Officer | 116,338 | 0 | 30 Jan, 2026 |
| Nur Nicholson | Chief Technical Officer | 116,338 | 0 | 30 Jan, 2026 |
| Nur Nicholson | Chief Technical Officer | 116,338 | 0 | 30 Jan, 2026 |
| Mark Jeffrey Delong | Chief Business Strat Officer | 114,591 | 0 | 13 Feb, 2026 |
| Mark Jeffrey Delong | Chief Business Strat Officer | 114,591 | 0 | 13 Feb, 2026 |
| Mark Jeffrey Delong | Chief Business Strat Officer | 114,591 | 0 | 13 Feb, 2026 |
| Leslie Meltzer | Chief Research And Development | 107,024 | 0 | 30 Jan, 2026 |
| Leslie Meltzer | Chief Research And Development | 107,024 | 0 | 30 Jan, 2026 |
| Leslie Meltzer | Chief Research And Development | 107,024 | 0 | 30 Jan, 2026 |
| Federico Grossi | Chief Medical Officer | 94,884 | 0 | 09 Jan, 2023 |
| Federico Grossi | Chief Medical Officer | 94,884 | 0 | 09 Jan, 2023 |
| Federico Grossi | Chief Medical Officer | 94,884 | 0 | 09 Jan, 2023 |
| Caroline Baumal | Chief Medical Officer | 86,527 | 0 | 23 Jan, 2026 |
| Caroline Baumal | Chief Medical Officer | 86,527 | 0 | 23 Jan, 2026 |
| Caroline Baumal | Chief Medical Officer | 86,527 | 0 | 23 Jan, 2026 |
| Adam J. Townsend | Chief Commercial Officer | 84,050 | 0 | 30 Jan, 2025 |
| Adam J. Townsend | Chief Commercial Officer | 84,050 | 0 | 30 Jan, 2025 |
| Adam J. Townsend | Chief Commercial Officer | 84,050 | 0 | 30 Jan, 2025 |
| Karen Lewis | Chief People Officer | 70,251 | 0 | 30 Jan, 2025 |
| Karen Lewis | Chief People Officer | 70,251 | 0 | 30 Jan, 2025 |
| Karen Lewis | Chief People Officer | 70,251 | 0 | 30 Jan, 2025 |
| Lukas Scheibler | Chief Research Officer | 68,299 | 0 | 05 Dec, 2023 |
| Lukas Scheibler | Chief Research Officer | 68,299 | 0 | 05 Dec, 2023 |
| Lukas Scheibler | Chief Research Officer | 68,299 | 0 | 05 Dec, 2023 |
| James George Chopas | Vp/Chief Accounting Officer | 65,955 | 0 | 30 Jan, 2026 |
| James George Chopas | Vp/Chief Accounting Officer | 65,955 | 0 | 30 Jan, 2026 |
| James George Chopas | Vp/Chief Accounting Officer | 65,955 | 0 | 30 Jan, 2026 |
| Timothy Eugene Sullivan | Chief Financial Officer | 0 | 60,396 | 10 Sep, 2025 |
| Jeffrey Eisele | Chief Development Officer | 55,312 | 0 | 30 Jan, 2025 |
| Jeffrey Eisele | Chief Development Officer | 55,312 | 0 | 30 Jan, 2025 |
| Jeffrey Eisele | Chief Development Officer | 55,312 | 0 | 30 Jan, 2025 |
| David O. Watson | General Counsel | 0 | 50,136 | 12 Sep, 2025 |
| David O. Watson | General Counsel | 0 | 50,136 | 12 Sep, 2025 |
| David O. Watson | General Counsel | 0 | 50,136 | 12 Sep, 2025 |
| Paul R. Fonteyne | - | 30,666 | 0 | 05 Jan, 2026 |
| A. Sinclair Dunlop | - | 0 | 30,142 | 02 Oct, 2025 |
| A. Sinclair Dunlop | - | 0 | 30,142 | 02 Oct, 2025 |
| A. Sinclair Dunlop | - | 0 | 30,142 | 02 Oct, 2025 |
| Gerald Chan | - | 25,666 | 0 | 05 Jan, 2026 |
| Stephanie Monaghan O'Brien | - | 25,666 | 0 | 05 Jan, 2026 |
| Gerald Chan | - | 25,666 | 0 | 05 Jan, 2026 |
| Gerald Chan | - | 25,666 | 0 | 05 Jan, 2026 |
| Craig A Wheeler | - | 24,444 | 0 | 05 Jan, 2026 |
| Craig A Wheeler | - | 24,444 | 0 | 05 Jan, 2026 |
| Craig A Wheeler | - | 24,444 | 0 | 05 Jan, 2026 |
| Victoria L. Brown | Program Team Lead | 23,556 | 0 | 24 Jan, 2023 |
| Victoria L. Brown | Program Team Lead | 23,556 | 0 | 24 Jan, 2023 |
| Victoria L. Brown | Program Team Lead | 23,556 | 0 | 24 Jan, 2023 |
| Keli Walbert | - | 17,051 | 0 | 05 Jan, 2026 |
| Keli Walbert | - | 17,051 | 0 | 05 Jan, 2026 |
| Keli Walbert | - | 17,051 | 0 | 05 Jan, 2026 |
| David O. Watson | General Counsel | 0 | 10,000 | 06 Mar, 2025 |
| David O. Watson | General Counsel | 0 | 10,000 | 06 Mar, 2025 |
| David O. Watson | General Counsel | 0 | 10,000 | 06 Mar, 2025 |
| Stephanie Monaghan O'Brien | - | 0 | 5,750 | 08 Apr, 2026 |
| Nicole D Perry | Vice President Accounting | 4,847 | 0 | 03 Aug, 2021 |
| Nicole D Perry | Vice President Accounting | 4,847 | 0 | 03 Aug, 2021 |
| Nicole D Perry | Vice President Accounting | 4,847 | 0 | 03 Aug, 2021 |
| A. Sinclair Dunlop | - | 0 | 1,341 | 29 Jun, 2022 |
| A. Sinclair Dunlop | - | 0 | 1,341 | 29 Jun, 2022 |
| A. Sinclair Dunlop | - | 0 | 1,341 | 29 Jun, 2022 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 17 Apr, 2026 | Timothy Eugene Sullivan | Common Stock | D | 11,096 | $0.00 | 140,945 | D | G |
| 17 Apr, 2026 | Timothy Eugene Sullivan | Common Stock | A | 11,096 | $0.00 | 71,492 | I | G |
| 06 Apr, 2026 | Stephanie Monaghan O'Brien | Common Stock | A | 5,750 | $0.00 | 5,750 | I | J |
| 11 Mar, 2026 | Cedric Francois | Common Stock | D | 64,869 | $0.00 | 425,968 | D | G |
| 11 Mar, 2026 | Cedric Francois | Common Stock | D | 64,869 | $0.00 | 425,968 | D | G |
| 11 Mar, 2026 | Cedric Francois | Common Stock | D | 64,869 | $0.00 | 425,968 | D | G |
| 11 Mar, 2026 | Cedric Francois | Common Stock | A | 64,869 | $0.00 | 372,815 | I | G |
| 11 Mar, 2026 | Cedric Francois | Common Stock | A | 64,869 | $0.00 | 372,815 | I | G |
| 11 Mar, 2026 | Cedric Francois | Common Stock | A | 64,869 | $0.00 | 372,815 | I | G |
| 27 Feb, 2026 | Mikael Dolsten | Common Stock | A | 14,312 | $0.00 | 14,312 | D | A |
| 27 Feb, 2026 | Mikael Dolsten | Stock Option (Right to Buy) | A | 24,135 | $20.96 | 24,135 | D | A |
| 11 Feb, 2026 | Mark Jeffrey Delong | Common Stock | D | 368 | $22.15 | 114,591 | D | S |
| 11 Feb, 2026 | Mark Jeffrey Delong | Common Stock | D | 368 | $22.15 | 114,591 | D | S |
| 11 Feb, 2026 | Mark Jeffrey Delong | Common Stock | D | 368 | $22.15 | 114,591 | D | S |
| 03 Feb, 2026 | Cedric Francois | Common Stock | A | 8,840 | $3.76 | 490,837 | D | M |
| 03 Feb, 2026 | Cedric Francois | Common Stock | A | 8,840 | $3.76 | 490,837 | D | M |
| 03 Feb, 2026 | Cedric Francois | Common Stock | A | 8,840 | $3.76 | 490,837 | D | M |
| 03 Feb, 2026 | Cedric Francois | Stock Option (Right to Buy) | D | 8,840 | $0.00 | 0 | D | M |
| 03 Feb, 2026 | Cedric Francois | Stock Option (Right to Buy) | D | 8,840 | $0.00 | 0 | D | M |
| 03 Feb, 2026 | Cedric Francois | Stock Option (Right to Buy) | D | 8,840 | $0.00 | 0 | D | M |