Apellis Pharmaceuticals, Inc. (APLS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

130,067,000Shares Outstanding

138,911,905Shares held by institutions

$5,678,718,676Value of institutional holdings

106.80%Institutional ownership %

17.50%Shares Changed QoQ

272No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Apellis Pharmaceuticals, Inc. (NASDAQ:APLS) appears in 272 institutional 13F filings for the quarter ending December 2025.

These investors held 97.3% of outstanding shares in December 2025, up from 95.7% in September 2025.
They increased total shares held in APLS by 7.48% quarter over quarter, and investors in Apellis Pharmaceuticals increased 7.09% from a year ago.
Activity in APLS broke down as 150 buyers, 96 sellers, and 26 unchanged among 272 total holders.
Altogether, these fund groups held 126.5Mn shares in APLS by December 2025, up by 8.81Mn shares quarter on quarter, and down 13.29Mn shares year over year.
Avoro Capital Advisors LLC leads ownership in APLS with 24.44Mn shares as of December 31, 2025, equal to 18.79% of outstanding shares.
The biggest buyers of Apellis Pharmaceuticals for the quarter ending December 2025 included Avoro Capital Advisors LLC (12.22Mn), RTW INVESTMENTS, LP (7.67Mn), WELLINGTON MANAGEMENT GROUP LLP (3.43Mn), SUVRETTA CAPITAL MANAGEMENT, LLC (1.26Mn), NORGES BANK (1.2Mn).
Leading sellers of Apellis Pharmaceuticals shares for the quarter ending December 2025 were JENNISON ASSOCIATES LLC (2.84Mn), AQR CAPITAL MANAGEMENT LLC (2.21Mn), Bank Of America Corp /De/ (2.0Mn), Amundi (1.46Mn), Ing Groep Nv (1.04Mn).
Apellis Pharmaceuticals's 10 largest shareholders as of December 2025 include Avoro Capital Advisors LLC (24.44Mn), WELLINGTON MANAGEMENT GROUP LLP (12.72Mn), VANGUARD GROUP INC (10.67Mn), Morgan Stanley (9.17Mn), Deep Track Capital, LP (7.75Mn), RTW INVESTMENTS, LP (7.67Mn), BlackRock, Inc. (6.26Mn), State Street Corp (4.61Mn), UBS Group AG (4.19Mn), SUVRETTA CAPITAL MANAGEMENT, LLC (4.14Mn) per Business Quant data.

272 Institutional Holders

138,911,905 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Avoro Capital Advisors LLC	31 Dec, 2025	24,444,444	12,222,222	100.00%	$614,044,434.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	12,721,352	3,430,392	36.92%	$319,560,362.00
VANGUARD GROUP INC	31 Dec, 2025	10,674,865	687,471	6.88%	$268,152,609.00
Morgan Stanley	31 Dec, 2025	9,173,004	-470,244	-4.88%	$230,425,882.00
Deep Track Capital, LP	31 Dec, 2025	7,750,000	-250,382	-3.13%	$194,680,000.00
RTW INVESTMENTS, LP	31 Dec, 2025	7,666,764	7,666,764	0.00%	$192,589,112.00
BlackRock, Inc.	31 Dec, 2025	6,260,113	-8,352	-0.13%	$157,254,037.00
State Street Corp	31 Dec, 2025	4,613,446	575,802	14.26%	$115,889,764.00
UBS Group AG	31 Dec, 2025	4,186,222	756,317	22.05%	$105,157,897.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	4,139,426	1,261,426	43.83%	$103,982,381.00
Polar Capital Holdings Plc	31 Dec, 2025	3,706,510	1,056,280	39.86%	$93,107,531.00
Siren, L.L.C.	31 Dec, 2025	2,578,396	0	0.00%	$64,769,308.00
ORBIMED ADVISORS LLC	31 Dec, 2025	2,429,868	106,500	4.58%	$61,038,284.00
AQR CAPITAL MANAGEMENT LLC	31 Dec, 2025	2,276,687	-2,210,667	-49.26%	$57,190,378.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,025,669	-47,244	-2.28%	$50,896,177.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	1,504,299	-2,843,756	-65.40%	$37,787,991.00
DEUTSCHE BANK AG\	31 Dec, 2025	1,385,263	-119,194	-7.92%	$34,797,807.00
NORGES BANK	31 Dec, 2025	1,198,444	1,198,444	0.00%	$30,104,913.00
Hudson Bay Capital Management LP	31 Dec, 2025	1,179,828	342,828	40.96%	$29,637,279.00
Bank Of Nova Scotia	31 Dec, 2025	1,070,141	-386,084	-26.51%	$26,881,945.00

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