Amylyx Pharmaceuticals (AMLX) Operating Expenses (2021 - 2026)

Amylyx Pharmaceuticals' (AMLX) quarterly Operating Expenses came in at $43.8 million in Q1 2026, up 15.81% year-on-year from $37.8 million in Q1 2025, and up 19.6% quarter-over-quarter from $36.6 million in Q4 2025.

Amylyx Pharmaceuticals (AMLX) Operating Expenses (2021 - 2026) Analysis & Trends

Amylyx Pharmaceuticals' Operating Expenses history runs 6 years deep, the most recent figure standing at $43.8 million for Q1 2026.

  • On a quarterly basis, Operating Expenses rose 15.81% year-over-year to $43.8 million in Q1 2026; TTM through Mar 2026 was $159.3 million, a 30.49% decrease from a year earlier, with the FY2025 full-year figure at $153.3 million, down 61.88% from the prior year.
  • Operating Expenses improved to $43.8 million in Q1 2026 per AMLX's latest filing, from $36.6 million in the prior quarter.
  • Across five years, Operating Expenses topped out at $210.8 million in Q1 2024 and bottomed at $36.0 million in Q3 2025.
  • The 5-year median for Operating Expenses is $55.0 million (2022), against an average of $68.5 million.
  • Across the five-year window, Operating Expenses soared 271.57% in 2022 and sank 82.06% in 2025, its largest moves.
  • Year by year, Operating Expenses stood at $66.5 million in 2022, then jumped by 60.23% to $106.5 million in 2023, then plunged by 62.46% to $40.0 million in 2024, then decreased by 8.46% to $36.6 million in 2025, then grew by 19.6% to $43.8 million in 2026.
  • Per Business Quant, the three latest AMLX Operating Expenses figures stand at $43.8 million (Q1 2026), $36.6 million (Q4 2025), and $36.0 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Haleon 87.22 Bn 85.35 Bn - -
2 Teva Pharmaceutical Industries 39.60 Bn 35.87 Bn 1.97 Bn 1.00 Bn
3 Zoetis 31.46 Bn 29.52 Bn 1.62 Bn 788.00 Mn
4 Takeda Pharmaceutical 26.49 Bn 22.44 Bn 4.39 Bn 12.58 Bn
5 United Therapeutics 23.03 Bn 20.88 Bn 648.10 Mn 455.70 Mn
6 Universe Pharmaceuticals 23.03 Bn -10.56 Bn - -
7 Viatris 20.90 Bn 19.09 Bn 1.16 Bn 1.24 Bn
8 Neurocrine Biosciences 17.50 Bn 16.19 Bn 800.70 Mn 621.10 Mn
9 Elanco Animal Health 12.33 Bn 11.91 Bn 785.00 Mn 494.00 Mn
10 Amylyx Pharmaceuticals 1.94 Bn 1.94 Bn - 43.78 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 43.78 Mn
Dec 31, 2025 36.61 Mn
Sep 30, 2025 36.03 Mn
Jun 30, 2025 42.86 Mn
Mar 31, 2025 37.80 Mn
Dec 31, 2024 39.99 Mn
Sep 30, 2024 76.08 Mn
Jun 30, 2024 75.26 Mn
Mar 31, 2024 210.77 Mn
Dec 31, 2023 106.52 Mn
Sep 30, 2023 83.97 Mn
Jun 30, 2023 78.02 Mn
Mar 31, 2023 73.48 Mn
Dec 31, 2022 66.48 Mn
Sep 30, 2022 55.03 Mn
Jun 30, 2022 54.25 Mn
Mar 31, 2022 47.81 Mn
Dec 31, 2021 28.32 Mn
Sep 30, 2021 23.20 Mn
Jun 30, 2021 18.59 Mn