Alnylam Pharmaceuticals (ALNY) Operating Expenses (2009 - 2026)

Alnylam Pharmaceuticals (ALNY) reported Operating Expenses of $898.5 million for Q1 2026, up 55.97% on a YoY basis from $576.1 million in Q1 2025, and down 6.92% quarter-over-quarter from $965.3 million in Q4 2025.

Alnylam Pharmaceuticals (ALNY) Operating Expenses (2009 - 2026) Analysis & Trends

Alnylam Pharmaceuticals has reported Operating Expenses for 18 years, with the latest figure at $898.5 million in Q1 2026.

  • For the quarter ending Q1 2026, Operating Expenses rose 55.97% year-over-year to $898.5 million; the trailing twelve-month figure through Mar 2026 stood at $3.5 billion (up 43.49% YoY), and the FY2025 full-year result was $3.2 billion, up 32.46% from the prior year.
  • Operating Expenses for Q1 2026 stood at $898.5 million, down from $965.3 million in the prior quarter.
  • The five-year high for Operating Expenses was $965.3 million in Q4 2025, with the low at $360.0 million in Q1 2022.
  • Historically, Operating Expenses has averaged $615.8 million across 5 years, with a median of $556.1 million in 2023.
  • Annual changes were most pronounced in 2022 — Operating Expenses dropped 1.05% — and 2026, when it surged 55.97%.
  • Alnylam Pharmaceuticals' Operating Expenses stood at $523.6 million in 2022, then grew by 6.2% to $556.1 million in 2023, then rose by 25.57% to $698.3 million in 2024, then jumped by 38.23% to $965.3 million in 2025, then decreased by 6.92% to $898.5 million in 2026.
  • The last three Operating Expenses figures came in at $898.5 million (Q1 2026), $965.3 million (Q4 2025), and $881.0 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 Alnylam Pharmaceuticals 37.04 Bn 34.03 Bn 959.66 Mn 898.54 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 898.54 Mn
Dec 31, 2025 965.32 Mn
Sep 30, 2025 881.04 Mn
Jun 30, 2025 789.89 Mn
Mar 31, 2025 576.11 Mn
Dec 31, 2024 698.33 Mn
Sep 30, 2024 577.82 Mn
Jun 30, 2024 611.21 Mn
Mar 31, 2024 537.77 Mn
Dec 31, 2023 556.12 Mn
Sep 30, 2023 536.66 Mn
Jun 30, 2023 548.59 Mn
Mar 31, 2023 469.10 Mn
Dec 31, 2022 523.65 Mn
Sep 30, 2022 522.35 Mn
Jun 30, 2022 416.50 Mn
Mar 31, 2022 359.99 Mn
Dec 31, 2021 453.10 Mn
Sep 30, 2021 369.31 Mn
Jun 30, 2021 366.71 Mn