Zymeworks (ZYME) Operating Expenses (2021 - 2026)
Zymeworks' (ZYME) quarterly Operating Expenses came in at $49.5 million in Q1 2026, down 6.06% year-on-year from $52.7 million in Q1 2025, and up 6.13% quarter-over-quarter from $46.7 million in Q4 2025.
Zymeworks (ZYME) Operating Expenses (2021 - 2026) Analysis & Trends
Zymeworks has disclosed Operating Expenses across 6 years of filings, most recently posting $49.5 million for Q1 2026.
- Operating Expenses for Q1 2026 came in at $49.5 million, down 6.06% year-over-year; the trailing twelve-month figure through Mar 2026 was $195.3 million (down 10.53% YoY), and the FY2025 annual result was $198.5 million, down 6.98% from the prior year.
- Operating Expenses came in at $49.5 million for Q1 2026 at Zymeworks, up from $46.7 million in the prior quarter.
- In the past five years, Operating Expenses ranged from a high of $83.1 million in Q4 2022 to a low of $40.3 million in Q4 2023.
- The 5-year median for Operating Expenses is $52.7 million (2025), against an average of $56.3 million.
- Across the five-year window, Operating Expenses soared 36.86% in 2022 and slumped 51.45% in 2023, its largest moves.
- Zymeworks' Operating Expenses stood at $83.1 million in 2022, then plunged by 51.45% to $40.3 million in 2023, then surged by 31.98% to $53.2 million in 2024, then dropped by 12.36% to $46.7 million in 2025, then rose by 6.13% to $49.5 million in 2026.
- The last three Operating Expenses figures came in at $49.5 million (Q1 2026), $46.7 million (Q4 2025), and $49.7 million (Q3 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | 4.33 Mn |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | 32.68 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 2.97 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -138.30 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | 15.76 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | 574,669.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.85 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -67.40 Mn |
| 10 | Zymeworks | 1.73 Bn | 1.36 Bn | - | 49.53 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 49.53 Mn |
| Dec 31, 2025 | 46.67 Mn |
| Sep 30, 2025 | 49.72 Mn |
| Jun 30, 2025 | 49.40 Mn |
| Mar 31, 2025 | 52.72 Mn |
| Dec 31, 2024 | 53.25 Mn |
| Sep 30, 2024 | 50.21 Mn |
| Jun 30, 2024 | 62.13 Mn |
| Mar 31, 2024 | 47.83 Mn |
| Dec 31, 2023 | 40.35 Mn |
| Sep 30, 2023 | 49.74 Mn |
| Jun 30, 2023 | 61.12 Mn |
| Mar 31, 2023 | 62.86 Mn |
| Dec 31, 2022 | 83.10 Mn |
| Sep 30, 2022 | 52.99 Mn |
| Jun 30, 2022 | 71.27 Mn |
| Mar 31, 2022 | 74.60 Mn |
| Dec 31, 2021 | 60.72 Mn |
| Sep 30, 2021 | 65.36 Mn |