Zymeworks (ZYME) Operating Expenses (2021 - 2026)

Zymeworks' (ZYME) quarterly Operating Expenses came in at $49.5 million in Q1 2026, down 6.06% year-on-year from $52.7 million in Q1 2025, and up 6.13% quarter-over-quarter from $46.7 million in Q4 2025.

Zymeworks (ZYME) Operating Expenses (2021 - 2026) Analysis & Trends

Zymeworks has disclosed Operating Expenses across 6 years of filings, most recently posting $49.5 million for Q1 2026.

  • Operating Expenses for Q1 2026 came in at $49.5 million, down 6.06% year-over-year; the trailing twelve-month figure through Mar 2026 was $195.3 million (down 10.53% YoY), and the FY2025 annual result was $198.5 million, down 6.98% from the prior year.
  • Operating Expenses came in at $49.5 million for Q1 2026 at Zymeworks, up from $46.7 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $83.1 million in Q4 2022 to a low of $40.3 million in Q4 2023.
  • The 5-year median for Operating Expenses is $52.7 million (2025), against an average of $56.3 million.
  • Across the five-year window, Operating Expenses soared 36.86% in 2022 and slumped 51.45% in 2023, its largest moves.
  • Zymeworks' Operating Expenses stood at $83.1 million in 2022, then plunged by 51.45% to $40.3 million in 2023, then surged by 31.98% to $53.2 million in 2024, then dropped by 12.36% to $46.7 million in 2025, then rose by 6.13% to $49.5 million in 2026.
  • The last three Operating Expenses figures came in at $49.5 million (Q1 2026), $46.7 million (Q4 2025), and $49.7 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 Zymeworks 1.73 Bn 1.36 Bn - 49.53 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 49.53 Mn
Dec 31, 2025 46.67 Mn
Sep 30, 2025 49.72 Mn
Jun 30, 2025 49.40 Mn
Mar 31, 2025 52.72 Mn
Dec 31, 2024 53.25 Mn
Sep 30, 2024 50.21 Mn
Jun 30, 2024 62.13 Mn
Mar 31, 2024 47.83 Mn
Dec 31, 2023 40.35 Mn
Sep 30, 2023 49.74 Mn
Jun 30, 2023 61.12 Mn
Mar 31, 2023 62.86 Mn
Dec 31, 2022 83.10 Mn
Sep 30, 2022 52.99 Mn
Jun 30, 2022 71.27 Mn
Mar 31, 2022 74.60 Mn
Dec 31, 2021 60.72 Mn
Sep 30, 2021 65.36 Mn