Growth Metrics

Zymeworks (ZYME) Operating Expenses (2021 - 2026)

Zymeworks recorded quarterly Operating Expenses of $49.5 million in Q1 2026, up 6.13% quarter-over-quarter from $46.7 million in Q4 2025, and down 6.06% year-over-year from $52.7 million in Q1 2025.

Zymeworks' Operating Expenses history runs 6 years deep, the most recent figure standing at $49.5 million for Q1 2026.

  • In Q1 2026, Operating Expenses fell 6.06% year-over-year to $49.5 million; the TTM figure through Mar 2026 stood at $195.3 million (down 10.53% YoY), while the FY2025 annual figure was $198.5 million, down 6.98% from the prior year.
  • Operating Expenses came in at $49.5 million for Q1 2026 at Zymeworks, up from $46.7 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $83.1 million in Q4 2022 to a low of $40.3 million in Q4 2023.
  • A 5-year average of $56.3 million and a median of $52.7 million in 2025 frame the typical range for Operating Expenses.
  • Across the five-year window, Operating Expenses jumped 36.86% in 2022 and sank 51.45% in 2023, its largest moves.
  • Zymeworks' Operating Expenses stood at $83.1 million in 2022, then tumbled by 51.45% to $40.3 million in 2023, then soared by 31.98% to $53.2 million in 2024, then declined by 12.36% to $46.7 million in 2025, then gained by 6.13% to $49.5 million in 2026.
  • According to Business Quant data, Operating Expenses over the past three periods registered $49.5 million, $46.7 million, and $49.7 million for Q1 2026, Q4 2025, and Q3 2025 respectively.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.97 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - 4.33 Mn
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -138.30 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 15.76 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.85 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 2.96 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 898.54 Mn
10 Zymeworks 1.84 Bn 1.47 Bn - 49.53 Mn

Historic Data

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DateValue
Mar 31, 2026 49.53 Mn
Dec 31, 2025 46.67 Mn
Sep 30, 2025 49.72 Mn
Jun 30, 2025 49.40 Mn
Mar 31, 2025 52.72 Mn
Dec 31, 2024 53.25 Mn
Sep 30, 2024 50.21 Mn
Jun 30, 2024 62.13 Mn
Mar 31, 2024 47.83 Mn
Dec 31, 2023 40.35 Mn
Sep 30, 2023 49.74 Mn
Jun 30, 2023 61.12 Mn
Mar 31, 2023 62.86 Mn
Dec 31, 2022 83.10 Mn
Sep 30, 2022 52.99 Mn
Jun 30, 2022 71.27 Mn
Mar 31, 2022 74.60 Mn
Dec 31, 2021 60.72 Mn
Sep 30, 2021 65.36 Mn