NuCana (NCNA) Return on Capital Employed (2018 - 2025)

NuCana's (NCNA) quarterly Return on Capital Employed came in at 68.47% in Q4 2025, up 19453.0% year-on-year from N/an in Q4 2024, and up 23.19% quarter-over-quarter from 89.13% in Q3 2025.

NuCana (NCNA) Return on Capital Employed (2018 - 2025) Analysis & Trends

NuCana has disclosed Return on Capital Employed across 8 years of filings, most recently posting 68.47% for Q4 2025.

  • Return on Capital Employed for Q4 2025 came in at 68.47%, up 19453.0% year-over-year; the trailing twelve-month figure through Dec 2025 was 68.47% (up 19453.0% YoY), and the FY2025 annual result was 116.34%, up 6983.0% from the prior year.
  • Return on Capital Employed came in at 68.47% for Q4 2025 at NuCana, up from 89.13% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 43.6% in Q1 2021 to a low of 672.27% in Q3 2024.
  • The 5-year median for Return on Capital Employed is 98.15% (2022), against an average of 184.79%.
  • Across the five-year window, Return on Capital Employed slumped 51823 bps in 2024 and jumped 58314 bps in 2025, its largest moves.
  • NuCana's Return on Capital Employed stood at 66.9% in 2021, then tumbled by 38 bps to 92.63% in 2022, then sank by 91 bps to 176.79% in 2023, then sank by 49 bps to 263.0% in 2024, then jumped by 74 bps to 68.47% in 2025.
  • The last three Return on Capital Employed figures came in at 68.47% (Q4 2025), 89.13% (Q3 2025), and 420.12% (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - -
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - -
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - 450.31%
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn 51.73%
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - -107.40%
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -
7 Psyence Biomedical 241.78 Bn 241.78 Bn - -
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 21.10%
9 Abivax 94.26 Bn 94.26 Bn - -50.43%
10 NuCana 29.13 Bn 29.13 Bn - -68.47%

Historic Data

Download Data
DateValue
Dec 31, 2025 -68.47%
Sep 30, 2025 -89.13%
Jun 30, 2025 -420.12%
Mar 31, 2025 -291.42%
Dec 31, 2024 -263.00%
Sep 30, 2024 -672.27%
Jun 30, 2024 -526.42%
Mar 31, 2024 -273.36%
Dec 31, 2023 -176.79%
Sep 30, 2023 -154.04%
Jun 30, 2023 -120.77%
Mar 31, 2023 -103.68%
Dec 31, 2022 -92.63%
Sep 30, 2022 -76.52%
Jun 30, 2022 -72.43%
Mar 31, 2022 -76.76%
Dec 31, 2021 -66.90%
Sep 30, 2021 -57.41%
Jun 30, 2021 -50.10%
Mar 31, 2021 -43.60%