Vertex Pharmaceuticals (VRTX) Change in Cash (2009 - 2026)

Vertex Pharmaceuticals (VRTX) recorded quarterly Change in Cash of $417.1 million in Q1 2026, up 197.93% quarter-over-quarter from $140.0 million in Q4 2025, and up 268.46% on a YoY basis from $113.2 million in Q1 2025.

Vertex Pharmaceuticals (VRTX) Change in Cash (2009 - 2026) Analysis & Trends

Vertex Pharmaceuticals' Change in Cash history runs 18 years deep, the most recent figure standing at $417.1 million for Q1 2026.

  • In Q1 2026, Change in Cash rose 268.46% year-over-year to $417.1 million; the TTM figure through Mar 2026 stood at $819.5 million (up 118.28% YoY), while the FY2025 annual figure was $515.6 million, up 108.89% from the prior year.
  • Change in Cash was $417.1 million for Q1 2026 at Vertex Pharmaceuticals, up from $140.0 million in the prior quarter.
  • In the past five years, Change in Cash ranged from a high of $1.3 billion in Q4 2022 to a low of -$4.6 billion in Q2 2024.
  • Historically, Change in Cash has averaged -$76.2 million across 5 years, with a median of $296.6 million in 2025.
  • The sharpest annual moves came in 2022 and 2024: Change in Cash surged 554.96% in 2022, then sank 633.74% in 2024.
  • A 5-year view of Change in Cash shows it stood at $1.3 billion in 2022, then slumped by 155.75% to -$744.3 million in 2023, then advanced by 9.19% to -$675.9 million in 2024, then surged by 120.71% to $140.0 million in 2025, then soared by 197.93% to $417.1 million in 2026.
  • The last three Change in Cash figures came in at $417.1 million (Q1 2026), $140.0 million (Q4 2025), and -$34.2 million (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.44 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 623.00 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 417.10 Mn
9 Abivax 91.96 Bn 91.96 Bn - -45.97 Mn
10 Regeneron Pharmaceuticals 63.43 Bn 54.67 Bn 3.31 Bn -153.10 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 417.10 Mn
Dec 31, 2025 140.00 Mn
Sep 30, 2025 -34.20 Mn
Jun 30, 2025 296.60 Mn
Mar 31, 2025 113.20 Mn
Dec 31, 2024 -675.90 Mn
Sep 30, 2024 657.10 Mn
Jun 30, 2024 -4.58 Bn
Mar 31, 2024 -1.20 Bn
Dec 31, 2023 -744.30 Mn
Sep 30, 2023 963.20 Mn
Jun 30, 2023 857.80 Mn
Mar 31, 2023 -1.22 Bn
Dec 31, 2022 1.34 Bn
Sep 30, 2022 472.90 Mn
Jun 30, 2022 1.10 Bn
Mar 31, 2022 803.90 Mn
Dec 31, 2021 519.90 Mn
Sep 30, 2021 209.10 Mn
Jun 30, 2021 -241.80 Mn