Vertex Pharmaceuticals (VRTX) Change in Cash (2009 - 2026)

Vertex Pharmaceuticals' (VRTX) quarterly Change in Cash came in at $417.1 million in Q1 2026, up 268.46% year-on-year from $113.2 million in Q1 2025, and up 197.93% quarter-over-quarter from $140.0 million in Q4 2025.

Vertex Pharmaceuticals (VRTX) Change in Cash (2009 - 2026) Analysis & Trends

Vertex Pharmaceuticals' Change in Cash history runs 18 years deep, the most recent figure standing at $417.1 million for Q1 2026.

  • On a quarterly basis, Change in Cash rose 268.46% year-over-year to $417.1 million in Q1 2026; TTM through Mar 2026 was $819.5 million, a 118.28% increase from a year earlier, with the FY2025 full-year figure at $515.6 million, up 108.89% from the prior year.
  • Change in Cash rose to $417.1 million in Q1 2026 per VRTX's latest filing, from $140.0 million in the prior quarter.
  • Across five years, Change in Cash topped out at $1.3 billion in Q4 2022 and bottomed at -$4.6 billion in Q2 2024.
  • The 5-year median for Change in Cash is $296.6 million (2025), against an average of -$76.2 million.
  • Across the five-year window, Change in Cash jumped 554.96% in 2022 and sank 633.74% in 2024, its largest moves.
  • Year by year, Change in Cash stood at $1.3 billion in 2022, then plunged by 155.75% to -$744.3 million in 2023, then advanced by 9.19% to -$675.9 million in 2024, then surged by 120.71% to $140.0 million in 2025, then soared by 197.93% to $417.1 million in 2026.
  • Per Business Quant, the three latest VRTX Change in Cash figures stand at $417.1 million (Q1 2026), $140.0 million (Q4 2025), and -$34.2 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -22.03 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -2.44 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 243.78 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 417.10 Mn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn -153.10 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -
9 Revolution Medicines 37.37 Bn 37.37 Bn - 57.19 Mn
10 Alnylam Pharmaceuticals 36.08 Bn 33.07 Bn 959.66 Mn 53.61 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 417.10 Mn
Dec 31, 2025 140.00 Mn
Sep 30, 2025 -34.20 Mn
Jun 30, 2025 296.60 Mn
Mar 31, 2025 113.20 Mn
Dec 31, 2024 -675.90 Mn
Sep 30, 2024 657.10 Mn
Jun 30, 2024 -4.58 Bn
Mar 31, 2024 -1.20 Bn
Dec 31, 2023 -744.30 Mn
Sep 30, 2023 963.20 Mn
Jun 30, 2023 857.80 Mn
Mar 31, 2023 -1.22 Bn
Dec 31, 2022 1.34 Bn
Sep 30, 2022 472.90 Mn
Jun 30, 2022 1.10 Bn
Mar 31, 2022 803.90 Mn
Dec 31, 2021 519.90 Mn
Sep 30, 2021 209.10 Mn
Jun 30, 2021 -241.80 Mn