Stoke Therapeutics (STOK) Operating Margin (2022 - 2026)
Stoke Therapeutics' Operating Margin came in at -701.65% for Q2 2026, down 504.07 percentage points from -197.58% a year earlier but up 155.92 percentage points from the prior quarter.
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Analysis
Stoke Therapeutics (STOK) Operating Margin (2022 - 2026) Analysis & Trends
Over the trailing twelve months to Jun 30, 2026, Stoke Therapeutics reported Operating Margin of -809.69%, down 829.84 percentage points year-over-year; for FY2025, it came in at -11.16%, up 266.15 percentage points from FY2024.
- Operating Margin carries a three-year change of +830.08 percentage points (FY2022 to FY2025).
- Going back by year, Operating Margin was -277.31% in FY2024 (+1029.90 pp), -1307.21% in FY2023 (-465.97 pp) and -841.24% in FY2022.
- The five-year range for quarterly Operating Margin is -4382.24% (Q4 2025) to 70.15% (Q1 2025).
- Year-over-year, Operating Margin has declined for three consecutive quarters, with an average year-over-year change of -398.41 percentage points over the last eight quarters.
- The fastest year-over-year change in Operating Margin over five years came in Q4 2024 (a gain of 995.51 percentage points), and the weakest in Q4 2025 (a drop of 4321.87 percentage points).
- Business Quant data shows STOK's Operating Margin at -857.57% (Q1 2026), -4382.24% (Q4 2025) and -405.30% (Q3 2025) in the three quarters before Q2 2026.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Operating Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 655.56 Bn | 574.09 Bn | 17.26 Bn | 28.21% |
| 2 | AbbVie | 470.94 Bn | 444.10 Bn | 12.70 Bn | 37.86% |
| 3 | Merck | 367.14 Bn | 321.57 Bn | 12.21 Bn | -3.52% |
| 4 | Novartis Ag | 280.33 Bn | 236.20 Bn | 11.24 Bn | 32.97% |
| 5 | Astrazeneca | 257.78 Bn | 231.34 Bn | 12.86 Bn | 20.57% |
| 6 | Amgen | 226.04 Bn | 181.44 Bn | 7.24 Bn | 34.95% |
| 7 | Gilead Sciences | 188.89 Bn | 163.01 Bn | 6.22 Bn | -133.21% |
| 8 | Pfizer | 163.75 Bn | 110.70 Bn | 10.94 Bn | 28.37% |
| 9 | Vertex Pharmaceuticals | 133.68 Bn | 105.69 Bn | 2.84 Bn | 37.40% |
| 10 | Stoke Therapeutics | 1.59 Bn | 421.92 Mn | - | -701.65% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -701.65% |
| Mar 31, 2026 | -857.57% |
| Dec 31, 2025 | -4,382.24% |
| Sep 30, 2025 | -405.30% |
| Jun 30, 2025 | -197.58% |
| Mar 31, 2025 | 70.15% |
| Dec 31, 2024 | -60.37% |
| Sep 30, 2024 | -613.06% |
| Jun 30, 2024 | -607.37% |
| Mar 31, 2024 | -672.96% |
| Dec 31, 2023 | -1,055.89% |
| Sep 30, 2023 | -823.28% |
| Jun 30, 2023 | -1,340.67% |
| Mar 31, 2023 | -479.23% |
| Dec 31, 2022 | -831.58% |
| Sep 30, 2022 | -934.53% |
| Jun 30, 2022 | -781.12% |
| Mar 31, 2022 | -826.50% |
API Access
Stoke Therapeutics Operating Margin API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=operating-margin&ticker=STOK&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "operating-margin", "ticker": "STOK", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=operating-margin&ticker=STOK&period=max&api_key=YOUR_API_KEY");
const data = await res.json();