Spero Therapeutics (SPRO) Return on Equity [ROE] (2017 - 2026)
Spero Therapeutics (SPRO) posted Return on Equity [ROE] of 15.22% for Q2 2026, up 176.22 percentage points from -161.00% a year earlier but down 12.01 percentage points from the prior quarter.
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Analysis
Spero Therapeutics (SPRO) Return on Equity [ROE] (2017 - 2026) Analysis & Trends
For FY2025, Spero Therapeutics' Return on Equity [ROE] came in at 16.36%, up 106.02 percentage points from FY2024.
- Annual Return on Equity [ROE] shows a five-year change of +92.13 percentage points (FY2020 to FY2025).
- In prior years, Spero Therapeutics' Return on Equity [ROE] was -89.66% in FY2024 (-114.61 pp), 24.95% in FY2023 (+81.47 pp), -56.53% in FY2022 (+24.99 pp) and -81.51% in FY2021 (-5.74 pp).
- Quarterly Return on Equity [ROE] has run from a low of -299.59% in Q3 2022 to a high of 28.42% in Q4 2023 over five years.
- On a year-over-year basis, Return on Equity [ROE] has increased in each of the last three quarters, with an average year-over-year change of -19.21 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Return on Equity [ROE] in the past five years was Q3 2023, with a gain of 296.61 percentage points; the weakest was Q3 2022, with a drop of 221.33 percentage points.
- According to Business Quant data, Return on Equity [ROE] for the three prior quarters was 27.23% (Q1 2026), 19.99% (Q4 2025) and -148.01% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,136.97 Bn | 1,105.55 Bn | 19.71 Bn | 82.09% |
| 2 | Johnson & Johnson | 619.72 Bn | 538.25 Bn | 17.26 Bn | 25.32% |
| 3 | AbbVie | 503.40 Bn | 476.52 Bn | 12.70 Bn | - |
| 4 | Merck | 370.15 Bn | 324.53 Bn | 12.21 Bn | 7.21% |
| 5 | Novartis Ag | 298.64 Bn | 262.63 Bn | 11.24 Bn | 31.52% |
| 6 | Astrazeneca | 261.07 Bn | 234.76 Bn | 12.86 Bn | 21.39% |
| 7 | Amgen | 237.00 Bn | 192.40 Bn | 7.24 Bn | 83.75% |
| 8 | Gilead Sciences | 191.24 Bn | 165.43 Bn | 6.22 Bn | -18.38% |
| 9 | Pfizer | 170.31 Bn | 116.96 Bn | 10.94 Bn | 4.97% |
| 10 | Spero Therapeutics | 68.40 Mn | -127.38 Mn | - | 15.22% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | 15.22% |
| Mar 31, 2026 | 27.23% |
| Dec 31, 2025 | 19.99% |
| Sep 30, 2025 | -148.01% |
| Jun 30, 2025 | -161.00% |
| Mar 31, 2025 | -174.76% |
| Dec 31, 2024 | -122.99% |
| Sep 30, 2024 | 4.74% |
| Jun 30, 2024 | 19.69% |
| Mar 31, 2024 | 23.03% |
| Dec 31, 2023 | 28.42% |
| Sep 30, 2023 | -2.98% |
| Jun 30, 2023 | -16.86% |
| Mar 31, 2023 | -38.15% |
| Dec 31, 2022 | -85.62% |
| Sep 30, 2022 | -299.59% |
| Jun 30, 2022 | -230.33% |
| Mar 31, 2022 | -136.91% |
| Dec 31, 2021 | -89.72% |
| Sep 30, 2021 | -78.26% |
API Access
Spero Therapeutics Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SPRO&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "SPRO", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=SPRO&period=max&api_key=YOUR_API_KEY");
const data = await res.json();