Spero Therapeutics SPRO
NASDAQ SPRO
$1.17 -0.02 (-1.68%)
At close: Sep 9, 2026 · 4:00 PM EDT

Spero Therapeutics (SPRO) Price to Book (2017 - 2026)

Spero Therapeutics' (SPRO) quarterly Price to Book came in at 2.91 in Q2 2026, down 41.43% on a YoY basis from 4.96 in Q2 2025, and up 13.6% quarter-over-quarter from 2.56 in Q1 2026.

Analysis

Spero Therapeutics (SPRO) Price to Book (2017 - 2026) Analysis & Trends

Spero Therapeutics (SPRO) has reported Price to Book for 10 consecutive years, with 2.91 the latest figure, recorded in Q2 2026.

  • For the quarter ending Q2 2026, Price to Book fell 41.43% year-over-year to 2.91; the trailing twelve-month figure through Jun 2026 stood at 2.91 (down 41.43% YoY), and the FY2025 full-year result was 2.23, up 82.68% from the prior year.
  • Price to Book climbed to 2.91 in Q2 2026 per SPRO's latest filing, from 2.56 in the prior quarter.
  • Across five years, Price to Book topped out at 4.96 in Q2 2025 and bottomed at 0.72 in Q2 2022.
  • Historically, Price to Book has averaged 1.96 across 5 years, with a median of 1.21 in 2023.
  • The sharpest annual moves came in 2022 and 2025: Price to Book plunged 85.42% in 2022, then jumped 469.08% in 2025.
  • Over 5 years, Price to Book stood at 0.86 in 2022, then dropped by 14.88% to 0.73 in 2023, then soared by 67.27% to 1.22 in 2024, then soared by 82.68% to 2.23 in 2025, then soared by 30.53% to 2.91 in 2026.
  • According to Business Quant data, Price to Book over the past three periods registered 2.91, 2.56, and 2.23 for Q2 2026, Q1 2026, and Q4 2025 respectively.
Peer Set

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr)
1 Amgen 211.73 Bn 197.74 Bn 7.24 Bn
2 Gilead Sciences 180.92 Bn 177.74 Bn 6.22 Bn
3 Vertex Pharmaceuticals 132.16 Bn 124.30 Bn 2.84 Bn
4 Regeneron Pharmaceuticals 82.89 Bn 74.90 Bn 3.93 Bn
5 Argenx Se 61.41 Bn 56.23 Bn 1.37 Bn
6 Moderna 53.99 Bn 48.85 Bn 52.00 Mn
7 Alnylam Pharmaceuticals 34.48 Bn 31.18 Bn 992.69 Mn
8 Biogen 31.15 Bn 29.86 Bn 1.96 Bn
9 Roivant Sciences 30.05 Bn 30.05 Bn 1.16 Mn
10 Spero Therapeutics 67.82 Mn 17.05 Mn -
Historic Data

Historic Data

Download Data
DateValue
Jun 30, 2026 2.91
Mar 31, 2026 2.56
Dec 31, 2025 2.23
Sep 30, 2025 4.00
Jun 30, 2025 4.96
Mar 31, 2025 1.19
Dec 31, 2024 1.22
Sep 30, 2024 1.11
Jun 30, 2024 0.87
Mar 31, 2024 0.96
Dec 31, 2023 0.73
Sep 30, 2023 1.19
Jun 30, 2023 1.39
Mar 31, 2023 1.18
Dec 31, 2022 0.86
Sep 30, 2022 2.64
Jun 30, 2022 0.72
Mar 31, 2022 4.56
Dec 31, 2021 5.87
Sep 30, 2021 5.30