Replimune (REPL) Operating Expenses (2017 - 2025)

Replimune's (REPL) quarterly Operating Expenses came in at $71.9 million in Q4 2025, up 8.86% year-on-year from $66.0 million in Q4 2024, and down 14.74% quarter-over-quarter from $84.3 million in Q3 2025.

Replimune (REPL) Operating Expenses (2017 - 2025) Analysis & Trends

Replimune has disclosed Operating Expenses across 9 years of filings, most recently posting $71.9 million for Q4 2025.

  • Operating Expenses for Q4 2025 came in at $71.9 million, up 8.86% year-over-year; the trailing twelve-month figure through Dec 2025 was $325.9 million (up 35.2% YoY), and the FY2025 annual result was $261.6 million, up 11.44% from the prior year.
  • Operating Expenses came in at $71.9 million for Q4 2025 at Replimune, down from $84.3 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $90.4 million in Q2 2025 to a low of $22.2 million in Q1 2021.
  • The 5-year median for Operating Expenses is $56.1 million (2023), against an average of $53.0 million.
  • Across the five-year window, Operating Expenses surged 65.67% in 2023 and retreated 7.7% in 2024, its largest moves.
  • Replimune's Operating Expenses stood at $29.7 million in 2021, then soared by 40.18% to $41.6 million in 2022, then surged by 35.82% to $56.5 million in 2023, then increased by 16.77% to $66.0 million in 2024, then grew by 8.86% to $71.9 million in 2025.
  • The last three Operating Expenses figures came in at $71.9 million (Q4 2025), $84.3 million (Q3 2025), and $90.4 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 762,369.55 Bn 762,369.51 Bn - 4.33 Mn
2 Belite Bio 55,096.00 Bn 55,096.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,755.80 Bn 17,755.79 Bn - 2.97 Mn
4 Legend Biotech 3,486.00 Bn 3,485.71 Bn 242.10 Mn -138.30 Mn
5 Akari Therapeutics 1,737.42 Bn 1,737.41 Bn - 15.76 Mn
6 Evaxion A 1,551.28 Bn 1,551.26 Bn - -3.82 Mn
7 Psyence Biomedical 227.32 Bn 227.31 Bn - 574,669.00
8 Vertex Pharmaceuticals 110.84 Bn 103.59 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.71 Bn 91.71 Bn - -67.40 Mn
10 Replimune 780.01 Mn 510.88 Mn - 71.87 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 71.87 Mn
Sep 30, 2025 84.29 Mn
Jun 30, 2025 90.42 Mn
Mar 31, 2025 79.33 Mn
Dec 31, 2024 66.02 Mn
Sep 30, 2024 58.92 Mn
Jun 30, 2024 57.37 Mn
Mar 31, 2024 58.76 Mn
Dec 31, 2023 56.54 Mn
Sep 30, 2023 63.83 Mn
Jun 30, 2023 55.65 Mn
Mar 31, 2023 53.00 Mn
Dec 31, 2022 41.63 Mn
Sep 30, 2022 41.58 Mn
Jun 30, 2022 40.88 Mn
Mar 31, 2022 31.99 Mn
Dec 31, 2021 29.70 Mn
Sep 30, 2021 29.25 Mn
Jun 30, 2021 27.38 Mn
Mar 31, 2021 22.18 Mn