Replimune (REPL) Operating Expenses (2017 - 2025)
Replimune's (REPL) quarterly Operating Expenses came in at $71.9 million in Q4 2025, up 8.86% year-on-year from $66.0 million in Q4 2024, and down 14.74% quarter-over-quarter from $84.3 million in Q3 2025.
Replimune (REPL) Operating Expenses (2017 - 2025) Analysis & Trends
Replimune has disclosed Operating Expenses across 9 years of filings, most recently posting $71.9 million for Q4 2025.
- Operating Expenses for Q4 2025 came in at $71.9 million, up 8.86% year-over-year; the trailing twelve-month figure through Dec 2025 was $325.9 million (up 35.2% YoY), and the FY2025 annual result was $261.6 million, up 11.44% from the prior year.
- Operating Expenses came in at $71.9 million for Q4 2025 at Replimune, down from $84.3 million in the prior quarter.
- In the past five years, Operating Expenses ranged from a high of $90.4 million in Q2 2025 to a low of $22.2 million in Q1 2021.
- The 5-year median for Operating Expenses is $56.1 million (2023), against an average of $53.0 million.
- Across the five-year window, Operating Expenses surged 65.67% in 2023 and retreated 7.7% in 2024, its largest moves.
- Replimune's Operating Expenses stood at $29.7 million in 2021, then soared by 40.18% to $41.6 million in 2022, then surged by 35.82% to $56.5 million in 2023, then increased by 16.77% to $66.0 million in 2024, then grew by 8.86% to $71.9 million in 2025.
- The last three Operating Expenses figures came in at $71.9 million (Q4 2025), $84.3 million (Q3 2025), and $90.4 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 762,369.55 Bn | 762,369.51 Bn | - | 4.33 Mn |
| 2 | Belite Bio | 55,096.00 Bn | 55,096.00 Bn | - | 32.68 Mn |
| 3 | Quantum Biopharma | 17,755.80 Bn | 17,755.79 Bn | - | 2.97 Mn |
| 4 | Legend Biotech | 3,486.00 Bn | 3,485.71 Bn | 242.10 Mn | -138.30 Mn |
| 5 | Akari Therapeutics | 1,737.42 Bn | 1,737.41 Bn | - | 15.76 Mn |
| 6 | Evaxion A | 1,551.28 Bn | 1,551.26 Bn | - | -3.82 Mn |
| 7 | Psyence Biomedical | 227.32 Bn | 227.31 Bn | - | 574,669.00 |
| 8 | Vertex Pharmaceuticals | 110.84 Bn | 103.59 Bn | 2.59 Bn | 1.85 Bn |
| 9 | Abivax | 91.71 Bn | 91.71 Bn | - | -67.40 Mn |
| 10 | Replimune | 780.01 Mn | 510.88 Mn | - | 71.87 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 71.87 Mn |
| Sep 30, 2025 | 84.29 Mn |
| Jun 30, 2025 | 90.42 Mn |
| Mar 31, 2025 | 79.33 Mn |
| Dec 31, 2024 | 66.02 Mn |
| Sep 30, 2024 | 58.92 Mn |
| Jun 30, 2024 | 57.37 Mn |
| Mar 31, 2024 | 58.76 Mn |
| Dec 31, 2023 | 56.54 Mn |
| Sep 30, 2023 | 63.83 Mn |
| Jun 30, 2023 | 55.65 Mn |
| Mar 31, 2023 | 53.00 Mn |
| Dec 31, 2022 | 41.63 Mn |
| Sep 30, 2022 | 41.58 Mn |
| Jun 30, 2022 | 40.88 Mn |
| Mar 31, 2022 | 31.99 Mn |
| Dec 31, 2021 | 29.70 Mn |
| Sep 30, 2021 | 29.25 Mn |
| Jun 30, 2021 | 27.38 Mn |
| Mar 31, 2021 | 22.18 Mn |