Pyxis Oncology (PYXS) Free Cash Flow (2020 - 2025)

Pyxis Oncology's (PYXS) quarterly Free Cash Flow came in at -$10.4 million in Q4 2025, up 45.95% year-on-year from -$7.1 million in Q4 2024, and up 21.47% on a QoQ basis from -$13.3 million in Q3 2025.

Pyxis Oncology (PYXS) Free Cash Flow (2020 - 2025) Analysis & Trends

Pyxis Oncology (PYXS) has 6 years of Free Cash Flow data on file, last reported at -$10.4 million in Q4 2025.

  • On a quarterly basis, Free Cash Flow rose 45.95% year-over-year to -$10.4 million in Q4 2025; TTM through Dec 2025 was -$63.5 million, a 9.66% decrease from a year earlier, with the FY2025 full-year figure at -$63.5 million, down 9.67% from the prior year.
  • Free Cash Flow for Q4 2025 stood at -$10.4 million, up from -$13.3 million in the prior quarter.
  • Over the last five years, Free Cash Flow for PYXS reached as high as $2.5 million in Q2 2021 and fell as low as -$29.1 million in Q1 2023.
  • Historically, Free Cash Flow has averaged -$16.2 million across 5 years, with a median of -$17.5 million in 2023.
  • Across the five-year window, Free Cash Flow slumped 1049.3% in 2022 and surged 80.52% in 2024, its largest moves.
  • Year by year, Free Cash Flow stood at -$12.2 million in 2021, then tumbled by 84.29% to -$22.4 million in 2022, then surged by 60.92% to -$8.8 million in 2023, then tumbled by 120.08% to -$19.3 million in 2024, then surged by 45.95% to -$10.4 million in 2025.
  • Per Business Quant data, the three most recent Free Cash Flow figures were -$10.4 million in Q4 2025, -$13.3 million in Q3 2025, and -$17.3 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -19.58 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 158.09 Mn
4 NuCana 279.75 Bn 279.75 Bn - -1.53 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.29 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 848.30 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - -354.95 Mn
10 Pyxis Oncology 166.54 Mn 99.69 Mn 8.65 Mn -10.43 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -10.43 Mn
Dec 31, 2025 -10.43 Mn
Sep 30, 2025 -13.28 Mn
Sep 30, 2025 -13.28 Mn
Jun 30, 2025 -17.26 Mn
Jun 30, 2025 -17.26 Mn
Mar 31, 2025 -22.54 Mn
Mar 31, 2025 -22.54 Mn
Dec 31, 2024 -19.29 Mn
Dec 31, 2024 -19.29 Mn
Sep 30, 2024 -14.67 Mn
Sep 30, 2024 -14.67 Mn
Jun 30, 2024 -3.01 Mn
Jun 30, 2024 -3.01 Mn
Mar 31, 2024 -20.95 Mn
Mar 31, 2024 -20.95 Mn
Dec 31, 2023 -8.77 Mn
Dec 31, 2023 -8.77 Mn
Sep 30, 2023 -17.64 Mn
Sep 30, 2023 -17.64 Mn