Pyxis Oncology (PYXS) Enterprise Value (2020 - 2025)
Pyxis Oncology (PYXS) reported Enterprise Value of -$16.9 million for Q4 2025, up 19.34% year-over-year from -$14.2 million in Q4 2024, and down 62.58% quarter-over-quarter from -$10.4 million in Q3 2025.
Pyxis Oncology (PYXS) Enterprise Value (2020 - 2025) Analysis & Trends
Pyxis Oncology (PYXS) has 6 years of Enterprise Value data on file, last reported at -$16.9 million in Q4 2025.
- Enterprise Value for Q4 2025 came in at -$16.9 million, up 19.34% year-over-year; the trailing twelve-month figure through Dec 2025 was -$16.9 million (up 19.34% YoY), and the FY2025 annual result was -$16.9 million, up 19.34% from the prior year.
- Enterprise Value retreated to -$16.9 million in Q4 2025 per PYXS's latest filing, from -$10.4 million in the prior quarter.
- Over five years, Enterprise Value peaked at -$10.4 million in Q3 2025 and troughed at -$276.2 million in Q4 2021.
- A 5-year average of -$116.0 million and a median of -$126.1 million in 2023 frame the typical range for Enterprise Value.
- The sharpest annual moves came in 2021 and 2024: Enterprise Value plunged 1086.88% in 2021, then surged 89.83% in 2024.
- A 5-year view of Enterprise Value shows it stood at -$276.2 million in 2021, then surged by 34.55% to -$180.8 million in 2022, then soared by 34.0% to -$119.3 million in 2023, then soared by 82.44% to -$20.9 million in 2024, then climbed by 19.34% to -$16.9 million in 2025.
- Business Quant data shows PYXS's Enterprise Value at -$16.9 million in Q4 2025, -$10.4 million in Q3 2025, and -$88.9 million in Q2 2025.
Powered by 
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Enterprise Value (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | -32.30 Mn |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -4.14 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -286.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -18.44 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.77 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -7.20 Mn |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | -7.25 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -584.73 Mn |
| 10 | Pyxis Oncology | 125.84 Mn | 108.95 Mn | 8.65 Mn | -16.89 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -16.89 Mn |
| Sep 30, 2025 | -10.39 Mn |
| Jun 30, 2025 | -88.94 Mn |
| Mar 31, 2025 | -105.43 Mn |
| Dec 31, 2024 | -20.95 Mn |
| Sep 30, 2024 | -13.53 Mn |
| Jun 30, 2024 | -26.55 Mn |
| Mar 31, 2024 | -157.03 Mn |
| Dec 31, 2023 | -119.30 Mn |
| Sep 30, 2023 | -132.97 Mn |
| Jun 30, 2023 | -27.37 Mn |
| Mar 31, 2023 | -54.53 Mn |
| Dec 31, 2022 | -180.77 Mn |
| Sep 30, 2022 | -200.01 Mn |
| Jun 30, 2022 | -224.83 Mn |
| Mar 31, 2022 | -248.56 Mn |
| Dec 31, 2021 | -276.21 Mn |
| Sep 30, 2021 | -133.48 Mn |
| Jun 30, 2021 | -142.47 Mn |
| Mar 31, 2021 | -140.66 Mn |