Pyxis Oncology (PYXS) EBITDA (2020 - 2025)
Pyxis Oncology (PYXS) reported EBITDA of -$18.1 million for Q4 2025, up 49.31% year-over-year from -$12.1 million in Q4 2024, and up 17.36% quarter-over-quarter from -$21.9 million in Q3 2025.
Pyxis Oncology (PYXS) EBITDA (2020 - 2025) Analysis & Trends
Pyxis Oncology (PYXS) has 6 years of EBITDA data on file, last reported at -$18.1 million in Q4 2025.
- EBITDA for Q4 2025 came in at -$18.1 million, up 49.31% year-over-year; the trailing twelve-month figure through Dec 2025 was -$79.7 million (down 3.26% YoY), and the FY2025 annual result was -$79.7 million, down 3.26% from the prior year.
- EBITDA improved to -$18.1 million in Q4 2025 per PYXS's latest filing, from -$21.9 million in the prior quarter.
- Over five years, EBITDA peaked at -$3.4 million in Q1 2024 and troughed at -$36.1 million in Q4 2022.
- A 5-year average of -$21.1 million and a median of -$19.6 million in 2023 frame the typical range for EBITDA.
- The sharpest annual moves came in 2024 and 2025: EBITDA surged 81.78% in 2024, then plunged 529.74% in 2025.
- A 5-year view of EBITDA shows it stood at -$16.4 million in 2021, then plunged by 119.78% to -$36.1 million in 2022, then jumped by 57.26% to -$15.4 million in 2023, then tumbled by 131.72% to -$35.8 million in 2024, then jumped by 49.31% to -$18.1 million in 2025.
- Business Quant data shows PYXS's EBITDA at -$18.1 million in Q4 2025, -$21.9 million in Q3 2025, and -$18.4 million in Q2 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -3.82 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -14.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -65.83 Mn |
| 10 | Pyxis Oncology | 125.84 Mn | 108.95 Mn | 8.65 Mn | -18.12 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -18.12 Mn |
| Sep 30, 2025 | -21.93 Mn |
| Jun 30, 2025 | -18.41 Mn |
| Mar 31, 2025 | -21.28 Mn |
| Dec 31, 2024 | -35.75 Mn |
| Sep 30, 2024 | -20.75 Mn |
| Jun 30, 2024 | -17.34 Mn |
| Mar 31, 2024 | -3.38 Mn |
| Dec 31, 2023 | -15.43 Mn |
| Sep 30, 2023 | -23.07 Mn |
| Jun 30, 2023 | -16.68 Mn |
| Mar 31, 2023 | -18.55 Mn |
| Dec 31, 2022 | -36.10 Mn |
| Sep 30, 2022 | -27.67 Mn |
| Jun 30, 2022 | -25.56 Mn |
| Mar 31, 2022 | -31.38 Mn |
| Dec 31, 2021 | -16.43 Mn |
| Sep 30, 2021 | -11.62 Mn |
| Jun 30, 2021 | -5.94 Mn |
| Mar 31, 2021 | -35.73 Mn |