Pyxis Oncology (PYXS) Change in Cash (2020 - 2025)
Pyxis Oncology (PYXS) reported Change in Cash of $6.5 million for Q4 2025, down 12.32% year-over-year from $7.4 million in Q4 2024, and up 458.49% quarter-over-quarter from -$1.8 million in Q3 2025.
Pyxis Oncology (PYXS) Change in Cash (2020 - 2025) Analysis & Trends
Pyxis Oncology (PYXS) has 6 years of Change in Cash data on file, last reported at $6.5 million in Q4 2025.
- Change in Cash for Q4 2025 came in at $6.5 million, down 12.32% year-over-year; the trailing twelve-month figure through Dec 2025 was -$4.1 million (down 141.3% YoY), and the FY2025 annual result was -$4.1 million, down 141.3% from the prior year.
- Change in Cash improved to $6.5 million in Q4 2025 per PYXS's latest filing, from -$1.8 million in the prior quarter.
- Over five years, Change in Cash peaked at $142.7 million in Q4 2021 and troughed at -$126.2 million in Q1 2023.
- A 5-year average of $435300.0 and a median of -$5.9 million in 2023 frame the typical range for Change in Cash.
- The sharpest annual moves came in 2021 and 2022: Change in Cash surged 4608.24% in 2021, then slumped 1417.86% in 2022.
- A 5-year view of Change in Cash shows it stood at $142.7 million in 2021, then sank by 113.48% to -$19.2 million in 2022, then soared by 73.75% to -$5.1 million in 2023, then jumped by 246.84% to $7.4 million in 2024, then retreated by 12.32% to $6.5 million in 2025.
- Business Quant data shows PYXS's Change in Cash at $6.5 million in Q4 2025, -$1.8 million in Q3 2025, and -$2.0 million in Q2 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Change in Cash (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | - |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | - |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 2.44 Mn |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | 623.00 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | - |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | -2.44 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | - |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 417.10 Mn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -45.97 Mn |
| 10 | Pyxis Oncology | 125.84 Mn | 108.95 Mn | 8.65 Mn | 6.50 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | 6.50 Mn |
| Sep 30, 2025 | -1.81 Mn |
| Jun 30, 2025 | -2.03 Mn |
| Mar 31, 2025 | -6.71 Mn |
| Dec 31, 2024 | 7.42 Mn |
| Sep 30, 2024 | -13.02 Mn |
| Jun 30, 2024 | -2.89 Mn |
| Mar 31, 2024 | 18.30 Mn |
| Dec 31, 2023 | -5.05 Mn |
| Sep 30, 2023 | -11.18 Mn |
| Jun 30, 2023 | -27.16 Mn |
| Mar 31, 2023 | -126.23 Mn |
| Dec 31, 2022 | -19.25 Mn |
| Sep 30, 2022 | -24.82 Mn |
| Jun 30, 2022 | -23.84 Mn |
| Mar 31, 2022 | -27.65 Mn |
| Dec 31, 2021 | 142.73 Mn |
| Sep 30, 2021 | -9.00 Mn |
| Jun 30, 2021 | 1.81 Mn |
| Mar 31, 2021 | 132.58 Mn |