Pyxis Oncology (PYXS) Change in Cash (2020 - 2025)

Pyxis Oncology (PYXS) reported Change in Cash of $6.5 million for Q4 2025, down 12.32% year-over-year from $7.4 million in Q4 2024, and up 458.49% quarter-over-quarter from -$1.8 million in Q3 2025.

Pyxis Oncology (PYXS) Change in Cash (2020 - 2025) Analysis & Trends

Pyxis Oncology (PYXS) has 6 years of Change in Cash data on file, last reported at $6.5 million in Q4 2025.

  • Change in Cash for Q4 2025 came in at $6.5 million, down 12.32% year-over-year; the trailing twelve-month figure through Dec 2025 was -$4.1 million (down 141.3% YoY), and the FY2025 annual result was -$4.1 million, down 141.3% from the prior year.
  • Change in Cash improved to $6.5 million in Q4 2025 per PYXS's latest filing, from -$1.8 million in the prior quarter.
  • Over five years, Change in Cash peaked at $142.7 million in Q4 2021 and troughed at -$126.2 million in Q1 2023.
  • A 5-year average of $435300.0 and a median of -$5.9 million in 2023 frame the typical range for Change in Cash.
  • The sharpest annual moves came in 2021 and 2022: Change in Cash surged 4608.24% in 2021, then slumped 1417.86% in 2022.
  • A 5-year view of Change in Cash shows it stood at $142.7 million in 2021, then sank by 113.48% to -$19.2 million in 2022, then soared by 73.75% to -$5.1 million in 2023, then jumped by 246.84% to $7.4 million in 2024, then retreated by 12.32% to $6.5 million in 2025.
  • Business Quant data shows PYXS's Change in Cash at $6.5 million in Q4 2025, -$1.8 million in Q3 2025, and -$2.0 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.44 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 623.00 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.44 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 417.10 Mn
9 Abivax 91.96 Bn 91.96 Bn - -45.97 Mn
10 Pyxis Oncology 125.84 Mn 108.95 Mn 8.65 Mn 6.50 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 6.50 Mn
Sep 30, 2025 -1.81 Mn
Jun 30, 2025 -2.03 Mn
Mar 31, 2025 -6.71 Mn
Dec 31, 2024 7.42 Mn
Sep 30, 2024 -13.02 Mn
Jun 30, 2024 -2.89 Mn
Mar 31, 2024 18.30 Mn
Dec 31, 2023 -5.05 Mn
Sep 30, 2023 -11.18 Mn
Jun 30, 2023 -27.16 Mn
Mar 31, 2023 -126.23 Mn
Dec 31, 2022 -19.25 Mn
Sep 30, 2022 -24.82 Mn
Jun 30, 2022 -23.84 Mn
Mar 31, 2022 -27.65 Mn
Dec 31, 2021 142.73 Mn
Sep 30, 2021 -9.00 Mn
Jun 30, 2021 1.81 Mn
Mar 31, 2021 132.58 Mn