Pyxis Oncology (PYXS) Change in Cash (2020 - 2025)

Pyxis Oncology's (PYXS) quarterly Change in Cash came in at $6.5 million in Q4 2025, down 12.32% year-on-year from $7.4 million in Q4 2024, and up 458.49% on a QoQ basis from -$1.8 million in Q3 2025.

Pyxis Oncology (PYXS) Change in Cash (2020 - 2025) Analysis & Trends

Pyxis Oncology (PYXS) has 6 years of Change in Cash data on file, last reported at $6.5 million in Q4 2025.

  • On a quarterly basis, Change in Cash fell 12.32% year-over-year to $6.5 million in Q4 2025; TTM through Dec 2025 was -$4.1 million, a 141.3% decrease from a year earlier, with the FY2025 full-year figure at -$4.1 million, down 141.3% from the prior year.
  • Change in Cash for Q4 2025 stood at $6.5 million, up from -$1.8 million in the prior quarter.
  • Over the last five years, Change in Cash for PYXS reached as high as $142.7 million in Q4 2021 and fell as low as -$126.2 million in Q1 2023.
  • Historically, Change in Cash has averaged $435300.0 across 5 years, with a median of -$5.9 million in 2023.
  • Across the five-year window, Change in Cash soared 4608.24% in 2021 and plunged 1417.86% in 2022, its largest moves.
  • Year by year, Change in Cash stood at $142.7 million in 2021, then slumped by 113.48% to -$19.2 million in 2022, then soared by 73.75% to -$5.1 million in 2023, then jumped by 246.84% to $7.4 million in 2024, then dropped by 12.32% to $6.5 million in 2025.
  • Per Business Quant data, the three most recent Change in Cash figures were $6.5 million in Q4 2025, -$1.8 million in Q3 2025, and -$2.0 million in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Change in Cash (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -22.03 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 243.78 Mn
4 NuCana 279.75 Bn 279.75 Bn - -1.34 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 417.10 Mn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn -153.10 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn -
9 Revolution Medicines 37.78 Bn 37.78 Bn - 57.19 Mn
10 Pyxis Oncology 166.54 Mn 99.69 Mn 8.65 Mn 6.50 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 6.50 Mn
Sep 30, 2025 -1.81 Mn
Jun 30, 2025 -2.03 Mn
Mar 31, 2025 -6.71 Mn
Dec 31, 2024 7.42 Mn
Sep 30, 2024 -13.02 Mn
Jun 30, 2024 -2.89 Mn
Mar 31, 2024 18.30 Mn
Dec 31, 2023 -5.05 Mn
Sep 30, 2023 -11.18 Mn
Jun 30, 2023 -27.16 Mn
Mar 31, 2023 -126.23 Mn
Dec 31, 2022 -19.25 Mn
Sep 30, 2022 -24.82 Mn
Jun 30, 2022 -23.84 Mn
Mar 31, 2022 -27.65 Mn
Dec 31, 2021 142.73 Mn
Sep 30, 2021 -9.00 Mn
Jun 30, 2021 1.81 Mn
Mar 31, 2021 132.58 Mn