Pyxis Oncology (PYXS) Cash from Operations (2020 - 2025)

Pyxis Oncology (PYXS) reported Cash from Operations of 10427000.0 for Q4 2025, up 45.95% year-over-year from 7144419.07 in Q4 2024, and up 21.47% quarter-over-quarter from 13277000.0 in Q3 2025.

Pyxis Oncology (PYXS) Cash from Operations (2020 - 2025) Analysis & Trends

Pyxis Oncology (PYXS) has 6 years of Cash from Operations data on file, last reported at 10427000.0 in Q4 2025.

  • Cash from Operations for Q4 2025 came in at 10427000.0, up 45.95% year-over-year; the trailing twelve-month figure through Dec 2025 was 63502000.0 (down 10.11% YoY), and the FY2025 annual result was 63502000.0, down 10.11% from the prior year.
  • Cash from Operations rose to 10427000.0 in Q4 2025 per PYXS's latest filing, from 13277000.0 in the prior quarter.
  • Over five years, Cash from Operations peaked at 2862000.0 in Q2 2021 and troughed at 27679000.0 in Q1 2022.
  • A 5-year average of 15827200.0 and a median of 17325000.0 in 2022 frame the typical range for Cash from Operations.
  • The sharpest annual moves came in 2022 and 2024: Cash from Operations plunged 928.51% in 2022, then soared 72.74% in 2024.
  • A 5-year view of Cash from Operations shows it stood at 12169000.0 in 2021, then plunged by 42.88% to 17387000.0 in 2022, then advanced by 12.27% to 15254000.0 in 2023, then dropped by 26.46% to 19290000.0 in 2024, then surged by 45.95% to 10427000.0 in 2025.
  • Business Quant data shows PYXS's Cash from Operations at 10427000.0 in Q4 2025, 13277000.0 in Q3 2025, and 17263000.0 in Q2 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Ops. (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - -1.67 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -12.20 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -2.49 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.43 Bn
9 Abivax 91.96 Bn 91.96 Bn - -
10 Pyxis Oncology 125.84 Mn 108.95 Mn 8.65 Mn -10.43 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -10.43 Mn
Dec 31, 2025 -10.43 Mn
Sep 30, 2025 -13.28 Mn
Sep 30, 2025 -13.28 Mn
Jun 30, 2025 -17.26 Mn
Jun 30, 2025 -17.26 Mn
Mar 31, 2025 -22.54 Mn
Mar 31, 2025 -22.54 Mn
Dec 31, 2024 -19.29 Mn
Dec 31, 2024 -19.29 Mn
Sep 30, 2024 -14.67 Mn
Sep 30, 2024 -14.67 Mn
Jun 30, 2024 -3.01 Mn
Jun 30, 2024 -3.01 Mn
Mar 31, 2024 -20.71 Mn
Mar 31, 2024 -20.71 Mn
Dec 31, 2023 -15.25 Mn
Dec 31, 2023 -15.25 Mn
Sep 30, 2023 -17.58 Mn
Sep 30, 2023 -17.58 Mn