Protagonist Therapeutics (PTGX) Return on Capital Employed (2016 - 2026)

Protagonist Therapeutics' (PTGX) quarterly Return on Capital Employed came in at 21.98% in Q1 2026, up 159.0% year-on-year from 8.48% in Q1 2025, and up 11.12% quarter-over-quarter from 24.73% in Q4 2025.

Protagonist Therapeutics (PTGX) Return on Capital Employed (2016 - 2026) Analysis & Trends

Protagonist Therapeutics has disclosed Return on Capital Employed across 11 years of filings, most recently posting 21.98% for Q1 2026.

  • Return on Capital Employed for Q1 2026 came in at 21.98%, up 159.0% year-over-year; the trailing twelve-month figure through Mar 2026 was 21.98% (up 159.0% YoY), and the FY2025 annual result was 23.92%, down 3557.0% from the prior year.
  • Return on Capital Employed came in at 21.98% for Q1 2026 at Protagonist Therapeutics, up from 24.73% in the prior quarter.
  • In the past five years, Return on Capital Employed ranged from a high of 49.76% in Q1 2024 to a low of 66.29% in Q1 2023.
  • The 5-year median for Return on Capital Employed is 24.73% (2025), against an average of 20.99%.
  • Across the five-year window, Return on Capital Employed surged 11605 bps in 2024 and sank 7333 bps in 2025, its largest moves.
  • Protagonist Therapeutics' Return on Capital Employed stood at 56.17% in 2022, then surged by 91 bps to 5.14% in 2023, then soared by 282 bps to 9.36% in 2024, then tumbled by 364 bps to 24.73% in 2025, then grew by 11 bps to 21.98% in 2026.
  • The last three Return on Capital Employed figures came in at 21.98% (Q1 2026), 24.73% (Q4 2025), and 26.34% (Q3 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) ROCE (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - -
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - -
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 450.31%
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn 51.73%
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - -107.40%
7 Psyence Biomedical 212.16 Bn 212.16 Bn - -
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 21.10%
9 Abivax 91.96 Bn 91.96 Bn - -50.43%
10 Protagonist Therapeutics 7.35 Bn 7.35 Bn - -21.98%

Historic Data

Download Data
DateValue
Mar 31, 2026 -21.98%
Dec 31, 2025 -24.73%
Sep 30, 2025 -26.34%
Jun 30, 2025 -24.50%
Mar 31, 2025 -23.57%
Dec 31, 2024 9.36%
Sep 30, 2024 40.06%
Jun 30, 2024 39.51%
Mar 31, 2024 49.76%
Dec 31, 2023 -5.14%
Sep 30, 2023 -51.52%
Jun 30, 2023 -58.00%
Mar 31, 2023 -66.29%
Dec 31, 2022 -56.17%
Sep 30, 2022 -50.80%
Jun 30, 2022 -46.14%
Mar 31, 2022 -40.37%
Dec 31, 2021 -39.77%
Sep 30, 2021 -30.80%
Jun 30, 2021 -26.45%