Protagonist Therapeutics, Inc (PTGX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

71,284,932Shares Outstanding

4,442,633Shares held by institutions

$366,339,517Value of institutional holdings

99.89%Institutional ownership %

11.13%Shares Changed QoQ

275No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Protagonist Therapeutics, Inc (NASDAQ:PTGX) currently has 296 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The percentage of Protagonist Therapeutics owned by institutions changed from 99.8% in September 2025 to 96.0% in December 2025, marking a slight down trend.
Quarterly data indicates a 11.77% shift in institutional share volume, and the annual owner count reflects an increase of 23.33%.
Among the 296 institutional holders of Protagonist Therapeutics, 171 added to their stakes while 95 trimmed their positions and 30 held steady.
Collectively, institutional investors increased their stake in Protagonist Therapeutics to 67.79Mn shares as of December 2025, a change that is up by 7.14Mn shares quarter on quarter and up 4.42Mn shares year over year.
With 9.72Mn shares, BlackRock, Inc. commands the largest institutional position in Protagonist Therapeutics as of December 31, 2025, equating to 13.76% of the company.
Among the most significant buyers of Protagonist Therapeutics during December 2025 were JANUS HENDERSON GROUP PLC (1.55Mn), WELLINGTON MANAGEMENT GROUP LLP (1.26Mn), VANGUARD GROUP INC (1.16Mn), CITADEL ADVISORS LLC (888.81K), UBS Group AG (874.01K).
Leading sellers of Protagonist Therapeutics stock in December 2025 included Jefferies Financial Group Inc. (816.50K), RTW INVESTMENTS, LP (697.22K), Commodore Capital LP (575.00K), ADAGE CAPITAL PARTNERS GP, L.L.C. (485.37K), Pictet Asset Management Holding SA (292.58K).
The top 10 institutional holders of Protagonist Therapeutics for the quarter ending December 2025 included BlackRock, Inc. (9.72Mn), FARALLON CAPITAL MANAGEMENT LLC (6.14Mn), VANGUARD GROUP INC (5.41Mn), RTW INVESTMENTS, LP (5.06Mn), STATE STREET CORP (3.20Mn), WELLINGTON MANAGEMENT GROUP LLP (3.17Mn), UBS Group AG (2.77Mn), JANUS HENDERSON GROUP PLC (2.65Mn), JOHNSON & JOHNSON (2.45Mn), GEODE CAPITAL MANAGEMENT, LLC (1.45Mn).

296 Institutional Holders

4,442,633 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	9,715,999	311,767	3.32%	$848,595,367.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	6,144,006	-52,000	-0.84%	$536,617,484.00
VANGUARD GROUP INC	31 Dec, 2025	5,413,690	1,156,461	27.16%	$472,831,684.00
RTW INVESTMENTS, LP	31 Dec, 2025	5,059,053	-697,224	-12.11%	$441,857,689.00
STATE STREET CORP	31 Dec, 2025	3,199,729	33,934	1.07%	$279,464,331.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,171,423	1,262,977	66.18%	$276,992,086.00
UBS Group AG	31 Dec, 2025	2,770,021	874,013	46.10%	$241,933,634.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	2,649,981	1,549,160	140.73%	$231,354,837.00
JOHNSON & JOHNSON	31 Dec, 2025	2,449,183	0	0.00%	$213,911,643.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,452,928	36,282	2.56%	$126,919,578.00
Woodline Partners LP	31 Dec, 2025	1,408,772	-29,475	-2.05%	$123,042,146.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,350,425	320,291	31.09%	$117,946,120.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,126,687	888,806	373.63%	$98,404,842.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,099,170	-40,684	-3.57%	$96,001,508.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,049,168	59,986	6.06%	$91,634,333.00
MARSHALL WACE, LLP	31 Dec, 2025	1,024,925	-60,639	-5.59%	$89,516,950.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	961,149	179,438	22.95%	$83,946,754.00
MORGAN STANLEY	31 Dec, 2025	879,024	110,665	14.40%	$76,774,142.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	867,580	37,703	4.54%	$75,774,437.00
NORTHERN TRUST CORP	31 Dec, 2025	575,118	-28,104	-4.66%	$50,230,807.00

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