Protagonist Therapeutics, Inc (PTGX) Institutional Ownership

Institutions by Trading Activity

63,450,000Shares Outstanding

146Shares held by institutions

$11,712Value of institutional holdings

0.04%Institutional ownership %

-46.99%Shares Changed QoQ

4No. of institutional investors

According to SEC filings for the period ending December 2025, Protagonist Therapeutics, Inc (NASDAQ:PTGX) is held by 4 institutional firms.

Institutional ownership in Protagonist Therapeutics edged down to 0.0% in December 2025, compared to 111.1% in September 2025.
In percentage terms, this reflects as a holdings change of -46.99% quarter on quarter, and a decrease of 98.33% year over year.
Among the 4 institutional holders of Protagonist Therapeutics, 1 added to their stakes while 1 trimmed their positions and 2 held steady.
This class of investors decreased its holdings in Protagonist Therapeutics to 22.82K shares for the 13F-cycle ending December 2025, down by 20.23K shares quarter on quarter, and down 63.35Mn shares year over year.
SG Americas Securities, LLC continues to be the largest institutional holder of Protagonist Therapeutics as of December 31, 2025, with a position of 20.00K shares, representing 0.03% of the company's outstanding stock.
Among the most significant buyers of Protagonist Therapeutics during December 2025 were GAMMA Investing LLC (1.02K).
Leading sellers of Protagonist Therapeutics stock in December 2025 included SG Americas Securities, LLC (21.25K).
The top 4 institutional holders of Protagonist Therapeutics for the quarter ending December 2025 included SG Americas Securities, LLC (20.00K), GAMMA Investing LLC (2.67K), MassMutual Private Wealth & Trust, FSB (119), Versant Capital Management, Inc (27).

146 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	30 Sep, 2025	9,404,232	-226,109	-2.35%	$624,723,149.00
FARALLON CAPITAL MANAGEMENT LLC	30 Sep, 2025	6,196,006	24,000	0.39%	$411,600,679.00
RTW INVESTMENTS, LP	30 Sep, 2025	5,756,277	0	0.00%	$382,389,481.00
VANGUARD GROUP INC	30 Sep, 2025	4,257,229	-101,366	-2.33%	$282,807,724.00
STATE STREET CORP	30 Sep, 2025	3,165,795	-41,748	-1.30%	$210,303,762.00
BVF INC/IL	30 Sep, 2025	2,560,916	-650,125	-20.25%	$170,121,650.00
JOHNSON & JOHNSON	30 Sep, 2025	2,449,183	0	0.00%	$162,699,227.00
WELLINGTON MANAGEMENT GROUP LLP	30 Sep, 2025	1,908,446	870,708	83.90%	$126,778,068.00
UBS Group AG	30 Sep, 2025	1,896,008	-605,243	-24.20%	$125,951,812.00
Deep Track Capital, LP	30 Sep, 2025	1,715,691	-1,530,208	-47.14%	$113,973,353.00
Woodline Partners LP	30 Sep, 2025	1,438,247	491,363	51.89%	$95,542,748.00
GEODE CAPITAL MANAGEMENT, LLC	30 Sep, 2025	1,416,646	-27,584	-1.91%	$94,122,036.00
PRICE T ROWE ASSOCIATES INC /MD/	30 Sep, 2025	1,220,436	283,733	30.29%	$81,075.00
DRIEHAUS CAPITAL MANAGEMENT LLC	30 Sep, 2025	1,139,854	382,144	50.43%	$75,720,501.00
JANUS HENDERSON GROUP PLC	30 Sep, 2025	1,100,821	653,993	146.36%	$73,165,449.00
MARSHALL WACE, LLP	30 Sep, 2025	1,085,564	1,085,564	0.00%	$72,114,017.00
PERCEPTIVE ADVISORS LLC	30 Sep, 2025	1,030,134	-44,314	-4.12%	$68,431,802.00
Commodore Capital LP	30 Sep, 2025	1,025,000	-50,000	-4.65%	$68,090,750.00
Invesco Ltd.	30 Sep, 2025	1,003,706	282,026	39.08%	$66,676,188.00
ADAR1 Capital Management, LLC	30 Sep, 2025	989,182	41,113	4.34%	$65,711,360.00

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