Protagonist Therapeutics, Inc (PTGX) Institutional Ownership

Institutions by Trading Activity

63,772,332Shares Outstanding

73,723,770Shares held by institutions

$7,653,264,564Value of institutional holdings

115.60%Institutional ownership %

2.26%Shares Changed QoQ

303No. of institutional investors

Protagonist Therapeutics, Inc (NASDAQ:PTGX) has 303 institutional investors with active 13F positions as of December 2025.

These investors collectively held 110.2% of Protagonist Therapeutics's outstanding shares in December 2025, down from 122.1% in September 2025.
Their total shares held in PTGX increased 1.37% quarter over quarter, and separately, investors owning Protagonist Therapeutics increased 26.78% from a year ago.
Activity in PTGX broke down as 169 buyers, 103 sellers, and 31 unchanged among 303 total holders.
Combined, these investors held 70.3Mn shares in PTGX for December 2025, up by 953.12K shares quarter on quarter, and up 2.83Mn shares year over year.
Sankala Group LLC holds the largest position in PTGX at 60 shares as of December 31, 2025, or 0.0% of shares outstanding.
Protagonist Therapeutics's 1 largest shareholders as of December 2025 include Sankala Group LLC (60) per Business Quant data.

73,723,770 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	9,715,999	311,767	3.32%	$848,595,367.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	6,144,006	-6,248,006	-50.42%	$536,617,484.00
VANGUARD GROUP INC	31 Dec, 2025	5,413,690	1,156,461	27.16%	$472,831,684.00
RTW INVESTMENTS, LP	31 Dec, 2025	5,059,053	-697,224	-12.11%	$441,857,689.00
Johnson & Johnson	31 Dec, 2025	4,898,366	0	0.00%	$427,823,286.00
State Street Corp	31 Dec, 2025	3,199,729	33,934	1.07%	$279,464,331.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,171,423	1,262,977	66.18%	$276,992,086.00
UBS Group AG	31 Dec, 2025	2,770,021	874,013	46.10%	$241,933,634.00
Janus Henderson Group Plc	31 Dec, 2025	2,649,981	1,549,160	140.73%	$231,354,837.00
ADAR1 Capital Management, LLC	31 Dec, 2025	2,098,336	1,109,154	112.13%	$183,268,666.00
Goldman Sachs Group Inc	31 Dec, 2025	1,922,298	1,140,587	145.91%	$167,893,508.00
Invesco Ltd.	31 Dec, 2025	1,567,840	564,134	56.21%	$136,935,146.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,452,928	36,282	2.56%	$126,919,578.00
Woodline Partners LP	31 Dec, 2025	1,408,772	-29,475	-2.05%	$123,042,146.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,350,425	320,291	31.09%	$117,946,120.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,126,687	888,806	373.63%	$98,404,842.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,099,170	-40,684	-3.57%	$96,001,508.00
MARSHALL WACE, LLP	31 Dec, 2025	1,024,925	-60,639	-5.59%	$89,516,950.00
Morgan Stanley	31 Dec, 2025	879,024	110,665	14.40%	$76,774,142.00
Bank Of America Corp /De/	31 Dec, 2025	867,580	-792,174	-47.73%	$75,774,437.00

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