Protagonist Therapeutics, Inc (PTGX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

63,772,332Shares Outstanding

73,828,770Shares held by institutions

$7,309,048,230Value of institutional holdings

115.77%Institutional ownership %

2.40%Shares Changed QoQ

303No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Protagonist Therapeutics, Inc (NASDAQ:PTGX) showed up in the 13F filings of 303 institutional investors as of December 2025.

These investors collectively held 110.2% of Protagonist Therapeutics's outstanding shares in December 2025, down from 122.1% in September 2025.
They increased total shares held in Protagonist Therapeutics by 1.37% from the prior quarter, while the number of investors in PTGX increased 26.78% year over year.
During the quarter, 169 of these 303 funds increased positions in PTGX, 103 reduced exposure, and 31 held steady.
Altogether, these fund groups held 70.3Mn shares in PTGX by December 2025, up by 953.12K shares quarter on quarter, and up 2.83Mn shares year over year.
As of December 31, 2025, the biggest holder of Protagonist Therapeutics is Pictet Asset Management Holding SA at 581.08K shares, representing 0.91% of shares outstanding.
Leading buyers of Protagonist Therapeutics shares for the quarter ending December 2025 were Pictet Asset Management Holding SA (51.45K), E Fund Management Co., Ltd. (6.03K), KEYBANK NATIONAL ASSOCIATION/OH (4.29K), WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (3.66K), NORDEN GROUP LLC (2.81K).
Leading sellers of Protagonist Therapeutics shares for the quarter ending December 2025 were MOODY ALDRICH PARTNERS LLC (26.73K), EXCHANGE TRADED CONCEPTS, LLC (11.27K), PSP Research LLC (3.12K), SG Americas Securities, LLC (1.9K), State of Alaska, Department of Revenue (952).
Per Business Quant, the top 10 investors in PTGX for the quarter ending December 2025 include Pictet Asset Management Holding SA (581.08K), MOODY ALDRICH PARTNERS LLC (53.89K), State of Alaska, Department of Revenue (37.15K), Louisiana State Employees Retirement System (26.1K), EXCHANGE TRADED CONCEPTS, LLC (23.77K), SG Americas Securities, LLC (18.1K), YOUSIF CAPITAL MANAGEMENT, LLC (16.23K), STRS OHIO (15.4K), FRANKLIN STREET ADVISORS INC /NC (11.08K), Cache Advisors, LLC (10.14K).

303 Institutional Holders

73,828,770 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	9,715,999	311,767	3.32%	$848,595,367.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	6,144,006	-6,248,006	-50.42%	$536,617,484.00
VANGUARD GROUP INC	31 Dec, 2025	5,413,690	1,156,461	27.16%	$472,831,684.00
RTW INVESTMENTS, LP	31 Dec, 2025	5,059,053	-697,224	-12.11%	$441,857,689.00
Johnson & Johnson	31 Dec, 2025	4,898,366	0	0.00%	$427,823,286.00
State Street Corp	31 Dec, 2025	3,199,729	33,934	1.07%	$279,464,331.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	3,171,423	1,262,977	66.18%	$276,992,086.00
UBS Group AG	31 Dec, 2025	2,770,021	874,013	46.10%	$241,933,634.00
Janus Henderson Group Plc	31 Dec, 2025	2,649,981	1,549,160	140.73%	$231,354,837.00
ADAR1 Capital Management, LLC	31 Dec, 2025	2,098,336	1,109,154	112.13%	$183,268,666.00
Goldman Sachs Group Inc	31 Dec, 2025	1,922,298	1,140,587	145.91%	$167,893,508.00
Invesco Ltd.	31 Dec, 2025	1,567,840	564,134	56.21%	$136,935,146.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,452,928	36,282	2.56%	$126,919,578.00
Woodline Partners LP	31 Dec, 2025	1,408,772	-29,475	-2.05%	$123,042,146.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,350,425	320,291	31.09%	$117,946,120.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,126,687	888,806	373.63%	$98,404,842.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,099,170	-40,684	-3.57%	$96,001,508.00
MARSHALL WACE, LLP	31 Dec, 2025	1,024,925	-60,639	-5.59%	$89,516,950.00
Morgan Stanley	31 Dec, 2025	879,024	110,665	14.40%	$76,774,142.00
Bank Of America Corp /De/	31 Dec, 2025	867,580	-792,174	-47.73%	$75,774,437.00

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