Protagonist Therapeutics, Inc (PTGX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

4,357,188Shares held by institutions

$433,670,922Value of institutional holdings

111.33%Institutional ownership %

7.36%Shares Changed QoQ

271No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Protagonist Therapeutics, Inc (NASDAQ:PTGX) showed up in the 13F filings of 303 institutional investors as of December 2025.

Their combined ownership stood at 110.2% of outstanding shares in December 2025, down from 122.1% in September 2025.
They increased total shares held in Protagonist Therapeutics by 1.37% from the prior quarter, while the number of investors in PTGX increased 26.78% year over year.
Of these 303 holders, 169 added to their stakes in Protagonist Therapeutics, 103 trimmed positions, and 31 made no changes.
Combined, these investors held 70.3Mn shares in PTGX for December 2025, up by 953.12K shares quarter on quarter, and up 2.83Mn shares year over year.
BlackRock, Inc. is the top holder of Protagonist Therapeutics as of December 31, 2025, with 9.72Mn shares representing 15.24% of outstanding stock.
The most significant purchases of PTGX for the quarter ending December 2025 came from Janus Henderson Group Plc (1.55Mn), WELLINGTON MANAGEMENT GROUP LLP (1.26Mn), VANGUARD GROUP INC (1.16Mn), ADAR1 Capital Management, LLC (1.11Mn), CITADEL ADVISORS LLC (888.81K).
The largest sellers of Protagonist Therapeutics for the quarter ending December 2025 were FARALLON CAPITAL MANAGEMENT LLC (6.25Mn), Jefferies Financial Group Inc. (816.5K), Bank Of America Corp /De/ (792.17K), RTW INVESTMENTS, LP (697.22K), Commodore Capital LP (575.0K).
According to Business Quant data, leading holders of PTGX for December 2025 are BlackRock, Inc. (9.72Mn), FARALLON CAPITAL MANAGEMENT LLC (6.14Mn), VANGUARD GROUP INC (5.41Mn), RTW INVESTMENTS, LP (5.06Mn), State Street Corp (3.2Mn), WELLINGTON MANAGEMENT GROUP LLP (3.17Mn), UBS Group AG (2.77Mn), Janus Henderson Group Plc (2.65Mn), Johnson & Johnson (2.45Mn), ADAR1 Capital Management, LLC (2.1Mn).

303 Institutional Holders

4,357,188 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	311,767	3.32%	$0.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	-6,248,006	-50.42%	$0.00
UBS Group AG	31 Dec, 2025	874,013	46.10%	$0.00
Johnson & Johnson	31 Dec, 2025	0	0.00%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	1,156,461	27.16%	$0.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,109,154	112.13%	$0.00
Barclays Plc	31 Dec, 2025	-110,759	-37.12%	$0.00
RTW INVESTMENTS, LP	31 Dec, 2025	-697,224	-12.11%	$0.00
Woodline Partners LP	31 Dec, 2025	-29,475	-2.05%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	3,604	120.94%	$0.00
State Street Corp	31 Dec, 2025	33,934	1.07%	$0.00
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	31 Dec, 2025	571,825	0.00%	$0.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,262,977	66.18%	$0.00
Pictet Asset Management Holding SA	31 Dec, 2025	-292,581	-35.58%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	1,549,160	140.73%	$0.00
Commodore Capital LP	31 Dec, 2025	-575,000	-56.10%	$0.00
NEXTBio Capital Management LP	31 Dec, 2025	229,619	0.00%	$0.00
Invesco Ltd.	31 Dec, 2025	564,134	56.21%	$0.00
Holocene Advisors, LP	31 Dec, 2025	210,019	0.00%	$0.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	36,282	2.56%	$0.00

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