Puma Biotechnology (PBYI) Gross Margin (2017 - 2026)
Puma Biotechnology (PBYI) posted Gross Margin of 76.74% for Q1 2026, up 10.66% on a QoQ basis from 69.35% in Q4 2025, and down 32.0% year-over-year from 112.85% in Q1 2025.
Puma Biotechnology (PBYI) Gross Margin (2017 - 2026) Analysis & Trends
Puma Biotechnology's Gross Margin history runs 10 years deep, the most recent figure standing at 76.74% for Q1 2026.
- Quarterly Gross Margin fell 32.0% year-over-year to 76.74% in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 74.46% (up 206.0% YoY) and the FY2025 annual result came in at 74.53%, up 248.0% from the prior year.
- Gross Margin was 76.74% for Q1 2026 at Puma Biotechnology, up from 69.35% in the prior quarter.
- Across five years, Gross Margin topped out at 80.79% in Q4 2022 and bottomed at 63.87% in Q3 2024.
- A 5-year average of 75.09% and a median of 76.44% in 2024 frame the typical range for Gross Margin.
- Annual changes were most pronounced in 2023 — Gross Margin sank 1449 bps — and 2025, when it jumped 1378 bps.
- Puma Biotechnology's Gross Margin stood at 80.79% in 2022, then fell by 18 bps to 66.3% in 2023, then rose by 15 bps to 76.44% in 2024, then decreased by 9 bps to 69.35% in 2025, then advanced by 11 bps to 76.74% in 2026.
- Business Quant data shows PBYI's Gross Margin at 76.74% in Q1 2026, 69.35% in Q4 2025, and 77.65% in Q3 2025.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Gross Margin (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 68,785.72 Bn | 68,785.72 Bn | - | - |
| 2 | Nanobiotix | 1,895.57 Bn | 1,895.51 Bn | - | - |
| 3 | BeOne Medicines | 471.35 Bn | 466.56 Bn | 1.35 Bn | 88.95% |
| 4 | NuCana | 279.75 Bn | 279.75 Bn | - | - |
| 5 | Vertex Pharmaceuticals | 120.24 Bn | 113.00 Bn | 2.59 Bn | 86.85% |
| 6 | Regeneron Pharmaceuticals | 67.80 Bn | 59.04 Bn | 3.31 Bn | 91.79% |
| 7 | Belite Bio | 62.51 Bn | 62.51 Bn | - | - |
| 8 | Argenx Se | 57.38 Bn | 57.38 Bn | 1.41 Bn | 90.68% |
| 9 | Revolution Medicines | 37.78 Bn | 37.78 Bn | - | - |
| 10 | Puma Biotechnology | 407.27 Mn | 368.99 Mn | 34.39 Mn | 76.74% |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 76.74% |
| Dec 31, 2025 | 69.35% |
| Sep 30, 2025 | 77.65% |
| Jun 30, 2025 | 76.54% |
| Mar 31, 2025 | 77.06% |
| Dec 31, 2024 | 76.44% |
| Sep 30, 2024 | 63.87% |
| Jun 30, 2024 | 77.36% |
| Mar 31, 2024 | 75.49% |
| Dec 31, 2023 | 66.30% |
| Sep 30, 2023 | 76.33% |
| Jun 30, 2023 | 78.27% |
| Mar 31, 2023 | 74.95% |
| Dec 31, 2022 | 80.79% |
| Sep 30, 2022 | 78.12% |
| Jun 30, 2022 | 74.94% |
| Mar 31, 2022 | 76.29% |
| Dec 31, 2021 | 78.51% |
| Sep 30, 2021 | 77.77% |
| Jun 30, 2021 | 77.58% |