Puma Biotechnology, Inc. (PBYI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

50,929,893Shares Outstanding

36,192,660Shares held by institutions

$260,949,079Value of institutional holdings

71.06%Institutional ownership %

8.93%Shares Changed QoQ

146No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Puma Biotechnology, Inc. (NASDAQ:PBYI) appears in 146 institutional 13F filings for the quarter ending December 2025.

Collectively, these holders controlled 69.5% of Puma Biotechnology's outstanding shares in December 2025, up from 67.7% in September 2025.
Their total shares held in PBYI increased 7.05% from the prior quarter, while the number of investors in Puma Biotechnology increased 29.2% year over year.
Activity in PBYI broke down as 79 buyers, 42 sellers, and 25 unchanged among 146 total holders.
Combined, these investors held 35.4Mn shares in PBYI for December 2025, up by 2.33Mn shares quarter on quarter, and up 613.81K shares year over year.
ACORN CAPITAL ADVISORS, LLC holds the largest position in PBYI at 4.13Mn shares as of December 31, 2025, or 8.11% of shares outstanding.
The biggest buyers of Puma Biotechnology for the quarter ending December 2025 included Goldman Sachs Group Inc (1.35Mn), AQR CAPITAL MANAGEMENT LLC (535.93K), BRIDGEWAY CAPITAL MANAGEMENT, LLC (339.92K), O'SHAUGHNESSY ASSET MANAGEMENT, LLC (292.11K), Empowered Funds, LLC (252.81K).
Leading sellers of Puma Biotechnology shares for the quarter ending December 2025 were Russell Investments Group, Ltd. (713.04K), UBS Group AG (248.78K), Universal- Beteiligungs- und Servicegesellschaft mbH (159.2K), Barclays Plc (156.35K), LSV ASSET MANAGEMENT (155.12K).
Per Business Quant data, the top 10 holders of Puma Biotechnology for the quarter ending December 2025 are ACORN CAPITAL ADVISORS, LLC (4.13Mn), VANGUARD GROUP INC (3.8Mn), BlackRock, Inc. (3.64Mn), RENAISSANCE TECHNOLOGIES LLC (2.12Mn), ACADIAN ASSET MANAGEMENT LLC (2.02Mn), AMERICAN CENTURY COMPANIES INC (1.65Mn), Goldman Sachs Group Inc (1.59Mn), DIMENSIONAL FUND ADVISORS LP (1.34Mn), O'SHAUGHNESSY ASSET MANAGEMENT, LLC (1.12Mn), GEODE CAPITAL MANAGEMENT, LLC (994.34K).

146 Institutional Holders

36,192,660 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ACORN CAPITAL ADVISORS, LLC	31 Dec, 2025	4,131,299	0	0.00%	$24,581,229.00
VANGUARD GROUP INC	31 Dec, 2025	3,797,748	106,028	2.87%	$22,596,600.00
BlackRock, Inc.	31 Dec, 2025	3,642,588	64,711	1.81%	$21,673,399.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	2,123,813	-27,400	-1.27%	$12,636,687.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	2,024,823	-28,482	-1.39%	$12,043.00
AMERICAN CENTURY COMPANIES INC	31 Dec, 2025	1,650,137	166,949	11.26%	$9,818,315.00
Goldman Sachs Group Inc	31 Dec, 2025	1,587,924	1,353,307	576.82%	$9,448,148.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,339,603	67,725	5.32%	$7,971,040.00
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	31 Dec, 2025	1,120,329	292,108	35.27%	$6,665,958.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	994,345	10,823	1.10%	$5,917,285.00
State Street Corp	31 Dec, 2025	877,077	128,419	17.15%	$5,218,608.00
Connor, Clark & Lunn Investment Management Ltd.	31 Dec, 2025	875,301	-68,171	-7.23%	$5,208,041.00
KENNEDY CAPITAL MANAGEMENT LLC	31 Dec, 2025	868,315	685	0.08%	$5,166,474.00
BRIDGEWAY CAPITAL MANAGEMENT, LLC	31 Dec, 2025	773,485	339,924	78.40%	$4,602,236.00
RITHOLTZ WEALTH MANAGEMENT	31 Dec, 2025	694,001	223,234	47.42%	$4,129,306.00
AQR CAPITAL MANAGEMENT LLC	31 Dec, 2025	666,605	535,933	410.14%	$3,966,300.00
Northern Trust Corp	31 Dec, 2025	616,197	89,461	16.98%	$3,666,372.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	547,853	83,119	17.89%	$3,259,725.00
GLOBEFLEX CAPITAL L P	31 Dec, 2025	452,606	0	0.00%	$2,693,006.00
Sei Investments Co	31 Dec, 2025	429,925	82,691	23.81%	$2,558,037.00

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