Puma Biotechnology, Inc. (PBYI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

49,304,000Shares Outstanding

4,917,658Shares held by institutions

$33,194,192Value of institutional holdings

70.88%Institutional ownership %

6.37%Shares Changed QoQ

143No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 143 institutions have reported a stake in Puma Biotechnology, Inc. (NASDAQ:PBYI) as of December 2025, according to recent 13F filings with the SEC.

These investors collectively held 70.9% of the company's total shares outstanding in December 2025, up from 70.0% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 6.37%, with a year-over-year an increase of 26.55% in the count of filers.
The latest 13F cycle for Puma Biotechnology reveals that of 143 total investors, 79 funds grew their exposure, whereas 38 reduced theirs and 26 made no changes.
Collectively, institutional investors increased their stake in Puma Biotechnology to 34.95Mn shares as of December 2025, a change that is up by 2.09Mn shares quarter on quarter and up 5.55Mn shares year over year.
ACORN CAPITAL ADVISORS, LLC continues to be the largest institutional holder of Puma Biotechnology as of December 31, 2025, with a position of 4.13Mn shares, representing 8.38% of the company's outstanding stock.
Among the most significant buyers of Puma Biotechnology during December 2025 were GOLDMAN SACHS GROUP INC (559.35K), AQR CAPITAL MANAGEMENT LLC (535.93K), BRIDGEWAY CAPITAL MANAGEMENT, LLC (339.92K), O'SHAUGHNESSY ASSET MANAGEMENT, LLC (292.11K), RITHOLTZ WEALTH MANAGEMENT (223.23K).
Leading sellers of Puma Biotechnology stock in December 2025 included Russell Investments Group, Ltd. (713.04K), UBS Group AG (248.78K), Universal- Beteiligungs- und Servicegesellschaft mbH (159.20K), LSV ASSET MANAGEMENT (155.12K), LOS ANGELES CAPITAL MANAGEMENT LLC (125.92K).
The top 10 institutional holders of Puma Biotechnology for the quarter ending December 2025 included ACORN CAPITAL ADVISORS, LLC (4.13Mn), VANGUARD GROUP INC (3.80Mn), BlackRock, Inc. (3.64Mn), RENAISSANCE TECHNOLOGIES LLC (2.12Mn), ACADIAN ASSET MANAGEMENT LLC (2.02Mn), AMERICAN CENTURY COMPANIES INC (1.65Mn), DIMENSIONAL FUND ADVISORS LP (1.34Mn), O'SHAUGHNESSY ASSET MANAGEMENT, LLC (1.12Mn), GEODE CAPITAL MANAGEMENT, LLC (994.35K), STATE STREET CORP (877.08K).

143 Institutional Holders

4,917,658 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ACORN CAPITAL ADVISORS, LLC	31 Dec, 2025	4,131,299	0	0.00%	$24,581,229.00
VANGUARD GROUP INC	31 Dec, 2025	3,797,748	106,028	2.87%	$22,596,600.00
BlackRock, Inc.	31 Dec, 2025	3,642,588	64,711	1.81%	$21,673,399.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	2,123,813	-27,400	-1.27%	$12,636,687.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	2,024,823	-28,482	-1.39%	$12,043.00
AMERICAN CENTURY COMPANIES INC	31 Dec, 2025	1,650,137	166,949	11.26%	$9,818,315.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,339,603	67,725	5.32%	$7,971,040.00
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	31 Dec, 2025	1,120,329	292,108	35.27%	$6,665,958.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	994,345	10,823	1.10%	$5,917,285.00
STATE STREET CORP	31 Dec, 2025	877,077	128,419	17.15%	$5,218,608.00
Connor, Clark & Lunn Investment Management Ltd.	31 Dec, 2025	875,301	-68,171	-7.23%	$5,208,041.00
KENNEDY CAPITAL MANAGEMENT LLC	31 Dec, 2025	868,315	685	0.08%	$5,166,474.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	793,962	559,345	238.41%	$4,724,074.00
BRIDGEWAY CAPITAL MANAGEMENT, LLC	31 Dec, 2025	773,485	339,924	78.40%	$4,602,236.00
RITHOLTZ WEALTH MANAGEMENT	31 Dec, 2025	694,001	223,234	47.42%	$4,129,306.00
AQR CAPITAL MANAGEMENT LLC	31 Dec, 2025	666,605	535,933	410.14%	$3,966,300.00
NORTHERN TRUST CORP	31 Dec, 2025	616,197	89,461	16.98%	$3,666,372.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	547,853	83,119	17.89%	$3,259,725.00
GLOBEFLEX CAPITAL L P	31 Dec, 2025	452,606	0	0.00%	$2,693,006.00
SEI INVESTMENTS CO	31 Dec, 2025	429,925	82,691	23.81%	$2,558,037.00

1 - 20 of 143

Research Tools