Puma Biotechnology, Inc. (PBYI) Institutional Ownership

Ownership Summary

Puma Biotechnology, Inc. (NASDAQ:PBYI) appears in 146 institutional 13F filings for the quarter ending December 2025.

• They owned 69.5% of outstanding stock in December 2025, up from 67.7% the prior quarter.
• Their total shares held in PBYI increased 7.05% quarter over quarter, and separately, investors owning Puma Biotechnology increased 29.2% from a year ago.
• During the quarter, 79 of these 146 funds increased positions in PBYI, 42 reduced exposure, and 25 held steady.
• Institutional investors collectively held 35.4Mn shares in Puma Biotechnology as of December 2025, up by 2.33Mn shares quarter on quarter, and up 613.81K shares year over year.
• ACORN CAPITAL ADVISORS, LLC holds the largest position in PBYI at 4.13Mn shares as of December 31, 2025, or 8.11% of shares outstanding.
• The biggest buyers of Puma Biotechnology for the quarter ending December 2025 included VANGUARD CAPITAL MANAGEMENT LLC (1.82Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (1.73Mn), MILLENNIUM MANAGEMENT LLC (1.46Mn), LSV ASSET MANAGEMENT (778.07K), UBS Group AG (406.92K).
• Top sellers of PBYI stock for the quarter ending December 2025 included Goldman Sachs Group Inc (918.2K), RENAISSANCE TECHNOLOGIES LLC (181.4K), Empowered Funds, LLC (168.33K), TWO SIGMA INVESTMENTS, LP (149.35K), CITADEL ADVISORS LLC (132.71K).
• Per Business Quant, the top 10 investors in PBYI for the quarter ending December 2025 include ACORN CAPITAL ADVISORS, LLC (4.13Mn), BlackRock, Inc. (3.6Mn), ACADIAN ASSET MANAGEMENT LLC (2.04Mn), RENAISSANCE TECHNOLOGIES LLC (1.94Mn), AMERICAN CENTURY COMPANIES INC (1.92Mn), VANGUARD CAPITAL MANAGEMENT LLC (1.82Mn), VANGUARD PORTFOLIO MANAGEMENT LLC (1.73Mn), MILLENNIUM MANAGEMENT LLC (1.48Mn), DIMENSIONAL FUND ADVISORS LP (1.44Mn), LSV ASSET MANAGEMENT (1.18Mn).