Krystal Biotech (KRYS) Gross Margin (2023 - 2026)

Krystal Biotech (KRYS) reported Gross Margin of 94.57% for Q1 2026, up 27.0% on a YoY basis from 74.46% in Q1 2025, and up 0.77% sequentially from 93.85% in Q4 2025.

Krystal Biotech (KRYS) Gross Margin (2023 - 2026) Analysis & Trends

Krystal Biotech (KRYS) has 4 years of Gross Margin data on file, last reported at 94.57% in Q1 2026.

  • For the quarter ending Q1 2026, Gross Margin rose 27.0% year-over-year to 94.57%; the trailing twelve-month figure through Mar 2026 stood at 94.17% (up 97.0% YoY), and the FY2025 full-year result was 94.08%, up 98.0% from the prior year.
  • Gross Margin improved to 94.57% in Q1 2026, from 93.85% in the prior quarter.
  • In the past five years, Gross Margin ranged from a high of 97.39% in Q3 2023 to a low of 91.45% in Q2 2024.
  • A 4-year average of 94.02% and a median of 94.3% in 2025 frame the typical range for Gross Margin.
  • Across the five-year window, Gross Margin plunged 537 bps in 2024 and surged 361 bps in 2025, its largest moves.
  • Tracing KRYS's Gross Margin over 4 years: stood at 93.19% in 2023, then grew by 1 bps to 94.57% in 2024, then retreated by 1 bps to 93.85% in 2025, then climbed by 1 bps to 94.57% in 2026.
  • Business Quant data shows KRYS's Gross Margin at 94.57% in Q1 2026, 93.85% in Q4 2025, and 95.64% in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Gross Margin (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 88.95%
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 86.85%
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 91.79%
7 Belite Bio 61.40 Bn 61.40 Bn - -
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn 90.68%
9 Revolution Medicines 37.37 Bn 37.37 Bn - -
10 Krystal Biotech 9.84 Bn 9.02 Bn 110.08 Mn 94.57%

Historic Data

Download Data
DateValue
Mar 31, 2026 94.57%
Dec 31, 2025 93.85%
Sep 30, 2025 95.64%
Jun 30, 2025 92.54%
Mar 31, 2025 94.30%
Dec 31, 2024 94.57%
Sep 30, 2024 92.03%
Jun 30, 2024 91.45%
Mar 31, 2024 94.65%
Dec 31, 2023 93.19%
Sep 30, 2023 97.39%