Karyopharm Therapeutics (KPTI) Return on Sales (2012 - 2026)
Karyopharm Therapeutics' (KPTI) quarterly Return on Sales came in at 0.04% in Q4 2025, up 2.0% YoY from 0.04% in Q4 2024, and up 612.59% on a QoQ basis from 0.01% in Q3 2025.
Karyopharm Therapeutics (KPTI) Return on Sales (2012 - 2026) Analysis & Trends
Karyopharm Therapeutics (KPTI) has 14 years of Return on Sales data on file, last reported at 0.04% in Q4 2025.
- Quarterly Return on Sales rose 2.0% year-over-year to 0.04% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 0.0% (changed 0.0% YoY) and the FY2025 annual result came in at 0.0%, changed 0.0% from the prior year.
- Return on Sales advanced to 0.04% in Q4 2025, from 0.01% in the prior quarter.
- In the past five years, Return on Sales ranged from a high of 0.04% in Q4 2025 to a low of 0.02% in Q1 2021.
- A 5-year average of 0.0% and a median of 0.01% in 2023 frame the typical range for Return on Sales.
- Annual changes were most pronounced in 2021 — Return on Sales fell 3 bps — and 2023, when it increased 4 bps.
- Tracing KPTI's Return on Sales over 5 years: stood at 0.0% in 2021, then slumped by 483 bps to 0.01% in 2022, then surged by 355 bps to 0.03% in 2023, then sank by 50 bps to 0.01% in 2024, then soared by 158 bps to 0.04% in 2025.
- The last three Return on Sales figures came in at 0.04% (Q4 2025), 0.01% (Q3 2025), and 0.01% (Q2 2025), per Business Quant data.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 0.00% |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 0.00% |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | 0.00% |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | -0.05% |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 0.00% |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 0.00% |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | 0.00% |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | 0.00% |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | 0.00% |
| 10 | Karyopharm Therapeutics | 56.72 Mn | 56.72 Mn | 32.35 Mn | -0.02% |
Historic Data
Download Data| Date | Value |
|---|---|
| Jun 30, 2026 | -0.02% |
| Dec 31, 2025 | 0.04% |
| Sep 30, 2025 | -0.01% |
| Jun 30, 2025 | -0.01% |
| Mar 31, 2025 | -0.01% |
| Dec 31, 2024 | 0.01% |
| Sep 30, 2024 | -0.01% |
| Jun 30, 2024 | 0.01% |
| Mar 31, 2024 | -0.01% |
| Dec 31, 2023 | 0.03% |
| Sep 30, 2023 | -0.01% |
| Jun 30, 2023 | -0.01% |
| Mar 31, 2023 | -0.01% |
| Dec 31, 2022 | -0.01% |
| Sep 30, 2022 | -0.01% |
| Jun 30, 2022 | -0.01% |
| Mar 31, 2022 | -0.01% |
| Dec 31, 2021 | 0.00% |
| Sep 30, 2021 | -0.01% |
| Jun 30, 2021 | -0.02% |