As of August 04, 2026, Karyopharm Therapeutics's top three insider holders are Michael Kauffman (Chief Executive Officer, 1.61Mn shares), Richard A. Paulson (President And Ceo, 1.16Mn shares), Sharon Shacham (Chief Scientific Officer, 958.13K shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Garen G Bohlin | - | 45,140 | 0 | 12 Sep, 2023 |
| Barry E Greene | - | 13,606 | 0 | 15 Aug, 2022 |
| Michael Kauffman | Chief Executive Officer | 713,757 | 898,131 | 02 Mar, 2022 |
| Michael Mason | Evp, Cfo Treasurer | 398,756 | 0 | 04 Mar, 2024 |
| Sharon Shacham | Chief Scientific Officer | 958,131 | 0 | 31 Mar, 2022 |
| Ran Frenkel | Evp, Chief Dev. Officer | 168,290 | 0 | 02 Mar, 2022 |
| Stephen Mitchener | Svp, Chief Business Officer | 128,313 | 0 | 02 Mar, 2023 |
| Jatin Shah | Evp, Chief Medical Officer | 129,450 | 0 | 22 Feb, 2022 |
| Richard A. Paulson | President And Ceo | 1,164,409 | 0 | 04 Mar, 2024 |
| Reshma Rangwala | Evp Chief Medical Officer | 349,720 | 0 | 04 Mar, 2024 |
| Michael Mano | Svp, General Counselsecretary | 277,852 | 0 | 04 Mar, 2024 |
| Sohanya Roshan Cheng | Evp Chief Commercial Officer | 393,509 | 0 | 04 Mar, 2024 |
| Stuart Poulton | Evp, Chief Development Officer | 329,511 | 0 | 04 Mar, 2024 |
| Lori Macomber | Evp, Cfo Treasurer | 85,105 | 0 | 04 Feb, 2026 |
| Kristin Abate | Chief Accounting Officer | 22,063 | 0 | 03 Mar, 2026 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 21 Apr, 2026 | Reshma Rangwala | Common Stock | D | 449 | $8.94 | 56,290 | D | S |
| 21 Apr, 2026 | Reshma Rangwala | Common Stock | D | 449 | $8.94 | 56,290 | D | S |
| 21 Apr, 2026 | Reshma Rangwala | Common Stock | D | 449 | $8.94 | 56,290 | D | S |
| 02 Mar, 2026 | Richard A. Paulson | Common Stock | D | 12,361 | $9.41 | 267,030 | D | S |
| 02 Mar, 2026 | Michael Mano | Common Stock | D | 3,526 | $9.41 | 93,964 | D | S |
| 02 Mar, 2026 | Reshma Rangwala | Common Stock | D | 5,066 | $9.41 | 56,739 | D | S |
| 02 Mar, 2026 | Kristin Abate | Common Stock | D | 559 | $9.41 | 22,063 | D | S |
| 02 Mar, 2026 | Michael Mano | Common Stock | D | 3,526 | $9.41 | 93,964 | D | S |
| 02 Mar, 2026 | Reshma Rangwala | Common Stock | D | 5,066 | $9.41 | 56,739 | D | S |
| 02 Mar, 2026 | Reshma Rangwala | Common Stock | D | 5,066 | $9.41 | 56,739 | D | S |
| 02 Mar, 2026 | Stuart Poulton | Common Stock | D | 5,101 | $9.41 | 94,328 | D | S |
| 02 Mar, 2026 | Reshma Rangwala | Common Stock | D | 5,066 | $9.41 | 56,739 | D | S |
| 02 Mar, 2026 | Michael Mano | Common Stock | D | 3,526 | $9.41 | 93,964 | D | S |
| 02 Mar, 2026 | Sohanya Roshan Cheng | Common Stock | D | 4,604 | $9.41 | 107,317 | D | S |
| 02 Mar, 2026 | Stuart Poulton | Common Stock | D | 5,101 | $9.41 | 94,328 | D | S |
| 02 Mar, 2026 | Stuart Poulton | Common Stock | D | 5,101 | $9.41 | 94,328 | D | S |
| 02 Mar, 2026 | Michael Mano | Common Stock | D | 3,526 | $9.41 | 93,964 | D | S |
| 02 Mar, 2026 | Stuart Poulton | Common Stock | D | 5,101 | $9.41 | 94,328 | D | S |
| 17 Feb, 2026 | Stuart Poulton | Common Stock | D | 378 | $8.63 | 99,429 | D | S |
| 17 Feb, 2026 | Stuart Poulton | Common Stock | D | 378 | $8.63 | 99,429 | D | S |