Karyopharm Therapeutics Inc. (KPTI) Insider Ownership

Historic Insider Ownership Trends

Karyopharm Therapeutics's top three insider shareholders as of April 17, 2026 are Michael Kauffman (Chief Executive Officer, 1.61Mn shares), Richard A. Paulson (President And Ceo, 1.16Mn shares), Sharon Shacham (Chief Scientific Officer, 958.13K shares).

Top Direct Holders

Insider ownership data is derived from the last 60 months of Form 4 SEC filings.
Holder Position Shares (Direct) Shares (Indirect) Report Date
Michael Kauffman Chief Executive Officer 713,757 898,131 02 Mar, 2022
Richard A. Paulson President And Ceo 1,164,409 0 04 Mar, 2024
Sharon Shacham Chief Scientific Officer 958,131 0 31 Mar, 2022
Sharon Shacham Chief Scientific Officer 0 713,757 02 Mar, 2022
Michael Mason Evp, Cfo Treasurer 398,756 0 04 Mar, 2024
Sohanya Roshan Cheng Evp Chief Commercial Officer 393,509 0 04 Mar, 2024
Michael Mason Evp, Cfo Treasurer 391,054 0 05 Sep, 2024
Reshma Rangwala Evp Chief Medical Officer 349,720 0 04 Mar, 2024
Stuart Poulton Evp, Chief Development Officer 329,511 0 04 Mar, 2024
Michael Mano Svp, General Counselsecretary 277,852 0 04 Mar, 2024
Richard A. Paulson President And Ceo 267,030 0 03 Mar, 2026
Ran Frenkel Evp, Chief Dev. Officer 168,290 0 02 Mar, 2022
Jatin Shah Evp, Chief Medical Officer 129,450 0 22 Feb, 2022
Stephen Mitchener Svp, Chief Business Officer 128,313 0 02 Mar, 2023
Sohanya Roshan Cheng Evp Chief Commercial Officer 107,317 0 03 Mar, 2026
Stuart Poulton Evp, Chief Development Officer 94,328 0 03 Mar, 2026
Michael Mano Evp, Closecretary 93,964 0 03 Mar, 2026
Lori Macomber Evp, Cfo Treasurer 85,105 0 04 Feb, 2026
Reshma Rangwala Evp Chief Medical Officer 56,739 0 03 Mar, 2026
Garen G Bohlin - 45,140 0 12 Sep, 2023
Kristin Abate Chief Accounting Officer 22,063 0 03 Mar, 2026
Barry E Greene - 13,606 0 15 Aug, 2022

* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.

Recent Insider Transactions

Detailed insider trading activity based on Form 4 SEC filings.
Download Data
Transaction Date Insider Name Security Class Transaction Type Shares Traded Price Shares Remaining Ownership Code
02 Mar, 2026 Michael Mano Common Stock D 3,526 $9.41 93,964 D S
02 Mar, 2026 Richard A. Paulson Common Stock D 12,361 $9.41 267,030 D S
02 Mar, 2026 Sohanya Roshan Cheng Common Stock D 4,604 $9.41 107,317 D S
02 Mar, 2026 Kristin Abate Common Stock D 559 $9.41 22,063 D S
02 Mar, 2026 Stuart Poulton Common Stock D 5,101 $9.41 94,328 D S
02 Mar, 2026 Reshma Rangwala Common Stock D 5,066 $9.41 56,739 D S
17 Feb, 2026 Stuart Poulton Common Stock D 378 $8.63 99,429 D S
05 Feb, 2026 Richard A. Paulson Common Stock A 81,060 $0.00 279,391 D A
03 Feb, 2026 Lori Macomber Common Stock D 1,626 $6.30 85,105 D S
31 Jan, 2026 Sohanya Roshan Cheng Common Stock A 32,415 $0.00 111,921 D A
31 Jan, 2026 Michael Mano Common Stock A 32,415 $0.00 97,490 D A
31 Jan, 2026 Stuart Poulton Common Stock A 32,415 $0.00 99,807 D A
31 Jan, 2026 Lori Macomber Common Stock A 32,415 $0.00 86,731 D A
31 Jan, 2026 Reshma Rangwala Common Stock A 32,415 $0.00 61,805 D A
27 Jan, 2026 Kristin Abate Common Stock A 92 $0.00 22,672 D A
28 Jan, 2026 Kristin Abate Common Stock D 50 $7.03 22,622 D S
21 Jan, 2026 Kristin Abate Common Stock D 265 $5.96 22,580 D S
15 Oct, 2025 Sohanya Roshan Cheng Common Stock A 43,650 $0.00 79,506 D A
15 Oct, 2025 Kristin Abate Common Stock A 12,799 $0.00 22,845 D A
15 Oct, 2025 Lori Macomber Common Stock A 43,650 $0.00 54,316 D A