Karyopharm Therapeutics KPTI Institutional Ownership

NASDAQ KPTI

$1.65 -0.04 (-2.37%)

As of: Sep 10, 2026 · 10:19 AM EDT

Institutions by Trading Activity

98 Institutions

Increased 67 68.4%

Unchanged 17 17.3%

Reduced 14 14.3%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

73.33%

▼-88.22 pp QoQ

Shares Held by Institutions

21.22Mn

of 28.94Mn outstanding

▲+49.87% QoQ

Shares Outstanding

28.94Mn

7.72Mn held outside 13F filers

Institutional Investors

filed 13F for Jun 2026

▲+21 vs prior quarter

Net Shares Added (QoQ)

+7.06Mn

accumulated since last quarter

Value of Holdings

$37.98Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Quarter ending 30 Jun, 2026

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) appears in 98 institutional 13F filings for the quarter ending June 2026.

These investors held 73.3% of outstanding shares in June 2026, down from 161.6% in March 2026.
Their total shares held in KPTI increased 49.87% from the prior quarter, while the number of investors in Karyopharm Therapeutics increased 96.0% year over year.
During the quarter, 67 of these 98 funds increased positions in KPTI, 14 reduced exposure, and 17 held steady.
The aggregate institutional position in Karyopharm Therapeutics amounted to 21.22Mn shares as of June 2026, up by 7.06Mn shares quarter on quarter, and up 17.02Mn shares year over year.
As of June 30, 2026, the biggest holder of Karyopharm Therapeutics is RA CAPITAL MANAGEMENT, L.P. at 1.92Mn shares, representing 6.63% of shares outstanding.
Leading buyers of Karyopharm Therapeutics shares for the quarter ending June 2026 were ACORN CAPITAL ADVISORS, LLC (1.23Mn), BlackRock, Inc. (1.17Mn), Kalehua Capital Management LLC (685.64K), NEA Management Company, LLC (576.78K), TWO SIGMA INVESTMENTS, LP (544.03K).
The largest sellers of Karyopharm Therapeutics for the quarter ending June 2026 were T. Rowe Price Investment Management, Inc. (755.78K), ADAGE CAPITAL PARTNERS GP, L.L.C. (285.0K), Affinity Asset Advisors, LLC (187.5K), Jump Financial, LLC (168.15K), MILLENNIUM MANAGEMENT LLC (114.9K).
Per Business Quant, the top 10 investors in KPTI for the quarter ending June 2026 include RA CAPITAL MANAGEMENT, L.P. (1.92Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (1.52Mn), ACORN CAPITAL ADVISORS, LLC (1.52Mn), Goldman Sachs Group Inc (1.42Mn), BlackRock, Inc. (1.42Mn), VANGUARD CAPITAL MANAGEMENT LLC (958.98K), Catalio Capital Management, LP (940.86K), Avidity Partners Management LP (924.49K), T. Rowe Price Investment Management, Inc. (786.31K), TWO SIGMA INVESTMENTS, LP (695.26K).

Form 13F Holdings

98 Institutional Holders

Report period 30 Jun, 2026

Total shares held 21.22Mn

Of outstanding 73.33%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	RA CAPITAL MANAGEMENT, L.P.	0001346824	1,917,354	6.63%	0	0.00%	$18.73Mn
2	ADAGE CAPITAL PARTNERS GP, L.L.C.	0001165408	1,521,322	5.26%	▼285,000	-15.78%	$14.86Mn
3	ACORN CAPITAL ADVISORS, LLC	0002054410	1,518,113	5.25%	▲1,230,287	+427.44%	$14.83Mn
4	Goldman Sachs Group Inc	0000886982	1,424,658	4.92%	▲477,079	+50.35%	$13.92Mn
5	BlackRock, Inc.	0002012383	1,418,799	4.90%	▲1,173,900	+479.34%	$13.86Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	958,979	3.31%	▲219,234	+29.64%	$9.37Mn
7	Catalio Capital Management, LP	0001958125	940,855	3.25%	▲43,146	+4.81%	$9.19Mn
8	Avidity Partners Management LP	0001791827	924,487	3.19%	▲460,746	+99.35%	$9.03Mn
9	T. Rowe Price Investment Management, Inc.	0001897612	786,309	2.72%	▼755,781	-49.01%	$7.68K
10	TWO SIGMA INVESTMENTS, LP	0001179392	695,264	2.40%	▲544,032	+359.73%	$6.79Mn
11	Kalehua Capital Management LLC	0002106181	685,644	2.37%	▲685,644	0.00%	$6.70Mn
12	NEA Management Company, LLC	0001512848	576,780	1.99%	▲576,780	0.00%	$5.64Mn
13	GEODE CAPITAL MANAGEMENT, LLC	0001214717	531,231	1.84%	▲325,098	+157.71%	$5.19Mn
14	Ghisallo Capital Management LLC	0001825214	500,000	1.73%	▲500,000	0.00%	$4.89Mn
15	Soleus Capital Management, L.P.	0001802630	440,000	1.52%	0	0.00%	$4.30Mn
16	UBS Group AG	0001610520	353,545	1.22%	▲159,528	+82.22%	$3.45Mn
17	State Street Corp	0000093751	325,991	1.13%	▲245,249	+303.74%	$3.18Mn
18	Affinity Asset Advisors, LLC	0001773195	312,500	1.08%	▼187,500	-37.50%	$3.05Mn
19	Brevan Howard Capital Management LP	0001512857	309,817	1.07%	▲97,450	+45.89%	$3.03Mn
20	MILLENNIUM MANAGEMENT LLC	0001273087	305,676	1.06%	▼114,895	-27.32%	$2.99Mn

Showing 1 to 20 of 98 holders