Karyopharm Therapeutics Inc. (KPTI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

1,102,334Shares held by institutions

$5,908,510Value of institutional holdings

48.39%Institutional ownership %

32.63%Shares Changed QoQ

48No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) appears in 68 institutional 13F filings for the quarter ending December 2025.

They owned 92.3% of outstanding stock in December 2025, up from 33.8% the prior quarter.
Their total shares held in KPTI increased 251.8% from the prior quarter, while the number of investors in Karyopharm Therapeutics stayed flat year over year.
Among the 68 funds, 47 bought more Karyopharm Therapeutics shares, 4 sold down, and 17 held their ground.
In total, institutional investors held 10.09Mn shares in Karyopharm Therapeutics as of December 2025, up by 7.22Mn shares quarter on quarter, and with no net change year over year.
As of December 31, 2025, T. Rowe Price Investment Management, Inc. held the largest stake in Karyopharm Therapeutics with 2.08Mn shares, accounting for 19.0% of total shares outstanding.
The biggest buyers of Karyopharm Therapeutics for the quarter ending December 2025 included T. Rowe Price Investment Management, Inc. (1.38Mn), Opaleye Management Inc. (930.0K), Affinity Asset Advisors, LLC (889.58K), Ikarian Capital, LLC (517.3K), Soleus Capital Management, L.P. (440.0K).
Top sellers of KPTI stock for the quarter ending December 2025 included Morgan Stanley (16.91K), RENAISSANCE TECHNOLOGIES LLC (4.8K), Citigroup Inc (512), OSAIC HOLDINGS, INC. (64).
Business Quant data shows the 10 biggest positions in Karyopharm Therapeutics as of December 2025 are held by T. Rowe Price Investment Management, Inc. (2.08Mn), Opaleye Management Inc. (930.0K), Affinity Asset Advisors, LLC (889.58K), VANGUARD GROUP INC (559.62K), Ikarian Capital, LLC (544.55K), Soleus Capital Management, L.P. (440.0K), ADAGE CAPITAL PARTNERS GP, L.L.C. (421.32K), DAVIDSON KEMPNER CAPITAL MANAGEMENT LP (310.02K), BRAIDWELL LP (303.37K), Exome Asset Management LLC (295.54K).

68 Institutional Holders

1,102,334 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	15,607	6.73%	$0.00
Opaleye Management Inc.	31 Dec, 2025	930,000	0.00%	$0.00
T. Rowe Price Investment Management, Inc.	31 Dec, 2025	1,376,325	196.34%	$0.00
Barclays Plc	31 Dec, 2025	0	0.00%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	151,397	37.09%	$0.00
Affinity Asset Advisors, LLC	31 Dec, 2025	889,575	0.00%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	1,466	0.00%	$0.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	0	0.00%	$0.00
Ikarian Capital, LLC	31 Dec, 2025	517,297	1,897.85%	$0.00
DAVIDSON KEMPNER CAPITAL MANAGEMENT LP	31 Dec, 2025	310,020	0.00%	$0.00
Soleus Capital Management, L.P.	31 Dec, 2025	440,000	0.00%	$0.00
Ameriprise Financial Inc	31 Dec, 2025	276,881	0.00%	$0.00
BRAIDWELL LP	31 Dec, 2025	303,370	0.00%	$0.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	94,445	101.24%	$0.00
Exome Asset Management LLC	31 Dec, 2025	295,541	0.00%	$0.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	148,793	0.00%	$0.00
Boxer Capital Management, LLC	31 Dec, 2025	252,536	0.00%	$0.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	112,359	317.95%	$0.00
Catalio Capital Management, LP	31 Dec, 2025	0	0.00%	$0.00
BOOTHBAY FUND MANAGEMENT, LLC	31 Dec, 2025	144,628	0.00%	$0.00

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