Karyopharm Therapeutics Inc. (KPTI) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

10,935,000Shares Outstanding

10,091,950Shares held by institutions

$87,497,207Value of institutional holdings

92.29%Institutional ownership %

251.32%Shares Changed QoQ

68No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Karyopharm Therapeutics Inc. (NASDAQ:KPTI) has 68 institutional investors that have filed 13F reports for the period ending December 2025.

Collectively, these holders controlled 92.3% of Karyopharm Therapeutics's outstanding shares in December 2025, up from 33.8% in September 2025.
Their total shares held in KPTI increased 251.8% from the prior quarter, while the number of investors in Karyopharm Therapeutics stayed flat year over year.
Of these 68 funds, 47 grew their exposure to Karyopharm Therapeutics, 4 cut back, and 17 maintained positions.
The aggregate institutional position in Karyopharm Therapeutics amounted to 10.09Mn shares as of December 2025, up by 7.22Mn shares quarter on quarter, and with no net change year over year.
T. Rowe Price Investment Management, Inc. holds the largest position in KPTI at 2.08Mn shares as of December 31, 2025, or 19.0% of shares outstanding.
The biggest buyers of Karyopharm Therapeutics for the quarter ending December 2025 included T. Rowe Price Investment Management, Inc. (1.38Mn), Opaleye Management Inc. (930.0K), Affinity Asset Advisors, LLC (889.58K), Ikarian Capital, LLC (517.3K), Soleus Capital Management, L.P. (440.0K).
The largest sales of KPTI for the quarter ending December 2025 came from Morgan Stanley (16.91K), RENAISSANCE TECHNOLOGIES LLC (4.8K), Barclays Plc (4.11K), Citigroup Inc (512), OSAIC HOLDINGS, INC. (64).
Per Business Quant, the top 10 investors in KPTI for the quarter ending December 2025 include T. Rowe Price Investment Management, Inc. (2.08Mn), Opaleye Management Inc. (930.0K), Affinity Asset Advisors, LLC (889.58K), VANGUARD GROUP INC (559.62K), Ikarian Capital, LLC (544.55K), Soleus Capital Management, L.P. (440.0K), ADAGE CAPITAL PARTNERS GP, L.L.C. (421.32K), DAVIDSON KEMPNER CAPITAL MANAGEMENT LP (310.02K), BRAIDWELL LP (303.37K), Exome Asset Management LLC (295.54K).

68 Institutional Holders

10,091,950 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
T. Rowe Price Investment Management, Inc.	31 Dec, 2025	2,077,317	1,376,325	196.34%	$15,290.00
Opaleye Management Inc.	31 Dec, 2025	930,000	930,000	0.00%	$6,844,800.00
Affinity Asset Advisors, LLC	31 Dec, 2025	889,575	889,575	0.00%	$6,547,272.00
VANGUARD GROUP INC	31 Dec, 2025	559,619	151,397	37.09%	$4,118,796.00
Ikarian Capital, LLC	31 Dec, 2025	544,554	517,297	1,897.85%	$4,007,918.00
Soleus Capital Management, L.P.	31 Dec, 2025	440,000	440,000	0.00%	$3,238,400.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	421,322	0	0.00%	$3,100,930.00
DAVIDSON KEMPNER CAPITAL MANAGEMENT LP	31 Dec, 2025	310,020	310,020	0.00%	$2,281,747.00
BRAIDWELL LP	31 Dec, 2025	303,370	303,370	0.00%	$2,232,803.00
Exome Asset Management LLC	31 Dec, 2025	295,541	295,541	0.00%	$2,175,182.00
Ameriprise Financial Inc	31 Dec, 2025	276,881	276,881	0.00%	$2,037,844.00
Boxer Capital Management, LLC	31 Dec, 2025	252,536	252,536	0.00%	$1,858,665.00
BlackRock, Inc.	31 Dec, 2025	247,558	15,607	6.73%	$1,822,026.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	187,734	94,445	101.24%	$1,381,872.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	148,793	148,793	0.00%	$1,095,116.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	147,698	112,359	317.95%	$1,087,057.00
BOOTHBAY FUND MANAGEMENT, LLC	31 Dec, 2025	144,628	144,628	0.00%	$1,064,462.00
Catalio Capital Management, LP	31 Dec, 2025	142,984	0	0.00%	$1,052,362.00
Avidity Partners Management LP	31 Dec, 2025	134,566	0	0.00%	$990,406.00
MARSHALL WACE, LLP	31 Dec, 2025	128,451	0	0.00%	$945,400.00

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