Inovio Pharmaceuticals (INO) Return on Sales (2010 - 2025)
Inovio Pharmaceuticals (INO) posted Return on Sales of 15.1% for Q4 2025, down 172.18% sequentially from 5.55% in Q3 2025, and down 1343.0% YoY from 1.22% in Q4 2024.
Inovio Pharmaceuticals (INO) Return on Sales (2010 - 2025) Analysis & Trends
Inovio Pharmaceuticals has reported Return on Sales for 16 years, with the latest figure at 15.1% in Q4 2025.
- Quarterly Return on Sales fell 1343.0% year-over-year to 15.1% in Q4 2025, while the trailing twelve-month figure through Dec 2025 was 15.1% (down 1000.0% YoY) and the FY2025 annual result came in at 70.84%, down 4986.0% from the prior year.
- Return on Sales eased to 15.1% in Q4 2025 per INO's latest filing, from 5.55% in the prior quarter.
- Over five years, Return on Sales peaked at 0.04% in Q3 2022 and troughed at 15.1% in Q4 2025.
- A 5-year average of 3.53% and a median of 2.72% in 2021 frame the typical range for Return on Sales.
- The sharpest annual moves came in 2022 and 2025: Return on Sales jumped 202 bps in 2022, then plunged 1343 bps in 2025.
- Over 5 years, Return on Sales stood at 1.27% in 2021, then plunged by 243 bps to 4.37% in 2022, then jumped by 44 bps to 2.44% in 2023, then surged by 32 bps to 1.67% in 2024, then sank by 805 bps to 15.1% in 2025.
- According to Business Quant data, Return on Sales over the past three periods registered 15.1%, 5.55%, and 5.85% for Q4 2025, Q3 2025, and Q2 2025 respectively.
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Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Vertex Pharmaceuticals | 139.13 Bn | 131.28 Bn | 2.84 Bn | 0.00% |
| 2 | Regeneron Pharmaceuticals | 85.77 Bn | 77.77 Bn | 3.93 Bn | 0.00% |
| 3 | Argenx Se | 64.64 Bn | 59.46 Bn | 1.37 Bn | 0.00% |
| 4 | Moderna | 58.29 Bn | 53.16 Bn | 52.00 Mn | -0.05% |
| 5 | BeOne Medicines | 41.92 Bn | 36.82 Bn | 1.53 Bn | 0.00% |
| 6 | Alnylam Pharmaceuticals | 31.58 Bn | 28.28 Bn | 992.69 Mn | 0.00% |
| 7 | BioNTech SE | 28.12 Bn | 9.73 Bn | 668.28 Mn | 0.00% |
| 8 | Insmed | 27.39 Bn | 26.22 Bn | 358.27 Mn | 0.00% |
| 9 | Royalty Pharma | 27.27 Bn | 26.43 Bn | - | 0.00% |
| 10 | Inovio Pharmaceuticals | 96.32 Mn | 96.32 Mn | - | - |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -15.10% |
| Sep 30, 2025 | -5.55% |
| Jun 30, 2025 | -5.85% |
| Mar 31, 2025 | -5.80% |
| Dec 31, 2024 | -1.67% |
| Sep 30, 2024 | -5.73% |
| Jun 30, 2024 | -3.30% |
| Mar 31, 2024 | -1.76% |
| Dec 31, 2023 | -2.44% |
| Sep 30, 2023 | -0.87% |
| Jun 30, 2023 | -1.57% |
| Mar 31, 2023 | -3.54% |
| Dec 31, 2022 | -4.37% |
| Sep 30, 2022 | -0.04% |
| Jun 30, 2022 | -1.38% |
| Mar 31, 2022 | -3.86% |
| Dec 31, 2021 | -1.27% |
| Sep 30, 2021 | -2.06% |
| Jun 30, 2021 | -3.01% |
| Mar 31, 2021 | -1.45% |