Denali Therapeutics (DNLI) Return on Equity [ROE] (2018 - 2026)
Denali Therapeutics (DNLI) posted Return on Equity [ROE] of -57.71% for Q3 2026, down 6.65 percentage points from -51.06% a year earlier but up 0.35 percentage points from the prior quarter.
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Analysis
Denali Therapeutics (DNLI) Return on Equity [ROE] (2018 - 2026) Analysis & Trends
For FY2025, Denali Therapeutics' Return on Equity [ROE] came in at -45.69%, down 8.29 percentage points from FY2024.
- Annual Return on Equity [ROE] shows a five-year change of -54.90 percentage points (FY2020 to FY2025).
- In prior years, Denali Therapeutics' Return on Equity [ROE] was -37.40% in FY2024 (-23.39 pp), -14.01% in FY2023 (+18.51 pp), -32.52% in FY2022 (-5.02 pp) and -27.51% in FY2021 (-36.71 pp).
- Quarterly Return on Equity [ROE] has run from a low of -58.07% in Q2 2026 to a high of -10.80% in Q3 2023 over five years.
- On a year-over-year basis, Return on Equity [ROE] has declined in each of the last ten quarters, with an average year-over-year change of -16.91 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Return on Equity [ROE] in the past five years was Q1 2024, with a gain of 25.85 percentage points; the weakest was Q3 2022, with a drop of 38.67 percentage points.
- According to Business Quant data, Return on Equity [ROE] for the three prior quarters was -58.07% (Q2 2026), -52.37% (Q1 2026) and -52.83% (Q4 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 74.39% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 19.33% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | - |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 5.63% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 21.60% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 72.13% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -31.17% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 4.66% |
| 10 | Denali Therapeutics | 3.18 Bn | 98.89 Mn | 17.59 Mn | -58.07% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -58.07% |
| Jun 30, 2026 | -58.41% |
| Mar 31, 2026 | -52.66% |
| Dec 31, 2025 | -52.98% |
| Sep 30, 2025 | -51.52% |
| Jun 30, 2025 | -44.23% |
| Mar 31, 2025 | -38.31% |
| Dec 31, 2024 | -33.07% |
| Sep 30, 2024 | -8.77% |
| Jun 30, 2024 | -8.32% |
| Mar 31, 2024 | 13.32% |
| Dec 31, 2023 | 15.25% |
| Sep 30, 2023 | -9.92% |
| Jun 30, 2023 | -11.02% |
| Mar 31, 2023 | -36.22% |
| Dec 31, 2022 | -35.64% |
| Sep 30, 2022 | -37.02% |
| Jun 30, 2022 | -32.82% |
| Mar 31, 2022 | -31.36% |
| Dec 31, 2021 | -29.66% |
API Access
Denali Therapeutics Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "DNLI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();