Denali Therapeutics (DNLI) Return on Equity [ROE] (2018 - 2026)
Denali Therapeutics (DNLI) posted Return on Equity [ROE] of -58.07% for Q2 2026, down 13.51 percentage points from -44.56% a year earlier and down 5.70 percentage points from the prior quarter.
Powered by 
Analysis
Denali Therapeutics (DNLI) Return on Equity [ROE] (2018 - 2026) Analysis & Trends
For FY2025, Denali Therapeutics' Return on Equity [ROE] came in at -45.69%, down 8.29 percentage points from FY2024.
- Annual Return on Equity [ROE] shows a five-year change of -54.90 percentage points (FY2020 to FY2025).
- In prior years, Denali Therapeutics' Return on Equity [ROE] was -37.40% in FY2024 (-23.39 pp), -14.01% in FY2023 (+18.51 pp), -32.52% in FY2022 (-5.02 pp) and -27.51% in FY2021 (-36.71 pp).
- The Q2 2026 figure stands as the lowest quarterly Return on Equity [ROE] in data going back to Q1 2018.
- On a year-over-year basis, Return on Equity [ROE] has declined in each of the last nine quarters, with an average year-over-year change of -18.68 percentage points over the last eight quarters.
- The strongest year-over-year quarter for Return on Equity [ROE] in the past five years was Q3 2021, with a gain of 35.73 percentage points; the weakest was Q3 2022, with a drop of 38.67 percentage points.
- According to Business Quant data, Return on Equity [ROE] for the three prior quarters was -52.37% (Q1 2026), -52.83% (Q4 2025) and -51.06% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROE (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 25.32% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | - |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 7.21% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 84.40% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 21.39% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 83.75% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -18.38% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 4.97% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 22.24% |
| 10 | Denali Therapeutics | 3.30 Bn | 3.30 Bn | 3.51 Mn | -58.07% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -58.07% |
| Mar 31, 2026 | -52.37% |
| Dec 31, 2025 | -52.83% |
| Sep 30, 2025 | -51.06% |
| Jun 30, 2025 | -44.56% |
| Mar 31, 2025 | -38.59% |
| Dec 31, 2024 | -33.18% |
| Sep 30, 2024 | -31.60% |
| Jun 30, 2024 | -29.53% |
| Mar 31, 2024 | -11.04% |
| Dec 31, 2023 | -13.51% |
| Sep 30, 2023 | -10.80% |
| Jun 30, 2023 | -11.92% |
| Mar 31, 2023 | -36.89% |
| Dec 31, 2022 | -35.31% |
| Sep 30, 2022 | -35.84% |
| Jun 30, 2022 | -31.64% |
| Mar 31, 2022 | -30.53% |
| Dec 31, 2021 | -29.43% |
| Sep 30, 2021 | 2.84% |
API Access
Denali Therapeutics Return on Equity [ROE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-equity-[roe]", "ticker": "DNLI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-equity-%5Broe%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();