Denali Therapeutics (DNLI) Return on Capital Employed [ROCE] (2018 - 2026)
Denali Therapeutics (DNLI) recorded Return on Capital Employed [ROCE] of -47.85% in Q3 2026, up 5.81 percentage points from -53.67% a year earlier and up 0.52 percentage points from the prior quarter.
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Analysis
Denali Therapeutics (DNLI) Return on Capital Employed [ROCE] (2018 - 2026) Analysis & Trends
For FY2025, Denali Therapeutics reported Return on Capital Employed [ROCE] of -47.83%, down 5.88 percentage points from FY2024.
- Annual Return on Capital Employed [ROCE] has a five-year change of -54.05 percentage points (FY2020 to FY2025).
- Across earlier years, Return on Capital Employed [ROCE] came in at -41.95% in FY2024 (-25.94 pp), -16.00% in FY2023 (+15.89 pp), -31.90% in FY2022 (-5.63 pp) and -26.27% in FY2021 (-32.49 pp).
- The Q3 2026 figure is the highest quarterly Return on Capital Employed [ROCE] since Q2 2025.
- On a year-over-year basis, Return on Capital Employed [ROCE] rose in 1 of the last eight quarters, with an average year-over-year change of -12.62 percentage points.
- Peak year-over-year performance for Return on Capital Employed [ROCE] in the last five years was a gain of 22.78 percentage points in Q1 2024, against a drop of 36.53 percentage points in Q3 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -48.37% (Q2 2026), -49.95% (Q1 2026) and -55.43% (Q4 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,348.13 Bn | 1,321.74 Bn | 20.46 Bn | 35.41% |
| 2 | Johnson & Johnson | 675.90 Bn | 595.76 Bn | 17.30 Bn | 17.52% |
| 3 | AbbVie | 519.45 Bn | 487.50 Bn | 13.12 Bn | 21.60% |
| 4 | Merck | 364.95 Bn | 327.95 Bn | 13.19 Bn | 4.65% |
| 5 | Novartis Ag | 311.58 Bn | 285.16 Bn | - | - |
| 6 | Astrazeneca | 289.34 Bn | 262.94 Bn | 13.26 Bn | 9.91% |
| 7 | Amgen | 251.64 Bn | 203.30 Bn | 7.58 Bn | 17.37% |
| 8 | Gilead Sciences | 212.05 Bn | 187.07 Bn | 6.73 Bn | -6.15% |
| 9 | Pfizer | 167.35 Bn | 115.00 Bn | 12.56 Bn | 11.32% |
| 10 | Denali Therapeutics | 3.18 Bn | 98.89 Mn | 17.59 Mn | -47.85% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Sep 30, 2026 | -47.85% |
| Jun 30, 2026 | -48.37% |
| Mar 31, 2026 | -49.95% |
| Dec 31, 2025 | -55.43% |
| Sep 30, 2025 | -53.67% |
| Jun 30, 2025 | -47.31% |
| Mar 31, 2025 | -41.86% |
| Dec 31, 2024 | -37.15% |
| Sep 30, 2024 | -35.23% |
| Jun 30, 2024 | -32.76% |
| Mar 31, 2024 | -15.07% |
| Dec 31, 2023 | -17.60% |
| Sep 30, 2023 | -14.12% |
| Jun 30, 2023 | -12.67% |
| Mar 31, 2023 | -37.85% |
| Dec 31, 2022 | -34.77% |
| Sep 30, 2022 | -34.75% |
| Jun 30, 2022 | -30.32% |
| Mar 31, 2022 | -28.50% |
| Dec 31, 2021 | -28.20% |
API Access
Denali Therapeutics Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "DNLI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();