Denali Therapeutics (DNLI) Return on Capital Employed [ROCE] (2018 - 2026)
Denali Therapeutics (DNLI) recorded Return on Capital Employed [ROCE] of -48.37% in Q2 2026, down 1.06 percentage points from -47.31% a year earlier but up 1.58 percentage points from the prior quarter.
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Analysis
Denali Therapeutics (DNLI) Return on Capital Employed [ROCE] (2018 - 2026) Analysis & Trends
For FY2025, Denali Therapeutics reported Return on Capital Employed [ROCE] of -47.83%, down 5.88 percentage points from FY2024.
- Annual Return on Capital Employed [ROCE] has a five-year change of -54.05 percentage points (FY2020 to FY2025).
- Across earlier years, Return on Capital Employed [ROCE] came in at -41.95% in FY2024 (-25.94 pp), -16.00% in FY2023 (+15.89 pp), -31.90% in FY2022 (-5.63 pp) and -26.27% in FY2021 (-32.49 pp).
- Quarterly Return on Capital Employed [ROCE] has ranged from -55.43% in Q4 2025 to 1.79% in Q3 2021 over the past five years.
- On a year-over-year basis, Return on Capital Employed [ROCE] has declined for nine consecutive quarters, with an average year-over-year change of -15.98 percentage points over the last eight quarters.
- Peak year-over-year performance for Return on Capital Employed [ROCE] in the last five years was a gain of 33.52 percentage points in Q3 2021, against a drop of 36.53 percentage points in Q3 2022 at the low end.
- Per Business Quant, the preceding three quarters came in at -49.95% (Q1 2026), -55.43% (Q4 2025) and -53.67% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROCE (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,082.65 Bn | 1,051.23 Bn | 19.71 Bn | 46.74% |
| 2 | Johnson & Johnson | 623.68 Bn | 542.21 Bn | 17.26 Bn | 17.83% |
| 3 | AbbVie | 459.43 Bn | 432.59 Bn | 12.70 Bn | 17.92% |
| 4 | Merck | 354.80 Bn | 309.23 Bn | 12.21 Bn | 6.28% |
| 5 | Novartis Ag | 269.16 Bn | 225.03 Bn | 11.24 Bn | 19.32% |
| 6 | Astrazeneca | 244.40 Bn | 217.97 Bn | 12.86 Bn | 9.54% |
| 7 | Amgen | 220.17 Bn | 175.57 Bn | 7.24 Bn | 16.66% |
| 8 | Gilead Sciences | 183.05 Bn | 157.16 Bn | 6.22 Bn | -5.97% |
| 9 | Pfizer | 160.27 Bn | 107.22 Bn | 10.94 Bn | 11.86% |
| 10 | Denali Therapeutics | 3.28 Bn | 3.28 Bn | 3.51 Mn | -48.37% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -48.37% |
| Mar 31, 2026 | -49.95% |
| Dec 31, 2025 | -55.43% |
| Sep 30, 2025 | -53.67% |
| Jun 30, 2025 | -47.31% |
| Mar 31, 2025 | -41.86% |
| Dec 31, 2024 | -37.15% |
| Sep 30, 2024 | -35.23% |
| Jun 30, 2024 | -32.76% |
| Mar 31, 2024 | -15.07% |
| Dec 31, 2023 | -17.60% |
| Sep 30, 2023 | -14.12% |
| Jun 30, 2023 | -12.67% |
| Mar 31, 2023 | -37.85% |
| Dec 31, 2022 | -34.77% |
| Sep 30, 2022 | -34.75% |
| Jun 30, 2022 | -30.32% |
| Mar 31, 2022 | -28.50% |
| Dec 31, 2021 | -28.20% |
| Sep 30, 2021 | 1.79% |
API Access
Denali Therapeutics Return on Capital Employed [ROCE] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-capital-employed-[roce]", "ticker": "DNLI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-capital-employed-%5Broce%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();