Denali Therapeutics (DNLI) Return on Assets [ROA] (2018 - 2026)
Denali Therapeutics' Return on Assets [ROA] was -42.19% in Q2 2026, down 2.89 percentage points from -39.30% a year earlier and down 0.06 percentage points from the prior quarter.
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Analysis
Denali Therapeutics (DNLI) Return on Assets [ROA] (2018 - 2026) Analysis & Trends
For FY2025, Return on Assets [ROA] at Denali Therapeutics came in at -40.69%, down 7.25 percentage points from FY2024.
- Return on Assets [ROA] shows a five-year change of -47.29 percentage points (FY2020 to FY2025).
- In earlier years, Return on Assets [ROA] was -33.45% in FY2024 (-22.34 pp), -11.11% in FY2023 (+11.65 pp), -22.76% in FY2022 (-3.44 pp) and -19.32% in FY2021 (-25.91 pp).
- Quarterly Return on Assets [ROA] has moved between -46.58% (Q4 2025) and 2.00% (Q3 2021) over five years.
- Compared with a year earlier, Return on Assets [ROA] has declined for nine straight quarters, with an average year-over-year change of -14.57 percentage points over the last eight quarters.
- The best year-over-year quarter for Return on Assets [ROA] over five years was Q3 2021 (a gain of 28.52 percentage points); the worst was Q3 2022 (a drop of 26.11 percentage points).
- Per Business Quant data, DNLI's Return on Assets [ROA] in the three quarters before Q2 2026 was -42.14% (Q1 2026), -46.58% (Q4 2025) and -44.89% (Q3 2025).
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROA (Qtr) |
|---|---|---|---|---|---|
| 1 | Johnson & Johnson | 638.12 Bn | 556.64 Bn | 17.26 Bn | 10.47% |
| 2 | AbbVie | 462.60 Bn | 435.75 Bn | 12.70 Bn | 4.65% |
| 3 | Merck | 358.70 Bn | 313.13 Bn | 12.21 Bn | 2.45% |
| 4 | Novartis Ag | 272.16 Bn | 228.03 Bn | 11.24 Bn | 28.37% |
| 5 | Astrazeneca | 250.36 Bn | 223.92 Bn | 12.86 Bn | 9.10% |
| 6 | Amgen | 227.87 Bn | 183.27 Bn | 7.24 Bn | 9.29% |
| 7 | Gilead Sciences | 184.97 Bn | 159.08 Bn | 6.22 Bn | -6.13% |
| 8 | Pfizer | 162.61 Bn | 109.56 Bn | 10.94 Bn | 2.14% |
| 9 | Vertex Pharmaceuticals | 132.45 Bn | 104.46 Bn | 2.84 Bn | 16.34% |
| 10 | Denali Therapeutics | 3.30 Bn | 3.30 Bn | 3.51 Mn | -42.19% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Jun 30, 2026 | -42.19% |
| Mar 31, 2026 | -42.14% |
| Dec 31, 2025 | -46.58% |
| Sep 30, 2025 | -44.89% |
| Jun 30, 2025 | -39.30% |
| Mar 31, 2025 | -34.31% |
| Dec 31, 2024 | -29.89% |
| Sep 30, 2024 | -28.92% |
| Jun 30, 2024 | -27.22% |
| Mar 31, 2024 | -10.04% |
| Dec 31, 2023 | -12.15% |
| Sep 30, 2023 | -9.79% |
| Jun 30, 2023 | -9.46% |
| Mar 31, 2023 | -25.83% |
| Dec 31, 2022 | -24.35% |
| Sep 30, 2022 | -24.11% |
| Jun 30, 2022 | -21.82% |
| Mar 31, 2022 | -21.07% |
| Dec 31, 2021 | -20.36% |
| Sep 30, 2021 | 2.00% |
API Access
Denali Therapeutics Return on Assets [ROA] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-assets-[roa]", "ticker": "DNLI", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-assets-%5Broa%5D&ticker=DNLI&period=max&api_key=YOUR_API_KEY");
const data = await res.json();