Denali Therapeutics (DNLI) Research & Development (2017 - 2026)

Denali Therapeutics' (DNLI) quarterly Research & Development came in at $103.8 million in Q1 2026, down 10.65% year-on-year from $116.2 million in Q1 2025, and up 6.07% on a QoQ basis from $97.9 million in Q4 2025.

Denali Therapeutics (DNLI) Research & Development (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has 10 years of Research & Development data on file, last reported at $103.8 million in Q1 2026.

  • On a quarterly basis, Research & Development fell 10.65% year-over-year to $103.8 million in Q1 2026; TTM through Mar 2026 was $406.4 million, a 0.18% change from a year earlier, with the FY2025 full-year figure at $418.8 million, up 5.63% from the prior year.
  • Research & Development for Q1 2026 stood at $103.8 million, up from $97.9 million in the prior quarter.
  • Over the last five years, Research & Development for DNLI reached as high as $128.8 million in Q1 2023 and fell as low as $86.1 million in Q1 2022.
  • Historically, Research & Development has averaged $100.1 million across 5 years, with a median of $98.2 million in 2024.
  • Across the five-year window, Research & Development surged 49.62% in 2023 and fell 16.92% in 2024, its largest moves.
  • Year by year, Research & Development stood at $92.1 million in 2022, then grew by 17.04% to $107.8 million in 2023, then retreated by 7.44% to $99.8 million in 2024, then declined by 1.89% to $97.9 million in 2025, then advanced by 6.07% to $103.8 million in 2026.
  • Per Business Quant data, the three most recent Research & Development figures were $103.8 million in Q1 2026, $97.9 million in Q4 2025, and $101.9 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) R&D (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -17.94 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - 1.46 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 541.22 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 961.60 Mn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 1.54 Bn
7 Belite Bio 61.40 Bn 61.40 Bn - 15.66 Mn
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -443.00 Mn
9 Revolution Medicines 37.37 Bn 37.37 Bn - 343.97 Mn
10 Denali Therapeutics 4.33 Bn 4.33 Bn - 103.85 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 103.85 Mn
Dec 31, 2025 97.91 Mn
Sep 30, 2025 101.95 Mn
Jun 30, 2025 102.70 Mn
Mar 31, 2025 116.23 Mn
Dec 31, 2024 99.79 Mn
Sep 30, 2024 98.24 Mn
Jun 30, 2024 91.40 Mn
Mar 31, 2024 107.02 Mn
Dec 31, 2023 107.80 Mn
Sep 30, 2023 89.74 Mn
Jun 30, 2023 97.52 Mn
Mar 31, 2023 128.82 Mn
Dec 31, 2022 92.11 Mn
Sep 30, 2022 87.79 Mn
Jun 30, 2022 92.74 Mn
Mar 31, 2022 86.10 Mn
Dec 31, 2021 67.88 Mn
Sep 30, 2021 71.56 Mn
Jun 30, 2021 65.71 Mn