Denali Therapeutics (DNLI) Research & Development (2017 - 2026)

Denali Therapeutics (DNLI) reported Research & Development of $103.8 million for Q1 2026, down 10.65% year-over-year from $116.2 million in Q1 2025, and up 6.07% quarter-over-quarter from $97.9 million in Q4 2025.

Denali Therapeutics (DNLI) Research & Development (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has 10 years of Research & Development data on file, last reported at $103.8 million in Q1 2026.

  • Research & Development for Q1 2026 came in at $103.8 million, down 10.65% year-over-year; the trailing twelve-month figure through Mar 2026 was $406.4 million (changed 0.18% YoY), and the FY2025 annual result was $418.8 million, up 5.63% from the prior year.
  • Research & Development advanced to $103.8 million in Q1 2026 per DNLI's latest filing, from $97.9 million in the prior quarter.
  • Over five years, Research & Development peaked at $128.8 million in Q1 2023 and troughed at $86.1 million in Q1 2022.
  • A 5-year average of $100.1 million and a median of $98.2 million in 2024 frame the typical range for Research & Development.
  • The sharpest annual moves came in 2023 and 2024: Research & Development jumped 49.62% in 2023, then decreased 16.92% in 2024.
  • A 5-year view of Research & Development shows it stood at $92.1 million in 2022, then gained by 17.04% to $107.8 million in 2023, then dropped by 7.44% to $99.8 million in 2024, then decreased by 1.89% to $97.9 million in 2025, then increased by 6.07% to $103.8 million in 2026.
  • Business Quant data shows DNLI's Research & Development at $103.8 million in Q1 2026, $97.9 million in Q4 2025, and $101.9 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) R&D (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.32 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 15.66 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 626,092.00
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -101.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -2.30 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 1.46 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 357,444.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 961.60 Mn
9 Abivax 91.96 Bn 91.96 Bn - -58.00 Mn
10 Denali Therapeutics 4.35 Bn 4.35 Bn - 103.85 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 103.85 Mn
Dec 31, 2025 97.91 Mn
Sep 30, 2025 101.95 Mn
Jun 30, 2025 102.70 Mn
Mar 31, 2025 116.23 Mn
Dec 31, 2024 99.79 Mn
Sep 30, 2024 98.24 Mn
Jun 30, 2024 91.40 Mn
Mar 31, 2024 107.02 Mn
Dec 31, 2023 107.80 Mn
Sep 30, 2023 89.74 Mn
Jun 30, 2023 97.52 Mn
Mar 31, 2023 128.82 Mn
Dec 31, 2022 92.11 Mn
Sep 30, 2022 87.79 Mn
Jun 30, 2022 92.74 Mn
Mar 31, 2022 86.10 Mn
Dec 31, 2021 67.88 Mn
Sep 30, 2021 71.56 Mn
Jun 30, 2021 65.71 Mn