Denali Therapeutics (DNLI) Research & Development (2017 - 2026)
Denali Therapeutics (DNLI) reported Research & Development of $103.8 million for Q1 2026, down 10.65% year-over-year from $116.2 million in Q1 2025, and up 6.07% quarter-over-quarter from $97.9 million in Q4 2025.
Denali Therapeutics (DNLI) Research & Development (2017 - 2026) Analysis & Trends
Denali Therapeutics (DNLI) has 10 years of Research & Development data on file, last reported at $103.8 million in Q1 2026.
- Research & Development for Q1 2026 came in at $103.8 million, down 10.65% year-over-year; the trailing twelve-month figure through Mar 2026 was $406.4 million (changed 0.18% YoY), and the FY2025 annual result was $418.8 million, up 5.63% from the prior year.
- Research & Development advanced to $103.8 million in Q1 2026 per DNLI's latest filing, from $97.9 million in the prior quarter.
- Over five years, Research & Development peaked at $128.8 million in Q1 2023 and troughed at $86.1 million in Q1 2022.
- A 5-year average of $100.1 million and a median of $98.2 million in 2024 frame the typical range for Research & Development.
- The sharpest annual moves came in 2023 and 2024: Research & Development jumped 49.62% in 2023, then decreased 16.92% in 2024.
- A 5-year view of Research & Development shows it stood at $92.1 million in 2022, then gained by 17.04% to $107.8 million in 2023, then dropped by 7.44% to $99.8 million in 2024, then decreased by 1.89% to $97.9 million in 2025, then increased by 6.07% to $103.8 million in 2026.
- Business Quant data shows DNLI's Research & Development at $103.8 million in Q1 2026, $97.9 million in Q4 2025, and $101.9 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | R&D (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 925,601.88 Bn | 925,601.85 Bn | - | 4.32 Mn |
| 2 | Belite Bio | 58,560.00 Bn | 58,560.00 Bn | - | 15.66 Mn |
| 3 | Quantum Biopharma | 17,284.41 Bn | 17,284.40 Bn | - | 626,092.00 |
| 4 | Legend Biotech | 2,809.00 Bn | 2,808.71 Bn | 242.10 Mn | -101.30 Mn |
| 5 | Evaxion A | 1,334.43 Bn | 1,334.42 Bn | - | -2.30 Mn |
| 6 | Akari Therapeutics | 1,312.27 Bn | 1,312.26 Bn | - | 1.46 Mn |
| 7 | Psyence Biomedical | 212.16 Bn | 212.16 Bn | - | 357,444.00 |
| 8 | Vertex Pharmaceuticals | 114.83 Bn | 107.58 Bn | 2.59 Bn | 961.60 Mn |
| 9 | Abivax | 91.96 Bn | 91.96 Bn | - | -58.00 Mn |
| 10 | Denali Therapeutics | 4.35 Bn | 4.35 Bn | - | 103.85 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 103.85 Mn |
| Dec 31, 2025 | 97.91 Mn |
| Sep 30, 2025 | 101.95 Mn |
| Jun 30, 2025 | 102.70 Mn |
| Mar 31, 2025 | 116.23 Mn |
| Dec 31, 2024 | 99.79 Mn |
| Sep 30, 2024 | 98.24 Mn |
| Jun 30, 2024 | 91.40 Mn |
| Mar 31, 2024 | 107.02 Mn |
| Dec 31, 2023 | 107.80 Mn |
| Sep 30, 2023 | 89.74 Mn |
| Jun 30, 2023 | 97.52 Mn |
| Mar 31, 2023 | 128.82 Mn |
| Dec 31, 2022 | 92.11 Mn |
| Sep 30, 2022 | 87.79 Mn |
| Jun 30, 2022 | 92.74 Mn |
| Mar 31, 2022 | 86.10 Mn |
| Dec 31, 2021 | 67.88 Mn |
| Sep 30, 2021 | 71.56 Mn |
| Jun 30, 2021 | 65.71 Mn |