Denali Therapeutics (DNLI) Research & Development (2017 - 2026)
Denali Therapeutics' (DNLI) quarterly Research & Development came in at $103.8 million in Q1 2026, down 10.65% year-on-year from $116.2 million in Q1 2025, and up 6.07% on a QoQ basis from $97.9 million in Q4 2025.
Denali Therapeutics (DNLI) Research & Development (2017 - 2026) Analysis & Trends
Denali Therapeutics (DNLI) has 10 years of Research & Development data on file, last reported at $103.8 million in Q1 2026.
- On a quarterly basis, Research & Development fell 10.65% year-over-year to $103.8 million in Q1 2026; TTM through Mar 2026 was $406.4 million, a 0.18% change from a year earlier, with the FY2025 full-year figure at $418.8 million, up 5.63% from the prior year.
- Research & Development for Q1 2026 stood at $103.8 million, up from $97.9 million in the prior quarter.
- Over the last five years, Research & Development for DNLI reached as high as $128.8 million in Q1 2023 and fell as low as $86.1 million in Q1 2022.
- Historically, Research & Development has averaged $100.1 million across 5 years, with a median of $98.2 million in 2024.
- Across the five-year window, Research & Development surged 49.62% in 2023 and fell 16.92% in 2024, its largest moves.
- Year by year, Research & Development stood at $92.1 million in 2022, then grew by 17.04% to $107.8 million in 2023, then retreated by 7.44% to $99.8 million in 2024, then declined by 1.89% to $97.9 million in 2025, then advanced by 6.07% to $103.8 million in 2026.
- Per Business Quant data, the three most recent Research & Development figures were $103.8 million in Q1 2026, $97.9 million in Q4 2025, and $101.9 million in Q3 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | R&D (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -17.94 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | 1.46 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 541.22 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 961.60 Mn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 1.54 Bn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | 15.66 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | -443.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | 343.97 Mn |
| 10 | Denali Therapeutics | 4.33 Bn | 4.33 Bn | - | 103.85 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | 103.85 Mn |
| Dec 31, 2025 | 97.91 Mn |
| Sep 30, 2025 | 101.95 Mn |
| Jun 30, 2025 | 102.70 Mn |
| Mar 31, 2025 | 116.23 Mn |
| Dec 31, 2024 | 99.79 Mn |
| Sep 30, 2024 | 98.24 Mn |
| Jun 30, 2024 | 91.40 Mn |
| Mar 31, 2024 | 107.02 Mn |
| Dec 31, 2023 | 107.80 Mn |
| Sep 30, 2023 | 89.74 Mn |
| Jun 30, 2023 | 97.52 Mn |
| Mar 31, 2023 | 128.82 Mn |
| Dec 31, 2022 | 92.11 Mn |
| Sep 30, 2022 | 87.79 Mn |
| Jun 30, 2022 | 92.74 Mn |
| Mar 31, 2022 | 86.10 Mn |
| Dec 31, 2021 | 67.88 Mn |
| Sep 30, 2021 | 71.56 Mn |
| Jun 30, 2021 | 65.71 Mn |