Denali Therapeutics (DNLI) Free Cash Flow (2017 - 2026)
Denali Therapeutics (DNLI) reported Free Cash Flow of -$133.7 million for Q1 2026, up 2.11% year-over-year from -$130.9 million in Q1 2025, and down 33.59% on a QoQ basis from -$100.1 million in Q4 2025.
Denali Therapeutics (DNLI) has 10 years of Free Cash Flow data on file, last reported at -$133.7 million in Q1 2026.
- Quarterly Free Cash Flow rose 2.11% year-over-year to -$133.7 million in Q1 2026, while the trailing twelve-month figure through Mar 2026 was -$419.2 million (down 13.41% YoY) and the FY2025 annual result came in at -$422.1 million, down 20.99% from the prior year.
- Free Cash Flow declined to -$133.7 million in Q1 2026 per DNLI's latest filing, from -$100.1 million in the prior quarter.
- Across five years, Free Cash Flow topped out at -$49.7 million in Q2 2022 and bottomed at -$136.5 million in Q1 2025.
- The 5-year median for Free Cash Flow is -$89.4 million (2023), against an average of -$89.5 million.
- The widest annual swing landed in 2023, when Free Cash Flow sank 132.77%; it then rose 29.53% in 2024.
- Tracing DNLI's Free Cash Flow over 5 years: stood at -$61.1 million in 2022, then plunged by 65.01% to -$100.9 million in 2023, then increased by 26.57% to -$74.1 million in 2024, then sank by 35.06% to -$100.1 million in 2025, then tumbled by 33.59% to -$133.7 million in 2026.
- Per Business Quant, the three latest DNLI Free Cash Flow figures stand at -$133.7 million (Q1 2026), -$100.1 million (Q4 2025), and -$105.9 million (Q3 2025).
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Free Cash Flow (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | -1.67 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | - |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -12.20 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | -2.49 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 1.29 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | - |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 848.30 Mn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 48.67 Mn |
| 10 | Denali Therapeutics | 3.82 Bn | 3.82 Bn | - | -133.67 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Mar 31, 2026 | -133.67 Mn |
| Mar 31, 2026 | -133.67 Mn |
| Dec 31, 2025 | -100.06 Mn |
| Dec 31, 2025 | -100.06 Mn |
| Sep 30, 2025 | -105.92 Mn |
| Sep 30, 2025 | -105.92 Mn |
| Jun 30, 2025 | -79.58 Mn |
| Jun 30, 2025 | -79.58 Mn |
| Mar 31, 2025 | -136.55 Mn |
| Mar 31, 2025 | -136.55 Mn |
| Dec 31, 2024 | -74.09 Mn |
| Dec 31, 2024 | -74.09 Mn |
| Sep 30, 2024 | -63.02 Mn |
| Sep 30, 2024 | -63.02 Mn |
| Jun 30, 2024 | -96.01 Mn |
| Jun 30, 2024 | -96.01 Mn |
| Mar 31, 2024 | -115.77 Mn |
| Mar 31, 2024 | -115.77 Mn |
| Dec 31, 2023 | -100.89 Mn |
| Dec 31, 2023 | -100.89 Mn |
| Sep 30, 2023 | -89.43 Mn |
| Sep 30, 2023 | -89.43 Mn |
| Jun 30, 2023 | -115.73 Mn |
| Jun 30, 2023 | -115.73 Mn |
| Mar 31, 2023 | -64.88 Mn |
| Mar 31, 2023 | -64.88 Mn |
| Dec 31, 2022 | -61.14 Mn |
| Dec 31, 2022 | -61.14 Mn |
| Sep 30, 2022 | -63.10 Mn |
| Sep 30, 2022 | -63.10 Mn |
| Jun 30, 2022 | -49.72 Mn |
| Jun 30, 2022 | -49.72 Mn |
| Mar 31, 2022 | -72.22 Mn |
| Mar 31, 2022 | -72.22 Mn |
| Dec 31, 2021 | -73.97 Mn |
| Dec 31, 2021 | -73.97 Mn |
| Sep 30, 2021 | -41.23 Mn |
| Sep 30, 2021 | -41.23 Mn |
| Jun 30, 2021 | -54.45 Mn |
| Jun 30, 2021 | -54.45 Mn |
| Mar 31, 2021 | -50.24 Mn |
| Mar 31, 2021 | -50.24 Mn |
| Dec 31, 2020 | 512.72 Mn |
| Dec 31, 2020 | 512.72 Mn |
| Sep 30, 2020 | -1.81 Mn |
| Sep 30, 2020 | -1.81 Mn |
| Jun 30, 2020 | -42.48 Mn |
| Jun 30, 2020 | -42.48 Mn |
| Mar 31, 2020 | -55.37 Mn |
| Mar 31, 2020 | -55.37 Mn |
| Sep 30, 2019 | -119.08 Mn |
| Sep 30, 2019 | -119.08 Mn |
| Jun 30, 2019 | -53.91 Mn |
| Jun 30, 2019 | -53.91 Mn |
| Mar 31, 2019 | -31.89 Mn |
| Mar 31, 2019 | -31.89 Mn |
| Dec 31, 2018 | 89.83 Mn |
| Dec 31, 2018 | 89.83 Mn |
| Sep 30, 2018 | -33.75 Mn |
| Sep 30, 2018 | -33.75 Mn |
| Jun 30, 2018 | -42.40 Mn |
| Jun 30, 2018 | -42.40 Mn |
| Mar 31, 2018 | 33.04 Mn |
| Mar 31, 2018 | 33.04 Mn |
| Dec 31, 2017 | -21.13 Mn |
| Dec 31, 2017 | -21.13 Mn |
| Sep 30, 2017 | -20.56 Mn |
| Sep 30, 2017 | -20.56 Mn |
| Jun 30, 2017 | -18.14 Mn |
| Jun 30, 2017 | -18.14 Mn |
| Mar 31, 2017 | -19.68 Mn |
| Mar 31, 2017 | -19.68 Mn |