Denali Therapeutics (DNLI) Free Cash Flow (2017 - 2026)

Denali Therapeutics' (DNLI) quarterly Free Cash Flow came in at -$133.7 million in Q1 2026, up 2.11% year-on-year from -$130.9 million in Q1 2025, and down 22.25% on a QoQ basis from -$109.3 million in Q4 2025.

Denali Therapeutics (DNLI) Free Cash Flow (2017 - 2026) Analysis & Trends

Denali Therapeutics (DNLI) has 10 years of Free Cash Flow data on file, last reported at -$133.7 million in Q1 2026.

  • On a quarterly basis, Free Cash Flow rose 2.11% year-over-year to -$133.7 million in Q1 2026; TTM through Mar 2026 was -$419.2 million, a 13.41% decrease from a year earlier, with the FY2025 full-year figure at -$422.1 million, down 20.99% from the prior year.
  • Free Cash Flow for Q1 2026 stood at -$133.7 million, down from -$109.3 million in the prior quarter.
  • Over the last five years, Free Cash Flow for DNLI reached as high as -$49.7 million in Q2 2022 and fell as low as -$136.5 million in Q1 2025.
  • Historically, Free Cash Flow has averaged -$89.4 million across 5 years, with a median of -$83.7 million in 2024.
  • Across the five-year window, Free Cash Flow sank 132.77% in 2023 and soared 32.19% in 2024, its largest moves.
  • Year by year, Free Cash Flow stood at -$72.4 million in 2022, then tumbled by 54.18% to -$111.6 million in 2023, then gained by 24.97% to -$83.7 million in 2024, then tumbled by 30.59% to -$109.3 million in 2025, then dropped by 22.25% to -$133.7 million in 2026.
  • Per Business Quant data, the three most recent Free Cash Flow figures were -$133.7 million in Q1 2026, -$109.3 million in Q4 2025, and -$96.6 million in Q3 2025.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Free Cash Flow (Qtr)
1 Oculis Holding AG 67,072.09 Bn 67,072.09 Bn - -19.58 Mn
2 Nanobiotix 1,894.61 Bn 1,894.55 Bn - -
3 Akari Therapeutics 1,014.18 Bn 1,014.18 Bn - -2.49 Mn
4 BeOne Medicines 471.64 Bn 466.85 Bn 1.35 Bn 158.09 Mn
5 Vertex Pharmaceuticals 121.72 Bn 114.47 Bn 2.59 Bn 1.29 Bn
6 Regeneron Pharmaceuticals 68.28 Bn 59.52 Bn 3.31 Bn 848.30 Mn
7 Belite Bio 61.40 Bn 61.40 Bn - -
8 Argenx Se 56.94 Bn 56.94 Bn 1.18 Bn -
9 Revolution Medicines 37.37 Bn 37.37 Bn - -354.95 Mn
10 Denali Therapeutics 4.33 Bn 4.33 Bn - -133.67 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -133.67 Mn
Mar 31, 2026 -133.67 Mn
Dec 31, 2025 -109.35 Mn
Dec 31, 2025 -109.35 Mn
Sep 30, 2025 -96.64 Mn
Sep 30, 2025 -96.64 Mn
Jun 30, 2025 -79.58 Mn
Jun 30, 2025 -79.58 Mn
Mar 31, 2025 -136.55 Mn
Mar 31, 2025 -136.55 Mn
Dec 31, 2024 -83.73 Mn
Dec 31, 2024 -83.73 Mn
Sep 30, 2024 -53.38 Mn
Sep 30, 2024 -53.38 Mn
Jun 30, 2024 -96.01 Mn
Jun 30, 2024 -96.01 Mn
Mar 31, 2024 -115.77 Mn
Mar 31, 2024 -115.77 Mn
Dec 31, 2023 -111.60 Mn
Dec 31, 2023 -111.60 Mn