Denali Therapeutics (DNLI) Cash from Operations (2017 - 2026)

Denali Therapeutics (DNLI) reported Cash from Operations of 131204000.0 for Q1 2026, little changed year-over-year from 130941058.15 in Q1 2025, and down 33.15% on a QoQ basis from 98538000.0 in Q4 2025.

Denali Therapeutics (DNLI) has 10 years of Cash from Operations data on file, last reported at 131204000.0 in Q1 2026.

  • Quarterly Cash from Operations changed 0.2% year-over-year to 131204000.0 in Q1 2026, while the trailing twelve-month figure through Mar 2026 was 412336000.0 (down 12.8% YoY) and the FY2025 annual result came in at 412600000.0, down 18.67% from the prior year.
  • Cash from Operations slipped to 131204000.0 in Q1 2026 per DNLI's latest filing, from 98538000.0 in the prior quarter.
  • Across five years, Cash from Operations topped out at 42898000.0 in Q2 2022 and bottomed at 131468000.0 in Q1 2025.
  • The 5-year median for Cash from Operations is 87363000.0 (2023), against an average of 87894411.76.
  • The widest annual swing landed in 2023, when Cash from Operations sank 163.81%; it then surged 32.31% in 2024.
  • Tracing DNLI's Cash from Operations over 5 years: stood at 72663000.0 in 2022, then tumbled by 35.77% to 98657000.0 in 2023, then rose by 15.15% to 83715000.0 in 2024, then retreated by 17.71% to 98538000.0 in 2025, then slumped by 33.15% to 131204000.0 in 2026.
  • Per Business Quant, the three latest DNLI Cash from Operations figures stand at 131204000.0 (Q1 2026), 98538000.0 (Q4 2025), and 107296000.0 (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Cash from Operations (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - -1.67 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - -
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -12.20 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - -2.49 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.43 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 1.08 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 70.50 Mn
10 Denali Therapeutics 3.82 Bn 3.82 Bn - -131.20 Mn

Historic Data

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DateValue
Mar 31, 2026 -131.20 Mn
Mar 31, 2026 -131.20 Mn
Dec 31, 2025 -98.54 Mn
Dec 31, 2025 -98.54 Mn
Sep 30, 2025 -107.30 Mn
Sep 30, 2025 -107.30 Mn
Jun 30, 2025 -75.30 Mn
Jun 30, 2025 -75.30 Mn
Mar 31, 2025 -131.47 Mn
Mar 31, 2025 -131.47 Mn
Dec 31, 2024 -83.72 Mn
Dec 31, 2024 -83.72 Mn
Sep 30, 2024 -59.14 Mn
Sep 30, 2024 -59.14 Mn
Jun 30, 2024 -91.22 Mn
Jun 30, 2024 -91.22 Mn
Mar 31, 2024 -113.62 Mn
Mar 31, 2024 -113.62 Mn
Dec 31, 2023 -98.66 Mn
Dec 31, 2023 -98.66 Mn
Sep 30, 2023 -87.36 Mn
Sep 30, 2023 -87.36 Mn
Jun 30, 2023 -113.17 Mn
Jun 30, 2023 -113.17 Mn
Mar 31, 2023 -58.80 Mn
Mar 31, 2023 -58.80 Mn
Dec 31, 2022 -72.66 Mn
Dec 31, 2022 -72.66 Mn
Sep 30, 2022 -57.05 Mn
Sep 30, 2022 -57.05 Mn
Jun 30, 2022 -42.90 Mn
Jun 30, 2022 -42.90 Mn
Mar 31, 2022 -72.11 Mn
Mar 31, 2022 -72.11 Mn
Dec 31, 2021 -65.49 Mn
Dec 31, 2021 -65.49 Mn
Sep 30, 2021 -41.43 Mn
Sep 30, 2021 -41.43 Mn
Jun 30, 2021 -54.22 Mn
Jun 30, 2021 -54.22 Mn
Mar 31, 2021 -50.24 Mn
Mar 31, 2021 -50.24 Mn
Dec 31, 2020 513.92 Mn
Dec 31, 2020 513.92 Mn
Sep 30, 2020 86,000.00
Sep 30, 2020 86,000.00
Jun 30, 2020 -43.36 Mn
Jun 30, 2020 -43.36 Mn
Mar 31, 2020 -54.49 Mn
Mar 31, 2020 -54.49 Mn
Sep 30, 2019 -103.93 Mn
Sep 30, 2019 -103.93 Mn
Jun 30, 2019 -43.18 Mn
Jun 30, 2019 -43.18 Mn
Mar 31, 2019 -30.32 Mn
Mar 31, 2019 -30.32 Mn
Dec 31, 2018 93.19 Mn
Dec 31, 2018 93.19 Mn
Sep 30, 2018 -34.82 Mn
Sep 30, 2018 -34.82 Mn
Jun 30, 2018 -41.82 Mn
Jun 30, 2018 -41.82 Mn
Mar 31, 2018 33.58 Mn
Mar 31, 2018 33.58 Mn
Dec 31, 2017 -18.34 Mn
Dec 31, 2017 -18.34 Mn
Sep 30, 2017 -21.92 Mn
Sep 30, 2017 -21.92 Mn
Jun 30, 2017 -17.57 Mn
Jun 30, 2017 -17.57 Mn
Mar 31, 2017 -18.81 Mn
Mar 31, 2017 -18.81 Mn