Growth Metrics

Calidi Biotherapeutics (CLDI) Operating Expenses (2022 - 2025)

Calidi Biotherapeutics' quarterly Operating Expenses came in at $4.5 million in Q4 2025, up 10.93% year-on-year from $4.0 million in Q4 2024, and down 11.53% quarter-over-quarter from $5.0 million in Q3 2025.

Calidi Biotherapeutics has reported Operating Expenses for 4 years, with the latest figure at $4.5 million in Q4 2025.

  • For the quarter ending Q4 2025, Operating Expenses rose 10.93% year-over-year to $4.5 million; the trailing twelve-month figure through Dec 2025 stood at $20.2 million (down 7.05% YoY), and the FY2025 full-year result was $20.2 million, down 7.05% from the prior year.
  • Operating Expenses for Q4 2025 stood at $4.5 million, down from $5.0 million in the prior quarter.
  • The five-year high for Operating Expenses was $9.8 million in Q4 2023, with the low at $361622.0 in Q2 2022.
  • Average Operating Expenses over 4 years is $5.2 million, with a median of $5.3 million recorded in 2023.
  • Year-over-year, Operating Expenses jumped 1707.69% in 2023 and plunged 59.0% in 2024.
  • Tracing CLDI's Operating Expenses over 4 years: stood at $4.7 million in 2022, then jumped by 109.47% to $9.8 million in 2023, then sank by 59.0% to $4.0 million in 2024, then advanced by 10.93% to $4.5 million in 2025.
  • The last three Operating Expenses figures came in at $4.5 million (Q4 2025), $5.0 million (Q3 2025), and $5.7 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Quantum Biopharma 1,638,563.89 Bn 1,638,563.89 Bn - 2.97 Mn
2 Alterity Therapeutics 767,934.24 Bn 767,934.20 Bn - 4.33 Mn
3 Legend Biotech 2,937.00 Bn 2,936.10 Bn 242.10 Mn -138.30 Mn
4 Nanobiotix 2,282.79 Bn 2,282.72 Bn - -
5 Akari Therapeutics 2,169.69 Bn 2,169.69 Bn - 15.76 Mn
6 Vertex Pharmaceuticals 110.41 Bn 103.16 Bn 2.59 Bn 1.85 Bn
7 Regeneron Pharmaceuticals 66.44 Bn 57.69 Bn 3.31 Bn 2.96 Bn
8 Evaxion A 65.44 Bn 65.42 Bn - -3.82 Mn
9 Alnylam Pharmaceuticals 39.53 Bn 36.52 Bn 959.66 Mn 898.54 Mn
10 Calidi Biotherapeutics - - - 4.47 Mn

Historic Data

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DateValue
Dec 31, 2025 4.47 Mn
Sep 30, 2025 5.05 Mn
Jun 30, 2025 5.66 Mn
Mar 31, 2025 5.06 Mn
Dec 31, 2024 4.03 Mn
Sep 30, 2024 5.23 Mn
Jun 30, 2024 5.77 Mn
Mar 31, 2024 6.75 Mn
Dec 31, 2023 9.82 Mn
Sep 30, 2023 7.22 Mn
Jun 30, 2023 6.54 Mn
Mar 31, 2023 5.41 Mn
Dec 31, 2022 4.69 Mn
Sep 30, 2022 6.99 Mn
Jun 30, 2022 361,622.00
Mar 31, 2022 528,858.00