Growth Metrics

BioNTech SE (BNTX) Operating Expenses (2018 - 2025)

BioNTech SE (BNTX) posted Operating Expenses of -$784.6 million for Q4 2025, up 2.17% on a QoQ basis from -$802.0 million in Q3 2025, and down 1.61% year-over-year from -$797.4 million in Q4 2024.

BioNTech SE (BNTX) has 8 years of Operating Expenses data on file, last reported at -$784.6 million in Q4 2025.

  • In Q4 2025, Operating Expenses fell 1.61% year-over-year to -$784.6 million; the TTM figure through Dec 2025 stood at -$3.0 billion (up 1.74% YoY), while the FY2025 annual figure was -$3.0 billion, up 0.57% from the prior year.
  • Operating Expenses grew to -$784.6 million in Q4 2025, from -$802.0 million in the prior quarter.
  • Across five years, Operating Expenses topped out at -$299.7 million in Q2 2021 and bottomed at -$813.6 million in Q2 2024.
  • A 5-year average of -$600.6 million and a median of -$653.9 million in 2022 frame the typical range for Operating Expenses.
  • Annual changes were most pronounced in 2021 — Operating Expenses slumped 131816999.25% — and 2025, when it grew 12.79%.
  • Year by year, Operating Expenses stood at -$460.3 million in 2021, then sank by 39.56% to -$642.4 million in 2022, then retreated by 17.58% to -$755.4 million in 2023, then declined by 2.22% to -$772.2 million in 2024, then slipped by 1.61% to -$784.6 million in 2025.
  • The last three Operating Expenses figures came in at -$784.6 million (Q4 2025), -$802.0 million (Q3 2025), and -$709.5 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Quantum Biopharma 961,148.99 Bn 961,148.98 Bn - 2.97 Mn
2 Alterity Therapeutics 744,933.29 Bn 744,933.26 Bn - 4.33 Mn
3 Legend Biotech 2,540.00 Bn 2,539.71 Bn 242.10 Mn -138.30 Mn
4 Nanobiotix 2,199.85 Bn 2,199.78 Bn - -
5 Akari Therapeutics 1,635.88 Bn 1,635.88 Bn - 15.76 Mn
6 Vertex Pharmaceuticals 111.32 Bn 104.07 Bn 2.59 Bn 1.85 Bn
7 Evaxion A 62.56 Bn 62.54 Bn - -3.82 Mn
8 Regeneron Pharmaceuticals 62.55 Bn 53.79 Bn 3.31 Bn 2.96 Bn
9 Alnylam Pharmaceuticals 39.57 Bn 36.56 Bn 959.66 Mn 898.54 Mn
10 BioNTech SE 27.66 Bn 7.53 Bn 668.28 Mn -784.57 Mn

Historic Data

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DateValue
Dec 31, 2025 -784.57 Mn
Sep 30, 2025 -801.97 Mn
Jun 30, 2025 -709.51 Mn
Mar 31, 2025 -665.32 Mn
Dec 31, 2024 -772.17 Mn
Sep 30, 2024 -749.75 Mn
Jun 30, 2024 -813.59 Mn
Mar 31, 2024 -678.43 Mn
Dec 31, 2023 -755.42 Mn
Sep 30, 2023 -693.43 Mn
Jun 30, 2023 -537.06 Mn
Mar 31, 2023 -478.50 Mn
Dec 31, 2022 -642.45 Mn
Sep 30, 2022 -486.79 Mn
Jun 30, 2022 -565.11 Mn
Mar 31, 2022 -422.67 Mn
Dec 31, 2021 -460.33 Mn
Sep 30, 2021 -387.51 Mn
Jun 30, 2021 -299.74 Mn
Mar 31, 2021 -307.71 Mn
Dec 31, 2020 -349.22
Mar 31, 2020 -10.16 Mn
Dec 31, 2019 517.49 Mn
Sep 30, 2019 -67.85 Mn
Dec 31, 2018 122.47 Mn
Sep 30, 2018 -45.77 Mn