BioNTech SE (BNTX) Operating Expenses (2018 - 2025)
BioNTech SE (BNTX) posted Operating Expenses of -$784.6 million for Q4 2025, up 2.17% on a QoQ basis from -$802.0 million in Q3 2025, and down 1.61% year-over-year from -$797.4 million in Q4 2024.
BioNTech SE (BNTX) has 8 years of Operating Expenses data on file, last reported at -$784.6 million in Q4 2025.
- In Q4 2025, Operating Expenses fell 1.61% year-over-year to -$784.6 million; the TTM figure through Dec 2025 stood at -$3.0 billion (up 1.74% YoY), while the FY2025 annual figure was -$3.0 billion, up 0.57% from the prior year.
- Operating Expenses grew to -$784.6 million in Q4 2025, from -$802.0 million in the prior quarter.
- Across five years, Operating Expenses topped out at -$299.7 million in Q2 2021 and bottomed at -$813.6 million in Q2 2024.
- A 5-year average of -$600.6 million and a median of -$653.9 million in 2022 frame the typical range for Operating Expenses.
- Annual changes were most pronounced in 2021 — Operating Expenses slumped 131816999.25% — and 2025, when it grew 12.79%.
- Year by year, Operating Expenses stood at -$460.3 million in 2021, then sank by 39.56% to -$642.4 million in 2022, then retreated by 17.58% to -$755.4 million in 2023, then declined by 2.22% to -$772.2 million in 2024, then slipped by 1.61% to -$784.6 million in 2025.
- The last three Operating Expenses figures came in at -$784.6 million (Q4 2025), -$802.0 million (Q3 2025), and -$709.5 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | Opex (Qtr) |
|---|---|---|---|---|---|
| 1 | Quantum Biopharma | 961,148.99 Bn | 961,148.98 Bn | - | 2.97 Mn |
| 2 | Alterity Therapeutics | 744,933.29 Bn | 744,933.26 Bn | - | 4.33 Mn |
| 3 | Legend Biotech | 2,540.00 Bn | 2,539.71 Bn | 242.10 Mn | -138.30 Mn |
| 4 | Nanobiotix | 2,199.85 Bn | 2,199.78 Bn | - | - |
| 5 | Akari Therapeutics | 1,635.88 Bn | 1,635.88 Bn | - | 15.76 Mn |
| 6 | Vertex Pharmaceuticals | 111.32 Bn | 104.07 Bn | 2.59 Bn | 1.85 Bn |
| 7 | Evaxion A | 62.56 Bn | 62.54 Bn | - | -3.82 Mn |
| 8 | Regeneron Pharmaceuticals | 62.55 Bn | 53.79 Bn | 3.31 Bn | 2.96 Bn |
| 9 | Alnylam Pharmaceuticals | 39.57 Bn | 36.56 Bn | 959.66 Mn | 898.54 Mn |
| 10 | BioNTech SE | 27.66 Bn | 7.53 Bn | 668.28 Mn | -784.57 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -784.57 Mn |
| Sep 30, 2025 | -801.97 Mn |
| Jun 30, 2025 | -709.51 Mn |
| Mar 31, 2025 | -665.32 Mn |
| Dec 31, 2024 | -772.17 Mn |
| Sep 30, 2024 | -749.75 Mn |
| Jun 30, 2024 | -813.59 Mn |
| Mar 31, 2024 | -678.43 Mn |
| Dec 31, 2023 | -755.42 Mn |
| Sep 30, 2023 | -693.43 Mn |
| Jun 30, 2023 | -537.06 Mn |
| Mar 31, 2023 | -478.50 Mn |
| Dec 31, 2022 | -642.45 Mn |
| Sep 30, 2022 | -486.79 Mn |
| Jun 30, 2022 | -565.11 Mn |
| Mar 31, 2022 | -422.67 Mn |
| Dec 31, 2021 | -460.33 Mn |
| Sep 30, 2021 | -387.51 Mn |
| Jun 30, 2021 | -299.74 Mn |
| Mar 31, 2021 | -307.71 Mn |
| Dec 31, 2020 | -349.22 |
| Mar 31, 2020 | -10.16 Mn |
| Dec 31, 2019 | 517.49 Mn |
| Sep 30, 2019 | -67.85 Mn |
| Dec 31, 2018 | 122.47 Mn |
| Sep 30, 2018 | -45.77 Mn |