BioNTech SE (BNTX) Operating Expenses (2018 - 2025)

BioNTech SE's (BNTX) quarterly Operating Expenses came in at -$784.6 million in Q4 2025, down 1.61% year-on-year from -$797.4 million in Q4 2024, and up 2.17% quarter-over-quarter from -$802.0 million in Q3 2025.

BioNTech SE (BNTX) Operating Expenses (2018 - 2025) Analysis & Trends

BioNTech SE has disclosed Operating Expenses across 8 years of filings, most recently posting -$784.6 million for Q4 2025.

  • Operating Expenses for Q4 2025 came in at -$784.6 million, down 1.61% year-over-year; the trailing twelve-month figure through Dec 2025 was -$3.0 billion (up 1.74% YoY), and the FY2025 annual result was -$3.0 billion, up 0.57% from the prior year.
  • Operating Expenses came in at -$784.6 million for Q4 2025 at BioNTech SE, up from -$802.0 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of -$299.7 million in Q2 2021 to a low of -$813.6 million in Q2 2024.
  • The 5-year median for Operating Expenses is -$653.9 million (2022), against an average of -$600.6 million.
  • Across the five-year window, Operating Expenses slumped 1511.72% in 2021 and climbed 12.79% in 2025, its largest moves.
  • BioNTech SE's Operating Expenses stood at -$460.3 million in 2021, then slumped by 39.56% to -$642.4 million in 2022, then dropped by 17.58% to -$755.4 million in 2023, then decreased by 2.22% to -$772.2 million in 2024, then fell by 1.61% to -$784.6 million in 2025.
  • The last three Operating Expenses figures came in at -$784.6 million (Q4 2025), -$802.0 million (Q3 2025), and -$709.5 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 925,601.88 Bn 925,601.85 Bn - 4.33 Mn
2 Belite Bio 58,560.00 Bn 58,560.00 Bn - 32.68 Mn
3 Quantum Biopharma 17,284.41 Bn 17,284.40 Bn - 2.97 Mn
4 Legend Biotech 2,809.00 Bn 2,808.71 Bn 242.10 Mn -138.30 Mn
5 Evaxion A 1,334.43 Bn 1,334.42 Bn - -3.82 Mn
6 Akari Therapeutics 1,312.27 Bn 1,312.26 Bn - 15.76 Mn
7 Psyence Biomedical 212.16 Bn 212.16 Bn - 574,669.00
8 Vertex Pharmaceuticals 114.83 Bn 107.58 Bn 2.59 Bn 1.85 Bn
9 Abivax 91.96 Bn 91.96 Bn - -67.40 Mn
10 BioNTech SE 27.38 Bn 10.07 Bn 668.28 Mn -784.57 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -784.57 Mn
Sep 30, 2025 -801.97 Mn
Jun 30, 2025 -709.51 Mn
Mar 31, 2025 -665.32 Mn
Dec 31, 2024 -772.17 Mn
Sep 30, 2024 -749.75 Mn
Jun 30, 2024 -813.59 Mn
Mar 31, 2024 -678.43 Mn
Dec 31, 2023 -755.42 Mn
Sep 30, 2023 -693.43 Mn
Jun 30, 2023 -537.06 Mn
Mar 31, 2023 -478.50 Mn
Dec 31, 2022 -642.45 Mn
Sep 30, 2022 -486.79 Mn
Jun 30, 2022 -565.11 Mn
Mar 31, 2022 -422.67 Mn
Dec 31, 2021 -460.33 Mn
Sep 30, 2021 -387.51 Mn
Jun 30, 2021 -299.74 Mn
Mar 31, 2021 -307.71 Mn