As of September 29, 2026, the three largest insider holders of LXRX are Participations S.A R.L. Artal (Director, 175.16Mn shares), International S.C.A. Artal (Director, 136.18Mn shares), Us Partners Llc Invus (Director, 5.45Mn shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Participations S.A R.L. Artal | Director, TenPercentOwner | 0 | 175,564,497 | 175,564,497 | 53.6% | 08 May, 2026 |
| 2 | International S.C.A. Artal | Director, TenPercentOwner | 0 | 137,331,403 | 137,331,403 | 41.9% | 14 May, 2024 |
| 3 | Us Partners Llc Invus | Director, TenPercentOwner | 0 | 5,451,204 | 5,451,204 | 1.7% | 09 Aug, 2022 |
| 4 | Raymond Debbane | Director | 1,995,498 | 0 | 1,995,498 | 0.6% | 04 Jun, 2026 |
| 5 | Global Management, Llc Invus | Director, TenPercentOwner | 0 | 1,905,607 | 1,905,607 | 0.6% | 04 Feb, 2026 |
| 6 | Lonnel Coats | Chief Executive Officer | 1,098,068 | 0 | 1,098,068 | 0.3% | 29 Feb, 2024 |
| 7 | Brian T Crum | Svp, General Counsel Secr. | 428,802 | 0 | 428,802 | 0.1% | 03 Mar, 2026 |
| 8 | Philippe Amouyal | Director | 374,486 | 0 | 374,486 | 0.1% | 04 Jun, 2026 |
| 9 | Alan J Main | Evp, Innov Chem Sciences | 339,104 | 0 | 339,104 | 0.1% | 03 Mar, 2025 |
| 10 | Jeffrey L Wade | President And Cfo | 324,214 | 0 | 324,214 | 0.1% | 29 Feb, 2024 |
| 11 | Craig B Granowitz | Svp, Chief Medical Officer | 323,430 | 0 | 323,430 | 0.1% | 03 Mar, 2026 |
| 12 | Michael Exton | Chief Executive Officer | 298,432 | 0 | 298,432 | 0.1% | 03 Mar, 2026 |
| 13 | Christopher J Sobecki | Director | 293,177 | 0 | 293,177 | 0.1% | 04 Jun, 2026 |
| 14 | Wendy Mcdermott | Svp, Human Resources | 277,945 | 0 | 277,945 | 0.1% | 03 Mar, 2026 |
| 15 | Sam L Barker | Director | 213,771 | 0 | 213,771 | 0.1% | 04 Jun, 2026 |
| 16 | Judith L Swain | Director | 174,486 | 0 | 174,486 | 0.1% | 04 Jun, 2026 |
| 17 | Kenneth B. Kassler-Taub | Svp, Regulatory Qa | 162,672 | 0 | 162,672 | 0.0% | 29 Feb, 2024 |
| 18 | Suma Gopinathan | Svp, Discovery | 150,132 | 0 | 150,132 | 0.0% | 03 Mar, 2026 |
| 19 | Diane E. Sullivan | Director | 126,122 | 0 | 126,122 | 0.0% | 04 Jun, 2026 |
| 20 | Scott M Coiante | Svp, Chief Financial Officer | 105,356 | 0 | 105,356 | 0.0% | 03 Mar, 2026 |
| 21 | Lisa Defrancesco | Svp, Ir And Corp Comm | 93,869 | 0 | 93,869 | 0.0% | 03 Mar, 2026 |
| 22 | Ivan Cheung | Director | 89,312 | 0 | 89,312 | 0.0% | 04 Jun, 2026 |
| 23 | Kristen Alexander | Vp, Finance And Accounting | 76,368 | 0 | 76,368 | 0.0% | 03 Mar, 2025 |
| 24 | Kiernan Seth | Vp, Chief Commercial Officer | 53,136 | 0 | 53,136 | 0.0% | 01 Mar, 2023 |
| 25 | Robert J Md Lefkowitz | Director | 48,364 | 0 | 48,364 | 0.0% | 29 Apr, 2024 |
| 26 | Alan S Nies | Director | 41,046 | 0 | 41,046 | 0.0% | 22 May, 2023 |
| 27 | Frank Palantoni | Director | 40,332 | 0 | 40,332 | 0.0% | 22 May, 2023 |
| 28 | Rachel Yap Martens | Svp, Partnerships Corp Strat | 31,264 | 0 | 31,264 | 0.0% | 03 Mar, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 03 Jun, 2026 | Philippe Amouyal | Director | Acquired M | 89,312 | $0.00 | $0 | 374,486 | Direct |
| 03 Jun, 2026 | Raymond Debbane | Director | Acquired M | 89,312 | $0.00 | $0 | 1,995,498 | Direct |
| 03 Jun, 2026 | Ivan Cheung | Director | Acquired M | 89,312 | $0.00 | $0 | 89,312 | Direct |
| 03 Jun, 2026 | Judith L Swain | Director | Acquired M | 89,312 | $0.00 | $0 | 174,486 | Direct |
| 03 Jun, 2026 | Diane E. Sullivan | Director | Acquired M | 89,312 | $0.00 | $0 | 126,122 | Direct |
| 03 Jun, 2026 | Sam L Barker | Director | Acquired M | 89,312 | $0.00 | $0 | 213,771 | Direct |
| 03 Jun, 2026 | Christopher J Sobecki | Director | Acquired M | 89,312 | $0.00 | $0 | 293,177 | Direct |
| 03 Jun, 2026 | Judith L Swain | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Ivan Cheung | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Diane E. Sullivan | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Sam L Barker | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Christopher J Sobecki | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Philippe Amouyal | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Raymond Debbane | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 30 Apr, 2026 | Participations S.A R.L. Artal | Director, TenPercentOwner | Acquired M | 20,421,735 | $0.00 | $0 | 175,156,062 | Indirect |
| 30 Apr, 2026 | Participations S.A R.L. Artal | Director, TenPercentOwner | Acquired A | 408,435 | — | — | 408,435 | Indirect |
| 30 Apr, 2026 | Participations S.A R.L. Artal | Director, TenPercentOwner | Disposed M | 408,435 | $0.00 | $0 | 0 | Indirect |
| 01 May, 2026 | Ivan Cheung | Director | Acquired A | 35,714 | $0.00 | $0 | 35,714 | Direct |
| 01 May, 2026 | Raymond Debbane | Director | Acquired A | 35,714 | $0.00 | $0 | 35,714 | Direct |
| 01 May, 2026 | Diane E. Sullivan | Director | Acquired A | 35,714 | $0.00 | $0 | 35,714 | Direct |