As of August 29, 2026, the three largest insider holders of LXRX are Participations S.A R.L. Artal (Director, 175.16Mn shares), International S.C.A. Artal (Director, 136.18Mn shares), International S.C.A. Artal (Director, 136.18Mn shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Participations S.A R.L. Artal | Director, TenPercentOwner | 0 | 175,564,497 | 175,564,497 | 53.6% | 08 May, 2026 |
| 2 | International S.C.A. Artal | Director, TenPercentOwner | 0 | 137,331,403 | 137,331,403 | 41.9% | 14 May, 2024 |
| 3 | Us Partners Llc Invus | Director, TenPercentOwner | 0 | 5,451,204 | 5,451,204 | 1.7% | 09 Aug, 2022 |
| 4 | Raymond Debbane | Director | 1,995,498 | 0 | 1,995,498 | 0.6% | 04 Jun, 2026 |
| 5 | Global Management, Llc Invus | Director, TenPercentOwner | 0 | 1,905,607 | 1,905,607 | 0.6% | 04 Feb, 2026 |
| 6 | Lonnel Coats | Chief Executive Officer | 1,098,068 | 0 | 1,098,068 | 0.3% | 29 Feb, 2024 |
| 7 | Brian T Crum | Svp, General Counsel Secr. | 428,802 | 0 | 428,802 | 0.1% | 03 Mar, 2026 |
| 8 | Philippe Amouyal | Director | 374,486 | 0 | 374,486 | 0.1% | 04 Jun, 2026 |
| 9 | Alan J Main | Evp, Innov Chem Sciences | 339,104 | 0 | 339,104 | 0.1% | 03 Mar, 2025 |
| 10 | Jeffrey L Wade | President And Cfo | 324,214 | 0 | 324,214 | 0.1% | 29 Feb, 2024 |
| 11 | Craig B Granowitz | Svp, Chief Medical Officer | 323,430 | 0 | 323,430 | 0.1% | 03 Mar, 2026 |
| 12 | Michael Exton | Chief Executive Officer | 298,432 | 0 | 298,432 | 0.1% | 03 Mar, 2026 |
| 13 | Christopher J Sobecki | Director | 293,177 | 0 | 293,177 | 0.1% | 04 Jun, 2026 |
| 14 | Wendy Mcdermott | Svp, Human Resources | 277,945 | 0 | 277,945 | 0.1% | 03 Mar, 2026 |
| 15 | Sam L Barker | Director | 213,771 | 0 | 213,771 | 0.1% | 04 Jun, 2026 |
| 16 | Judith L Swain | Director | 174,486 | 0 | 174,486 | 0.1% | 04 Jun, 2026 |
| 17 | Kenneth B. Kassler-Taub | Svp, Regulatory Qa | 162,672 | 0 | 162,672 | 0.0% | 29 Feb, 2024 |
| 18 | Suma Gopinathan | Svp, Discovery | 150,132 | 0 | 150,132 | 0.0% | 03 Mar, 2026 |
| 19 | Diane E. Sullivan | Director | 126,122 | 0 | 126,122 | 0.0% | 04 Jun, 2026 |
| 20 | Scott M Coiante | Svp, Chief Financial Officer | 105,356 | 0 | 105,356 | 0.0% | 03 Mar, 2026 |
| 21 | Lisa Defrancesco | Svp, Ir And Corp Comm | 93,869 | 0 | 93,869 | 0.0% | 03 Mar, 2026 |
| 22 | Ivan Cheung | Director | 89,312 | 0 | 89,312 | 0.0% | 04 Jun, 2026 |
| 23 | Kristen Alexander | Vp, Finance And Accounting | 76,368 | 0 | 76,368 | 0.0% | 03 Mar, 2025 |
| 24 | Kiernan Seth | Vp, Chief Commercial Officer | 53,136 | 0 | 53,136 | 0.0% | 01 Mar, 2023 |
| 25 | Robert J Md Lefkowitz | Director | 48,364 | 0 | 48,364 | 0.0% | 29 Apr, 2024 |
| 26 | Alan S Nies | Director | 41,046 | 0 | 41,046 | 0.0% | 22 May, 2023 |
| 27 | Rachel Yap Martens | Svp, Partnerships Corp Strat | 31,264 | 0 | 31,264 | 0.0% | 03 Mar, 2026 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 03 Jun, 2026 | Philippe Amouyal | Director | Acquired M | 89,312 | $0.00 | $0 | 374,486 | Direct |
| 03 Jun, 2026 | Christopher J Sobecki | Director | Acquired M | 89,312 | $0.00 | $0 | 293,177 | Direct |
| 03 Jun, 2026 | Ivan Cheung | Director | Acquired M | 89,312 | $0.00 | $0 | 89,312 | Direct |
| 03 Jun, 2026 | Sam L Barker | Director | Acquired M | 89,312 | $0.00 | $0 | 213,771 | Direct |
| 03 Jun, 2026 | Raymond Debbane | Director | Acquired M | 89,312 | $0.00 | $0 | 1,995,498 | Direct |
| 03 Jun, 2026 | Judith L Swain | Director | Acquired M | 89,312 | $0.00 | $0 | 174,486 | Direct |
| 03 Jun, 2026 | Diane E. Sullivan | Director | Acquired M | 89,312 | $0.00 | $0 | 126,122 | Direct |
| 03 Jun, 2026 | Ivan Cheung | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Christopher J Sobecki | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Philippe Amouyal | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Sam L Barker | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Judith L Swain | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Diane E. Sullivan | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 03 Jun, 2026 | Raymond Debbane | Director | Disposed M | 89,312 | $0.00 | $0 | 0 | Direct |
| 30 Apr, 2026 | Participations S.A R.L. Artal | Director, TenPercentOwner | Acquired M | 20,421,735 | $0.00 | $0 | 175,156,062 | Indirect |
| 30 Apr, 2026 | Participations S.A R.L. Artal | Director, TenPercentOwner | Acquired A | 408,435 | — | — | 408,435 | Indirect |
| 30 Apr, 2026 | Participations S.A R.L. Artal | Director, TenPercentOwner | Disposed M | 408,435 | $0.00 | $0 | 0 | Indirect |
| 01 May, 2026 | Philippe Amouyal | Director | Acquired A | 35,714 | $0.00 | $0 | 35,714 | Direct |
| 01 May, 2026 | Christopher J Sobecki | Director | Acquired A | 35,714 | $0.00 | $0 | 35,714 | Direct |
| 01 May, 2026 | Diane E. Sullivan | Director | Acquired A | 35,714 | $0.00 | $0 | 35,714 | Direct |